Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

scientific article

Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema is …
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scholarly articleQ13442814

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P356DOI10.1016/J.OPHTHA.2010.02.031
P932PMC publication ID2937272
P698PubMed publication ID20427088

P50authorRoy W. BeckQ88156417
Kellee M MillerQ88663907
Diabetic Retinopathy Clinical Research NetworkQ98806904
Adam R GlassmanQ98807054
Ingrid U. ScottQ108861392
Neil M. BresslerQ112187433
Susan B BresslerQ114739669
P2093author name stringFrederick L Ferris
Lloyd Paul Aiello
Michael J Elman
Allison R Edwards
Cynthia R Stockdale
Scott M Friedman
Jennifer K Sun
P2860cites workVascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumorsQ78101810
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A computerized method of visual acuity testing: adaptation of the early treatment of diabetic retinopathy study testing protocolQ44178716
Intravitreal bevacizumab in active progressive proliferative diabetic retinopathyQ46434222
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Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathyQ46927800
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Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research groupQ69874090
Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research GroupQ70215925
The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edemaQ70741925
Ten-year incidence of visual loss in a diabetic populationQ72006850
P433issue6
P921main subjectlaserQ38867
diabetic macular edemaQ18558081
P304page(s)1064-1077.e35
P577publication date2010-04-28
P1433published inOphthalmologyQ7098109
P1476titleRandomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
P478volume117

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Q34282654Intravitreal ranibizumab (lucentis) for the treatment of diabetic macular edema: a systematic review and meta-analysis of randomized clinical control trials
Q31100308Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results
Q35126845Intravitreal ranibizumab for subfoveal choroidal neovascularization from age-related macular degeneration with combined severe diabetic retinopathy
Q36951178Intravitreal triamcinolone acetonide: a "real world" analysis of visual acuity, pressure and outcomes
Q33841803Intravitreal versus sub-tenon posterior triamcinolone injection in bilateral diffuse diabetic macular edema
Q58762930Investigating the Fractal Dimension of the Foveal Microvasculature in Relation to the Morphology of the Foveal Avascular Zone and to the Macular Circulation in Patients With Type 2 Diabetes Mellitus
Q39699517Kernel regression based segmentation of optical coherence tomography images with diabetic macular edema.
Q35631284Kinetics of central macular thickness reduction in patients with macular edema after intravitreal drug therapy
Q35353446Laser-based strategies to treat diabetic macular edema: history and new promising therapies
Q42725230Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress
Q28292764Long-term effectiveness of ranibizumab for age-related macular degeneration and diabetic macular edema
Q87434308Long-term effectiveness of vitrectomy in diabetic cystoid macular edema
Q57288658Long-term efficacy and duration of action of dexamethasone implant, in vitrectomised and non-vitrectomised eyes with persistent diabetic macular oedema
Q35649482Long-term follow-up of intravitreal bevacizumab in retinal arterial macroaneurysm: a case report
Q89710210Long-term results of a single injection of intravitreal dexamethasone as initial therapy in diabetic macular edema
Q57920483Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study
Q48579709Management of diabetic macular edema in Japan: a review and expert opinion.
Q62493181Management of diabetic retinopathy
Q35909406Management of retinal vascular diseases: a patient-centric approach
Q34000861Managing diabetic macular edema: The leading cause of diabetes blindness
Q39009395Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy
Q33855386Medical management of diabetic retinopathy: fenofibrate and ACCORD Eye studies
Q96950831Microperimetry and mfERG as functional measurements in diabetic macular oedema undergoing intravitreal ranibizumab treatment
Q37879581Microvascular modifications in diabetic retinopathy
Q39867113Modelling the cost-effectiveness of adopting risk-stratified approaches to extended screening intervals in the national diabetic retinopathy screening programme in Scotland.
Q57183608Molecular Mechanisms Mediating Diabetic Retinal Neurodegeneration: Potential Research Avenues and Therapeutic Targets
Q36296789Molecular pathogenesis of retinal and choroidal vascular diseases
Q37457142Month-6 primary outcomes of the READ-3 study (Ranibizumab for Edema of the mAcula in Diabetes-Protocol 3 with high dose).
Q28078199Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy
Q34560679Navigated macular laser decreases retreatment rate for diabetic macular edema: a comparison with conventional macular laser
Q38050159Neuropeptides and diabetic retinopathy
Q26765468New Diagnostic and Therapeutic Approaches for Preventing the Progression of Diabetic Retinopathy
Q33583037New Therapeutic Approaches in Diabetic Retinopathy
Q26853239New approaches for the treatment of diabetic macular oedema: recommendations by an expert panel
Q33608021Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside
Q35751912Novel Therapies in Development for Diabetic Macular Edema
Q34313113Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction
Q27002622Novel pharmacotherapies in diabetic retinopathy
Q28066675Novel pharmacotherapies in diabetic retinopathy: Current status and what's in the horizon?
Q49380314Novel therapeutic targets in diabetic macular edema: Beyond VEGF.
Q36217864OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF DIABETIC RETINOPATHY.
Q35049903Ocular complications of diabetes mellitus
Q38018840Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Q36167529Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response
Q24186424Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy
Q24235325Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy
Q35205992Optical coherence tomography-guided selective focal laser photocoagulation: a novel laser protocol for diabetic macular edema
Q64882207Out of darkness comes light-is there a role for light masks in treatment of diabetic macular oedema?
Q39941359Outcomes of intravitreal anti-VEGF therapy in eyes with both neovascular age-related macular degeneration and diabetic retinopathy
Q39269643Oxidative stress and diabetic retinopathy: development and treatment
Q34501650Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial
Q33949871Panretinal photocoagulation (PRP) versus PRP plus intravitreal ranibizumab for high-risk proliferative diabetic retinopathy
Q34528134Pathophysiology and treatment of diabetic retinopathy
Q38372446Patients' preferences for involvement in the decision-making process for treating diabetic retinopathy
Q48021083Patterns of retinal thickness prior to and following treatment with fluocinolone acetonide 190 µg intravitreal implant for diabetic macular edema
Q41789955Peripapillary nerve fiber layer thickness changes after macular photocoagulation for clinically significant diabetic macular edema
Q35889168Persistent Macular Thickening After Ranibizumab Treatment for Diabetic Macular Edema With Vision Impairment
Q50215366Persistent Macular Thickening Following Intravitreous Aflibercept, Bevacizumab, or Ranibizumab for Central-Involved Diabetic Macular Edema With Vision Impairment: A Secondary Analysis of a Randomized Clinical Trial.
Q41091625Persistent suppression of ocular neovascularization with intravitreal administration of AAVrh.10 coding for bevacizumab
Q26786012Perspective on the role of Ozurdex (dexamethasone intravitreal implant) in the management of diabetic macular oedema
Q35173079Pharmacokinetic evaluation of pegaptanib octasodium for the treatment of diabetic edema
Q58697579Pharmacological Management of Diabetic Macular Edema in Real-Life Observational Studies
Q39645541Physician-Industry Interactions and Anti-Vascular Endothelial Growth Factor Use Among US Ophthalmologists
Q85668055Planned foveal detachment technique for the resolution of diffuse diabetic macular edema
Q36104687Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
Q35797036Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats
Q90635817Plume Sign in the Deturgescence of Macular Cysts - A Novel OCT Finding
Q36977005Predicted impact of extending the screening interval for diabetic retinopathy: the Scottish Diabetic Retinopathy Screening programme
Q38845769Predicting outcomes to anti-vascular endothelial growth factor (VEGF) therapy in diabetic macular oedema: a review of the literature.
Q68641918Prediction of Anti-VEGF Response in Diabetic Macular Edema After 1 Injection
Q35221188Prediction, by retinal location, of the onset of diabetic edema in patients with nonproliferative diabetic retinopathy
Q64268367Predictor of Early Remission of Diabetic Macular Edema under As-Needed Intravitreal Ranibizumab
Q36763152Prospective study of inflammatory biomarkers and risk of diabetic retinopathy in the diabetes control and complications trial
Q39222559Protective effects of Lingguizhugan decoction on amyloid-beta peptide (25-35)-induced cell injury: Anti-inflammatory effects
Q35976653Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo
Q90311340Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy
Q35649867RANIBIZUMAB PLUS PROMPT OR DEFERRED LASER FOR DIABETIC MACULAR EDEMA IN EYES WITH VITRECTOMY BEFORE ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY.
Q91387329Randomised trial of wide-field guided PRP for diabetic macular oedema treated with ranibizumab
Q34440571Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy
Q35054240Randomized clinical trials in diabetic macular edema
Q33843242Randomized trial evaluating short-term effects of intravitreal ranibizumab or triamcinolone acetonide on macular edema after focal/grid laser for diabetic macular edema in eyes also receiving panretinal photocoagulation
Q41939283Ranibizumab for Visual Impairment due to Diabetic Macular Edema: Real-World Evidence in the Italian Population (PRIDE Study).
Q88312497Ranibizumab in Diabetic Macular Oedema - A Benefit-risk Analysis of Ranibizumab 0.5 mg PRN Versus Laser Treatment
Q37417759Ranibizumab in diabetic macular edema
Q36615673Ranibizumab in patients with dense cataract and proliferative diabetic retinopathy with rubeosis
Q39292954Ranibizumab in the Treatment of Diabetic Macular Edema: A Review of the Current Status, Unmet Needs, and Emerging Challenges
Q34037627Ranibizumab in the treatment of patients with visual impairment due to diabetic macular edema.
Q35534298Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema: a meta-analysis of randomized controlled trials
Q34410824Ranibizumab, verteporfin photodynamic therapy or observation for the treatment of myopic choroidal neovascularization: cost effectiveness in the UK.
Q34166795Ranibizumab: in diabetic macular oedema
Q33659440Rates of referable eye disease in the Scottish National Diabetic Retinopathy Screening Programme.
Q34089742Rationale for the diabetic retinopathy clinical research network treatment protocol for center-involved diabetic macular edema
Q42835669Re: Changing Trends in the Management of Diabetic Macular Edema at a Single Institution Over the Past Decade
Q90975604Real-world management and long-term outcomes of diabetic macular oedema with good visual acuity
Q64911569Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study.
Q35935370Recent advancements in diabetic retinopathy treatment from the Diabetic Retinopathy Clinical Research Network
Q47168388Recent advances in the management and understanding of diabetic retinopathy
Q28084139Recent developments in laser treatment of diabetic retinopathy
Q39171694Recognising and managing diabetic retinopathy
Q37968572Regenerative nanomedicine and the treatment of degenerative retinal diseases
Q35603578Regression of early diabetic macular oedema is associated with prevention of dark adaptation
Q33563100Relation between macular morphology and treatment frequency during twelve months with ranibizumab for diabetic macular edema
Q44043489Relationship between diabetic retinopathy, diabetic macular oedema and erectile dysfunction in type 2 diabetics
Q92003416Relationship between duration and extent of oedema and visual acuity outcome with ranibizumab in diabetic macular oedema: A post hoc analysis of Protocol I data
Q64907150Repeatability and reproducibility of retinal and choroidal thickness measurements in Diabetic Macular Edema using Swept-source Optical Coherence Tomography.
Q35568276Repeated intravitreous ranibizumab injections for diabetic macular edema and the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment
Q95410568Reply
Q39010176Report of 12-months efficacy and safety of intravitreal fluocinolone acetonide implant for the treatment of chronic diabetic macular oedema: a real-world result in the United Kingdom
Q35012475Reproducibility of Optovue RTVue Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Zeiss Stratus Metrics in Diabetic Macular Edema
Q35198501Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema
Q38002135Retinal neuropathy precedes vasculopathy in diabetes: a function-based opportunity for early treatment intervention?
Q37122850Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes
Q42367664Reversible retinal vessel closure from VEGF-induced leukocyte plugging
Q92594491Role of Inflammation in Classification of Diabetic Macular Edema by Optical Coherence Tomography
Q33730079Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study
Q59808570Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries
Q36093262Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study
Q38021421Screening for diabetic retinopathy and diabetic macular edema in the United Kingdom
Q38130162Screening, prevention, and ambitious management of diabetic macular edema in patients with type 1 diabetes
Q42126619Short-term Efficacy of Intravitreal Dexamethasone Implant in Vitrectomized Eyes with Recalcitrant Diabetic Macular Edema and Prior Anti-VEGF Therapy
Q36307731Short-term effects of intravitreal ranibizumab therapy on diabetic macular edema
Q35344194Side-effects and complications of laser treatment in diabetic retinal disease
Q38104680Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema
Q38963936Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Q41393449Strategy for the management of diabetic macular edema: the European vitreo-retinal society macular edema study.
Q34980970Structural and functional measures of efficacy in response to bevacizumab monotherapy in diabetic macular oedema: exploratory analyses of the BOLT study (report 4).
Q38145185Structural changes in individual retinal layers in diabetic macular edema
Q38964388Sub-Tenon Injections of Triamcinolone Acetonide Had Limited Effect on Cystoid Macular Edema Secondary to Nanoparticle Albumin-Bound-Paclitaxel (Abraxane).
Q35147159Subthreshold diode-laser micropulse photocoagulation as a primary and secondary line of treatment in management of diabetic macular edema
Q90141414Surgical Innovations in the Treatment of Diabetic Macular Edema and Diabetic Retinopathy
Q38177288Surgical treatment for macular edema
Q28817495Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown
Q89531841Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles
Q50872004Switching therapy from bevacizumab to aflibercept for the management of persistent diabetic macular edema.
Q34062494Switching to less expensive blindness drug could save medicare part B $18 billion over a ten-year period
Q26823985Systematic review and mixed treatment comparison of intravitreal aflibercept with other therapies for diabetic macular edema (DME)
Q91842400Systemic Factors Associated with Treatment Response in Diabetic Macular Edema
Q38630749TREATMENT PATTERNS AND 2-YEAR VISION OUTCOMES WITH BEVACIZUMAB IN DIABETIC MACULAR EDEMA: An Analysis From a Large U.S. Integrated Health Care System
Q46407140Ten years of anti-vascular endothelial growth factor therapy
Q37510708The Anti-VEGF Epidemic: What are the Implications for Glaucoma Services?
Q38902223The Efficacy and Safety of Current Treatments in Diabetic Macular Edema: A Systematic Review and Network Meta-Analysis
Q90409273The Evolving Treatment of Diabetic Retinopathy
Q42920003The Optic UK Lecture: bench-to-bedside adventures of a diabetes researcher: results past, results present
Q55078881The RELATION study: efficacy and safety of ranibizumab combined with laser photocoagulation treatment versus laser monotherapy in NPDR and PDR patients with diabetic macular oedema.
Q47099972The Role of Focal Laser in the Anti-Vascular Endothelial Growth Factor Era.
Q35950857The Role of Plasma Kallikrein-Kinin Pathway in the Development of Diabetic Retinopathy: Pathophysiology and Therapeutic Approaches
Q39103989The United Kingdom Diabetic Retinopathy Electronic Medical Record Users Group, Report 1: baseline characteristics and visual acuity outcomes in eyes treated with intravitreal injections of ranibizumab for diabetic macular oedema.
Q26783404The Vitreomacular Interface in Diabetic Retinopathy
Q26783575The clinical utility of aflibercept for diabetic macular edema
Q35947430The combination of phacoemulsification surgery and intravitreal triamcinolone injection in patients with cataract and diabetic macular edema
Q55087230The development of a reference database with the Topcon 3D OCT-1 Maestro.
Q36425846The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats
Q90197758The impact of artificial intelligence in the diagnosis and management of glaucoma
Q34957921The management of diabetic macular oedema
Q34149599The pathogenesis of early retinal changes of diabetic retinopathy
Q34220590The potential of nanomedicine therapies to treat neovascular disease in the retina.
Q51165637The primary care physician's role in preventing vision loss and blindness in patients with diabetes.
Q34378757The relative clinical effectiveness of ranibizumab and bevacizumab in diabetic macular oedema: an indirect comparison in a systematic review
Q26798348The role of aflibercept in the management of diabetic macular edema
Q84789086The role of macular hydration in the evaluation of the effect of intravitreal triamcinolone on visual acuity in eyes with diabetic macular edema
Q26849299The therapeutic potential of intraocular depot steroid systems: developments aimed at prolonging duration of efficacy
Q36280656Therapeutic Options in Refractory Diabetic Macular Oedema
Q43522930Three-dimensional imaging of the inner limiting membrane folding on the vitreomacular interface in diabetic macular edema
Q45335472Time required for navigated macular laser photocoagulation treatment with the Navilas
Q53412660Topical dexamethasone γ-cyclodextrin nanoparticle eye drops increase visual acuity and decrease macular thickness in diabetic macular oedema.
Q36573796Topical pazopanib blocks VEGF-induced vascular leakage and neovascularization in the mouse retina but is ineffective in the rabbit
Q90754697Translating evidence into practice: recommendations by a UK expert panel on the use of aflibercept in diabetic macular oedema
Q37806321Treatment of diabetic retinopathy with anti-VEGF drugs
Q59126156Treatment patterns in diabetic macular edema in Taiwan: a retrospective chart review
Q35870506Treatment strategies for refractory diabetic macular edema: switching anti-VEGF treatments, adopting corticosteroid-based treatments, and combination therapy
Q35933773Trends in the Care of Diabetic Macular Edema: Analysis of a National Cohort
Q34213181Triple therapy: Phaco-vitrectomy with ILM peeling, retinal endophotocoagulation, and intraoperative use of bevacizumab for diffuse diabetic macular edema.
Q42150402Two year result of intravitreal bevacizumab for diabetic macular edema using treat and extend protocol
Q36167145Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema.
Q57300760Ultra-wide optical coherence tomography angiography in diabetic retinopathy
Q33790255Upcoming therapeutic advances in diabetic macular edema: an intravitreal dexamethasone drug delivery system
Q28074846Update on corticosteroids for diabetic macular edema
Q36371395Update on risk of endophthalmitis after intravitreal drug injections and potential impact of elimination of topical antibiotics
Q35578747Updates in the management of diabetic macular edema
Q26767100Updates on the Clinical Trials in Diabetic Macular Edema
Q92860697Ursodeoxycholic Acid Attenuates the Retinal Vascular Abnormalities in Anti-PDGFR-β Antibody-Induced Pericyte Depletion Mouse Models
Q47243737VEGF-A gene polymorphisms and responses to intravitreal ranibizumab treatment in patients with diabetic macular edema.
Q34518374VEGF: From Discovery to Therapy: The Champalimaud Award Lecture.
Q34869372Validity of self-report in type 1 diabetic subjects for laser treatment of retinopathy
Q30244247Vascular Endothelial Growth Factor Inhibitors for Diabetic Retinopathy
Q36338786Vascular Safety of Ranibizumab in Patients With Diabetic Macular Edema: A Pooled Analysis of Patient-Level Data From Randomized Clinical Trials
Q38153731Vascular endothelial growth factor gene polymorphisms and vitreous proteome changes in diabetic retinopathy
Q38829399Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema.
Q96305369Visual and anatomic outcomes of sustained single agent anti-VEGF treatment versus double anti-VEGF switching in the treatment of persistent diabetic macular edema
Q37772801Visual dysfunction associated with diabetic retinopathy
Q48268398Visual improvement following continuous positive airway pressure therapy in diabetic subjects with clinically significant macular oedema and obstructive sleep apnoea: proof of principle study.
Q36203135Visual outcome of laser treatment in diabetic macular edema: Study from an Urban Diabetes Care Center
Q34752779Vitrectomy combined with intravitreal triamcinolone acetonide injection and macular laser photocoagulation for nontractional diabetic macular edema
Q40918766Vitrectomy for center-involved diabetic macular edema
Q47166322Vitreoretinal interface abnormalities in diabetic macular edema and effectiveness of anti-VEGF therapy: an optical coherence tomography study
Q37719142Vitreoretinal interface abnormalities in patients treatedwith ranibizumab for diabetic macular oedema
Q83907682[Diabetic retinopathy and maculopathy]
Q85725384[Diagnosis, therapy and follow up of diabetic eye disease]
Q36257726β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression

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