Synthetic biology approaches in drug discovery and pharmaceutical biotechnology

scientific article

Synthetic biology approaches in drug discovery and pharmaceutical biotechnology is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1003142349
P356DOI10.1007/S00253-010-2578-3
P932PMC publication ID2872025
P698PubMed publication ID20396881
P5875ResearchGate publication ID43161372

P50authorHeinz NeumannQ56843267
P2093author name stringPetra Neumann-Staubitz
P2860cites workFunctional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein alpha-subunit chimerasQ73323750
Creating bacterial strains from genomes that have been cloned and engineered in yeastQ84441441
Production of the antimalarial drug precursor artemisinic acid in engineered yeastQ22061873
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genomeQ22066288
Combination bacteriolytic therapy for the treatment of experimental tumorsQ24555050
Expression in Escherichia coli of chemically synthesized genes for human insulinQ24599184
Structural basis for the promiscuous biosynthetic prenylation of aromatic natural productsQ24608866
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Environmental signal integration by a modular AND gateQ24670375
Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseQ27648476
Kemp elimination catalysts by computational enzyme designQ27650119
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
Catalytic promiscuity and the evolution of new enzymatic activitiesQ28140063
An expanded eukaryotic genetic codeQ28201981
Engineering a mevalonate pathway in Escherichia coli for production of terpenoidsQ28207854
Expanding the genetic code of Escherichia coliQ28213675
Enzymatic assembly of DNA molecules up to several hundred kilobasesQ28241142
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulinQ28247685
Programming cells by multiplex genome engineering and accelerated evolutionQ28253066
Substrate and functional diversity of lysine acetylation revealed by a proteomics surveyQ28258445
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genomeQ28265807
Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosomeQ28273162
Synthetic biology: engineering Escherichia coli to see lightQ28283472
Environmentally controlled invasion of cancer cells by engineered bacteriaQ28285227
Protein-based organelles in bacteria: carboxysomes and related microcompartmentsQ28289715
Mono- and sesquiterpenes and antifungal constituents from Artemisia speciesQ28371893
Total Synthesis of Anticancer Agent Taxol Achieved by Two Different RoutesQ29027286
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.Q45952293
Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry.Q45974834
Microbial sensors for small molecules: development of a mevalonate biosensorQ46076042
Engineering Escherichia coli for production of functionalized terpenoids using plant P450sQ46094196
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).Q46094956
High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coliQ46213323
Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerizationQ46437752
Recombinant expression of selectively sulfated proteins in Escherichia coliQ46578070
Heterologous production of epothilone C and D in Escherichia coli.Q46609321
Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiaeQ46701927
Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.Q46751659
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.Q46832912
Genetic incorporation of unnatural amino acids into proteins in mammalian cellsQ46866635
Programmed population control by cell-cell communication and regulated killing.Q51693435
Controlling gene expression in living cells through small molecule-RNA interactions.Q54122320
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion.Q54439095
Functional aptamers and aptazymes in biotechnology, diagnostics, and therapyQ36917651
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coliQ37080670
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coliQ37081542
De novo biosynthetic pathways: rational design of microbial chemical factoriesQ37251461
Engineering the Salmonella type III secretion system to export spider silk monomersQ37379494
Revisiting the modularity of modular polyketide synthasesQ37393154
De novo design of catalytic proteinsQ37415513
Green light to illuminate signal transduction events.Q37439970
Computational design tools for synthetic biologyQ37598457
Emerging applications of riboswitches in chemical biologyQ37668585
Engineering signal transduction pathwaysQ37677850
Use of two-component signal transduction systems in the construction of synthetic genetic networksQ37690978
Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway.Q38289907
Tetracycline-aptamer-mediated translational regulation in yeastQ38350910
Conditional gene expression by controlling translation with tetracycline-binding aptamersQ38356395
Genetically engineered Salmonella typhimurium as an imageable therapeutic probe for cancerQ39760012
Next-generation synthetic gene networksQ39919274
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylationQ40097842
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxolQ40686859
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivoQ40773171
Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol).Q41056495
Clinical overview of the taxanes.Q41606989
Improving lycopene production in Escherichia coli by engineering metabolic controlQ41734961
Synthetic biology: promises and challengesQ42919282
Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.Q43273104
Production of ansamycin polyketide precursors in Escherichia coliQ43718451
A simple conversion of artemisinic acid into artemisininQ43863386
In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensorsQ44370241
Analysis of underivatized amino acids and their D/L-enantiomers by sheathless capillary electrophoresis/electrospray ionization mass spectrometryQ44377902
Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interactionQ44447645
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.Q44552141
Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patientsQ44591603
A chemical toolkit for proteins--an expanded genetic codeQ44801045
Site-specific PEGylation of proteins containing unnatural amino acidsQ45121216
Functional expression of olfactory receptors in yeast and development of a bioassay for odorant screeningQ45227547
Radio-responsive recA promoter significantly increases TNFalpha production in recombinant clostridia after 2 Gy irradiationQ45879277
Computational design of receptor and sensor proteins with novel functionsQ30332826
Production of cyclic peptides and proteins in vivoQ30816360
Identification of allosteric peptide agonists of CXCR4.Q30868390
Taxol biosynthetic genesQ31004828
A systematic method for identifying small-molecule modulators of protein-protein interactionsQ31122646
A method for the generation of glycoprotein mimeticsQ31131271
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coliQ32075037
Tuning genetic control through promoter engineeringQ33222305
Synthetic promoter libraries--tuning of gene expressionQ33231382
Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage displayQ33279697
Combinatorial biosynthesis for drug developmentQ33286975
Discovery of antibacterial cyclic peptides that inhibit the ClpXP proteaseQ33289276
Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokinesQ33591159
Macromolecular compartmentation and channeling.Q33769793
Designed divergent evolution of enzyme functionQ33993746
Visualization of maltose uptake in living yeast cells by fluorescent nanosensors.Q34075946
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.Q34101057
Engineered biosynthesis of aklanonic acid analoguesQ34293749
Programmable cells: interfacing natural and engineered gene networksQ34322635
Taxol: biosynthesis, molecular genetics, and biotechnological applicationsQ34427992
Genome transplantation in bacteria: changing one species to anotherQ34643428
The chemistry of taxol and related taxoidsQ34753279
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) productionQ34779126
Synthetic protein scaffolds provide modular control over metabolic flux.Q34995237
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Q35131209
Bacteria as tumour-targeting vectorsQ35215803
The use of live attenuated bacteria as a delivery system for heterologous antigensQ35809240
Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.Q35813522
Periplasmic binding proteins: a versatile superfamily for protein engineeringQ35863927
Prenylated flavonoids: pharmacology and biotechnologyQ36079822
Round and round we go: cyclic peptides in diseaseQ36569984
Genetic parts to program bacteriaQ36595370
Construction of a fluorescent biosensor familyQ36639569
Application of functional genomics to pathway optimization for increased isoprenoid production.Q36672684
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbiotechnologyQ7108
synthetic biologyQ862838
drug discoveryQ1418791
bacteriaQ10876
biomedical investigative techniqueQ66648976
P304page(s)75-86
P577publication date2010-04-16
2010-06-01
P1433published inApplied Microbiology and BiotechnologyQ13553694
P1476titleSynthetic biology approaches in drug discovery and pharmaceutical biotechnology
P478volume87

Reverse relations

cites work (P2860)
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Q38994624Challenges for the European governance of synthetic biology for human health
Q99731145Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection
Q46714174Databases of the thiotemplate modular systems (CSDB) and their in silico recombinants (r-CSDB).
Q34215866Directed evolution as a powerful synthetic biology tool
Q28080553Emerging concepts promising new horizons for marine biodiscovery and synthetic biology
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Q34258777Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor
Q34459997mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands

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