A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis

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A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1000989119
P356DOI10.1038/NRC3601
P932PMC publication ID4011841
P698PubMed publication ID24108097

P2093author name stringJames R Goldenring
P2860cites workIdentification of a novel Rab11/25 binding domain present in Eferin and Rip proteinsQ24291502
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transportQ24295585
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironmentsQ24296948
The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structureQ24305115
In vitro reconstitution of a transport complex containing Rab27a, melanophilin and myosin VaQ24307247
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancersQ24308778
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesisQ24311615
Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesisQ24321408
The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.Q24322791
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrinsQ24338894
SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.Q42828070
Characterization of the Rab8-specific membrane traffic route linked to protrusion formationQ42833672
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexesQ42965638
Tumor suppressor function of Rab25 in triple-negative breast cancerQ43268763
SDF-1-CXCR4 axis: cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinomaQ44697231
Rabs and cancer cell motility.Q46024083
New perspectives on mechanisms involved in generating epithelial cell polarityQ46889799
Increased expression of Rab25 in breast cancer correlates with lymphatic metastasisQ47695138
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.Q47701291
Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.Q50495495
Navajo microvillous inclusion disease is due to a mutation in MYO5B.Q54507972
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migrationQ57041202
Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in MiceQ58363144
Rab GTPases at a glanceQ81566767
Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cellsQ83892051
Do GTPases direct membrane traffic in secretion?Q39209893
The plasma membrane sialidase NEU3 regulates the malignancy of renal carcinoma cells by controlling β1 integrin internalization and recyclingQ39247356
Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancerQ39291111
Distinct recycling of active and inactive β1 integrinsQ39417083
Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migrationQ39457461
Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulinQ39473988
Rab5A is associated with axillary lymph node metastasis in breast cancer patientsQ39479005
Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transferQ39489538
Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosisQ39551949
Mutant p53 drives invasion by promoting integrin recyclingQ39753731
Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPaseQ39809153
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.Q39868851
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.Q39969514
Loss of RAB25 expression in breast cancerQ40333480
Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.Q40446586
Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosomeQ40826327
Transferrin receptor polarity and recycling accuracy in "tight" and "leaky" strains of Madin-Darby canine kidney cellsQ41513093
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule levelQ41978648
Planar cell polarity controls directional Notch signaling in the Drosophila leg.Q42214750
Endocytic control of epithelial polarity and proliferation in DrosophilaQ42485957
Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5Q24533195
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc geneQ24562061
Myosin vb is associated with plasma membrane recycling systemsQ24633656
Epithelial cell polarity: a major gatekeeper against cancer?Q24635870
Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectodermQ27336491
Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in DrosophilaQ27347573
The GTPase superfamily: conserved structure and molecular mechanismQ27860524
Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivoQ27919683
Coordination of Rab8 and Rab11 in primary ciliogenesisQ27967674
A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesisQ28000096
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9Q28115891
Identification and characterization of a family of Rab11-interacting proteinsQ28211889
RCP is a human breast cancer-promoting gene with Ras-activating functionQ28252569
Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cellsQ28293127
The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome traffickingQ28507551
Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recyclingQ28574079
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.Q30479122
Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.Q30479902
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarityQ30485266
MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matricesQ30492127
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivoQ30524194
Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling systemQ30536894
Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complexQ31115300
Aberrant expression of RAB1A in human tongue cancer.Q33214689
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomasQ33685634
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptorQ33886791
The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?Q34184029
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressorQ34264864
Deregulation of Rab and Rab effector genes in bladder cancer.Q34314461
Sec15 is an effector for the Rab11 GTPase in mammalian cellsQ34338417
The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling systemQ34558878
Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activationQ34735845
E-cadherin germline mutations in familial gastric cancer.Q34746744
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.Q34812873
Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells.Q34884392
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migrationQ35130176
Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear falloutQ35161159
Regulation of epithelial cell polarity: a view from the cell surfaceQ35241240
Polarity of epithelial and neuronal cellsQ35651750
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.Q35694156
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cellsQ35750120
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in miceQ35780286
Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteinsQ35950439
Coordinated protein sorting, targeting and distribution in polarized cellsQ36015653
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cellsQ36016985
The epithelium in inflammatory bowel disease: potential role of endocytosis of junctional proteins in barrier disruptionQ36019639
Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethalityQ36119027
Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomesQ36234135
Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarityQ36256216
Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion moleculesQ36382508
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.Q36426956
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.Q36619492
Rab25 regulates integrin expression in polarized colonic epithelial cellsQ36680569
Rab25 regulates invasion and metastasis in head and neck cancer.Q36698584
Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexesQ36745372
Transformation of polarized epithelial cells by apical mistrafficking of epiregulinQ36895691
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.Q36914211
Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosomeQ37003924
Alternative splicing in class V myosins determines association with Rab10.Q37036487
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotypeQ37345502
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patientQ37565544
Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.Q37582684
Epithelial organization, cell polarity and tumorigenesisQ37904131
Rab8 GTPase as a regulator of cell shapeQ37919430
Illuminating the functional and structural repertoire of human TBC/RABGAPs.Q37976530
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancerQ38290004
MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14).Q38337024
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcarcinogenesisQ1637543
P304page(s)813-820
P577publication date2013-10-10
P1433published inNature Reviews CancerQ641657
P1476titleA central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis
P478volume13

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