Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy

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Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy is …
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scholarly articleQ13442814

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P356DOI10.1002/HIPO.20594
P932PMC publication ID2801779
P698PubMed publication ID19309040
P5875ResearchGate publication ID24222237

P50authorAshok ShettyQ42600521
Bharathi HattiangadyQ48164192
P2860cites workExercise enhances learning and hippocampal neurogenesis in aged mice.Q24537320
Neurogenesis may relate to some but not all types of hippocampal-dependent learningQ24629342
Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsyQ24641845
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Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuitQ28216593
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampusQ28236724
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Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoQ28577046
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressantsQ29547516
Functional neurogenesis in the adult hippocampusQ29618708
Wnt signalling regulates adult hippocampal neurogenesisQ29619688
Neurogenesis in the adult is involved in the formation of trace memoriesQ29622890
Beneficial effects of enriched environment following status epilepticus in immature rats.Q30332214
Spatial relational memory requires hippocampal adult neurogenesisQ33338471
Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesisQ33717296
Entorhinal axons exhibit sprouting in CA1 subfield of the adult hippocampus in a rat model of temporal lobe epilepsyQ34146609
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Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampusQ34424431
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Potential role for adult neurogenesis in the encoding of time in new memories.Q34531656
Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus.Q34576049
Memory impairment in temporal lobe epilepsy: the role of entorhinal lesionsQ34768837
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Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus.Q36729208
Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy.Q36729217
Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy.Q36729229
The pilocarpine model of temporal lobe epilepsyQ36841686
Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy.Q36850236
Adult hippocampal neurogenesis in depressionQ36921967
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Doublecortin-positive newly born granule cells of hippocampus have abnormal apical dendritic morphology in the pilocarpine model of temporal lobe epilepsy.Q39806372
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Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat.Q42455434
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Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitryQ42495522
Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells.Q42515771
Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neuronsQ43611984
Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesisQ43807507
Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.Q43939477
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsyQ44056599
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Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sproutingQ44581779
Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizuresQ44633580
Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrusQ44729784
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.Q44972977
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult ratsQ45063826
Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy.Q45121641
Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus.Q45168388
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damageQ45173236
Advances in understanding the process of epileptogenesis based on patient material: what can the patient tell us?Q46169515
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.Q46402795
Might astrocytes play a role in maintaining the seizure-prone state?Q46483085
Dynamics of neurogenesis in the dentate gyrus of adult ratsQ46557470
Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats.Q46603768
Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.Q46703426
Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizuresQ46785506
Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administrationQ46842547
CA3 axonal sprouting in kainate-induced chronic epilepsyQ46855098
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.Q46956867
Enhanced production and dendritic growth of new dentate granule cells in the middle-aged hippocampus following intracerebroventricular FGF-2 infusions.Q46990503
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsyQ48154139
Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampusQ48164120
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsyQ48201269
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus.Q48285420
Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitabilityQ48333832
Balance between neurogenesis and gliogenesis in the adult hippocampus: role for reelinQ48346671
The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampusQ48356919
Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat.Q48381408
Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesisQ48381438
Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patientsQ48393655
Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrusQ48925056
Seizures accelerate functional integration of adult-generated granule cells.Q50733781
Depressed mood and memory impairment in temporal lobe epilepsy as a function of focus lateralization and localization.Q50992124
Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy.Q52002944
Differential impairments of spatial memory and social behavior in two models of limbic epilepsy.Q52051528
Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis.Q52166176
Increased number of neural progenitors in human temporal lobe epilepsy.Q53666144
Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cellsQ63433214
Mossy fiber synaptic reorganization in the epileptic human temporal lobeQ69240649
Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the ratQ69591953
Inhibition in kainate-lesioned hyperexcitable hippocampi: physiologic, autoradiographic, and immunocytochemical observationsQ69830690
Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsyQ73258578
P433issue1
P921main subjecttemporal lobe epilepsyQ616667
neurogenesisQ1456827
P304page(s)97-112
P577publication date2010-01-01
P1433published inHippocampusQ5768411
P1476titleDecreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy
P478volume20

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cites work (P2860)
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