Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation

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Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.544718
P932PMC publication ID4007449
P698PubMed publication ID24648522

P2093author name stringYing Chen
Jian Du
Yuxian Shen
Min Li
Li Cheng
Li Yu
Qingli Luo
Ran An
Jilong Shen
Deyong Chu
He Chen
Xiucai Xu
Lijuan Wan
Lijian Chen
Yujun Shen
Aimei Zhang
Zhongru Jiang
P2860cites workThe mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stabilityQ24317171
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligaseQ24337774
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Q27341809
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
ToxoplasmosisQ30080013
Toxoplasma gondii infection in Kyrgyzstan: seroprevalence, risk factor analysis, and estimate of congenital and AIDS-related toxoplasmosisQ30427210
Characterization of protein kinase A-mediated phosphorylation of ezrin in gastric parietal cell activationQ31148511
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondiiQ33274196
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.Q33591077
NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.Q33814730
Alternative versus classical activation of macrophages.Q33868142
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth controlQ34023014
Modulation of innate immunity by Toxoplasma gondii virulence effectorsQ34033981
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.Q34121309
Interactions between the ROP18 kinase and host cell proteins that aid in the parasitism of Toxoplasma gondiiQ34172319
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.Q34501481
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondiiQ34591236
Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal eliminationQ34959023
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.Q35090382
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Q35102296
COMMD proteins and the control of the NF kappa B pathwayQ36760008
Polymorphic secreted kinases are key virulence factors in toxoplasmosisQ37105671
Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activationQ37117107
Toxoplasma gondii inhibits apoptosis in infected cells by caspase inactivation and NF-kappaB activationQ37205977
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathwayQ37723806
14-3-3zeta cooperates with phosphorylated Plk1 and is required for correct cytokinesisQ37971772
NF-κB: where did it come from and why?Q37995678
NF-κB and the link between inflammation and cancerQ37995696
Advances in understanding immunity to Toxoplasma gondiiQ39980910
Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B.Q40787838
Macrophages as a battleground for toxoplasma pathogenesisQ42766938
Inhibition of caspase activation and a requirement for NF-kappaB function in the Toxoplasma gondii-mediated blockade of host apoptosisQ42796145
Activation of NF-kappaB by Toxoplasma gondii correlates with increased expression of antiapoptotic genes and localization of phosphorylated IkappaB to the parasitophorous vacuole membraneQ42796162
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotypeQ47991756
Congenital toxoplasmosis: continued parasite proliferation in the fetal brain despite maternal immunological control in other tissuesQ48332630
Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance.Q51024816
Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii.Q54201258
Suppression of NF‐κB Activation by Infection withToxoplasma gondiiQ64140406
Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkappaBalphaQ81338152
Host and parasite-derived IKK activities direct distinct temporal phases of NF-kappaB activation and target gene expression following Toxoplasma gondii infectionQ81598989
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
Toxoplasma gondiiQ131003
P1104number of pages15
P304page(s)12578-12592
P577publication date2014-03-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleToxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation
P478volume289

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cites work (P2860)
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Q49829407Genome-Wide Bimolecular Fluorescence Complementation-Based Proteomic Analysis of Toxoplasma gondii ROP18's Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis
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Q40934842Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection
Q90053650iTRAQ-Based Global Phosphoproteomics Reveals Novel Molecular Differences Between Toxoplasma gondii Strains of Different Genotypes

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