Human Herpesvirus 6A Exhibits Restrictive Propagation with Limited Activation of the Protein Kinase R-eIF2α Stress Pathway

scientific article

Human Herpesvirus 6A Exhibits Restrictive Propagation with Limited Activation of the Protein Kinase R-eIF2α Stress Pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.02120-16
P932PMC publication ID5391470
P698PubMed publication ID28202752

P2093author name stringNiza Frenkel
Eyal Sharon
P2860cites workVirologic and immunologic evidence supporting an association between HHV-6 and Hashimoto's thyroiditisQ21131390
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 proteinQ22010192
Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinaseQ24290751
The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domainQ24292276
Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 proteinQ24538727
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alphaQ24548092
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivoQ24563365
Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complexQ24675640
Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: reviewQ26823683
Clinical impact of primary infection with roseolovirusesQ27025365
Human cytomegalovirus infection activates and regulates the unfolded protein responseQ27469611
Interferon-inducible antiviral effectorsQ27486790
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylationQ28216131
Human herpesvirus-6 infection in children. A prospective study of complications and reactivationQ28245288
Peculiarities of herpes simplex virus (HSV) transcription: an overviewQ28273151
Isolation of a new virus, HBLV, in patients with lymphoproliferative disordersQ28282589
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasisQ28510028
Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent mannerQ28580378
Gene-specific regulation by general translation factorsQ28611181
HHV-6 reactivation and associated sequelae after hematopoietic cell transplantationQ28727925
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Coping with stress: eIF2 kinases and translational controlQ29619787
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's diseaseQ31041277
Use of amplicon-6 vectors derived from human herpesvirus 6 for efficient expression of membrane-associated and -secreted proteins in T cellsQ33201424
In vitro evaluation of antiviral and virucidal activity of a high molecular weight hyaluronic acidQ39570438
Identification of a lytic-cycle Epstein-Barr virus gene product that can regulate PKR activationQ39698299
Microarray-based determination of the lytic cascade of human herpesvirus 6B.Q39822084
Antiviral effect of arginine against herpes simplex virus type 1.Q39872490
Essential role for either TRS1 or IRS1 in human cytomegalovirus replicationQ39884830
Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and IrelandQ40507964
Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipientsQ40578590
Expression of initiation factor genes in mammalian cellsQ40606850
Efficient propagation of human herpesvirus 6B in a T-cell line derived from a patient with adult T-cell leukemia/lymphomaQ40801326
Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation.Q40849677
HHV-6 infection after allogeneic hematopoietic stem cell transplantation: From chromosomal integration to viral co-infections and T-cell reconstitution patterns.Q40930088
Difference in permissiveness of human fibroblast cells to variants A and B of human herpesvirus-6.Q41187205
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinaseQ41602853
Double-stranded RNA binding by human cytomegalovirus pTRS1.Q42147481
Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection.Q42184608
Selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases.Q42273792
Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 proteinQ42579466
Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infectionQ42589554
Reactivation of Herpesvirus Type 6 in Children Receiving Bone Marrow Transplants for LeukemiaQ43980574
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiationQ46772123
Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal CellsQ58666282
Identification of human herpesvirus-6 as a causal agent for exanthem subitumQ69917877
HHV-6 and multiple sclerosisQ74539580
Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6Q33339643
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
Eukaryotic initiation factor eIF2.Q33601625
Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domainQ33781751
DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expressionQ33815575
Central nervous system complications in human herpesvirus-6 infectionQ33966140
A population-based study of primary human herpesvirus 6 infectionQ34397270
Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinaseQ34555781
Evidence linking HHV-6 with multiple sclerosis: an updateQ34722731
An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiationQ35065850
A human herpesvirus 6A-encoded microRNA: role in viral lytic replicationQ35076734
ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1Q35107434
Replication of herpes simplex virus 1 depends on the gamma 134.5 functions that facilitate virus response to interferon and egress in the different stages of productive infectionQ35123297
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-Q35964369
Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein responseQ36086646
Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivoQ36092079
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infectionQ36432681
Classification of HHV-6A and HHV-6B as distinct viruses.Q36570863
Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNAQ36641030
Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodiesQ36650951
Structure and function of the protein kinase R.Q36985398
PERK and PKR: old kinases learn new tricksQ37140418
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell deathQ37145200
Regulation of protein synthesis in rabbit reticulocyte lysates: Additional initiation factor required for formation of ternary complex (eIF-2·GTP·Met-tRNA f ) and demonstration of inhibitory effect of heme-regulated protein kinaseQ37319393
Translational regulation mechanisms of AP-1 proteinsQ37376767
Differentiation between two distinct classes of viruses now classified as human herpesvirus 6.Q37544461
Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus productionQ37567845
Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.Q37629201
Small molecule modulators of eukaryotic initiation factor 2α kinases, the key regulators of protein synthesis.Q38128493
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinaseQ38318400
Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know.Q38444117
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.Q39321563
P4510describes a project that usesImageQuantQ112270642
P433issue9
P577publication date2017-02-15
P1433published inJournal of VirologyQ1251128
P1476titleHuman Herpesvirus 6A Exhibits Restrictive Propagation with Limited Activation of the Protein Kinase R-eIF2α Stress Pathway
P478volume91

Search more.