Both Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells

scientific article

Both Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2174/1874357901408010001
P932PMC publication ID4009744
P698PubMed publication ID24799968
P5875ResearchGate publication ID262076467

P50authorKatarzyna GawlikQ90469669
P2093author name stringUdayan Chatterji
Philippe Gallay
Michael Bobardt
Precious Lim
P2860cites workCompletion of the entire hepatitis C virus life cycle in genetically humanized miceQ37382399
Development of novel antiviral therapies for hepatitis C virusQ37801585
New direct-acting antivirals in the development for hepatitis C virus infectionQ37823323
New hepatitis C therapies in clinical developmentQ37911056
Arrest all accessories--inhibition of hepatitis C virus by compounds that target host factors.Q37940114
Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agentsQ37968485
Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding proteinQ38321693
The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infectionQ39378324
Cyclophilin, a primary molecular target for cyclosporine. Structural and functional implicationsQ39516228
Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinaseQ40858827
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitorsQ40998392
New antiviral agents for hepatitis CQ42105512
Treatment of chronic hepatitis C with consensus interferon: a multicenter, randomized, controlled trial. Consensus Interferon Study GroupQ42984733
The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.Q43046668
A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C.Q43048199
The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.Q48033815
Polyinosinic-cytidylic acid complex (poly I:C) and viral infections in mice.Q54062493
Emerging drugs for hepatitis CQ57271196
Safety, pharmacokinetics, and antiviral activity of the cyclophilin inhibitor NIM811 alone or in combination with pegylated interferon in HCV-infected patients receiving 14 days of therapyQ83263799
Epidemiology of hepatitis C virus infectionQ22305500
Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5AQ24303838
Curing a viral infection by targeting the host: the example of cyclophilin inhibitorsQ26828727
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulationQ27469500
Robust hepatitis C virus infection in vitroQ27470013
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter VirusesQ27473226
Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA ReplicationQ27485448
Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and BQ27488369
Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication ComplexQ27488788
Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage KineticsQ27489037
The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus ReplicationQ27489053
Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5AQ27491303
Global epidemiology of hepatitis C virus infectionQ27860799
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Complete replication of hepatitis C virus in cell cultureQ27860934
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypesQ27861119
Hepatitis C virus controls interferon production through PKR activationQ28473895
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5AQ28748683
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
Cyclophilin inhibitors for the treatment of HCV infection.Q30318599
Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteinsQ33711743
Regulation of PKR by HCV IRES RNA: importance of domain II and NS5AQ33987197
Epidemiology of hepatitis C virus (HCV) infectionQ33995067
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylationQ34000124
Profile of alisporivir and its potential in the treatment of hepatitis C.Q34329744
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.Q35063336
American Gastroenterological Association technical review on the management of hepatitis C.Q36364156
Treating viral hepatitis C: efficacy, side effects, and complicationsQ36564615
Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKRQ36655674
Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activitiesQ36656593
Current and future management of chronic hepatitis C infectionQ37143005
P304page(s)1-8
P577publication date2014-03-07
P1433published inThe open virology journalQ27722048
P1476titleBoth Cyclophilin Inhibitors and Direct-Acting Antivirals Prevent PKR Activation in HCV-Infected Cells
P478volume8