Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity

scientific article

Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-09-1555
P932PMC publication ID2802655
P698PubMed publication ID20028759

P50authorMotofumi TanakaQ90953497
Milind JavleQ92719947
Donghui LiQ112692814
James Lewis AbbruzzeseQ14947937
P2093author name stringTaro Okazaki
P2860cites workGemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolismQ71542211
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphismQ79460532
Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1)Q79955361
Gemcitabine pharmacogenomics: cytidine deaminase and deoxycytidylate deaminase gene resequencing and functional genomicsQ82903101
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase geneQ24794747
Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.Q27863396
Assessing the probability that a positive report is false: an approach for molecular epidemiology studiesQ29616285
A "silent" polymorphism in the MDR1 gene changes substrate specificityQ29619435
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cellsQ29937967
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.Q33238550
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatinQ33365727
Cellular pharmacology of gemcitabineQ34542801
Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).Q34750366
Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer.Q36464111
Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?Q36610851
Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancerQ37158252
Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic headQ40068712
Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cellsQ40319699
Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancerQ40506711
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.Q44245520
A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity.Q44289169
Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathwayQ44956846
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.Q45122012
Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patientsQ45163411
Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1Q46042363
Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic headQ46473461
Functional single nucleotide polymorphism haplotypes in the human equilibrative nucleoside transporter 1.Q46491555
Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoterQ46919608
Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia.Q54109043
Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreasQ67523718
2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductaseQ70215052
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
single-nucleotide polymorphismQ501128
P304page(s)320-329
P577publication date2009-12-22
P1433published inClinical Cancer ResearchQ332253
P1476titleSingle nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
P478volume16

Reverse relations

cites work (P2860)
Q36600132A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival
Q53266946ATP assay-guided chemosensitivity testing for gemcitabine with biopsy specimens obtained from unresectable pancreatic cancer using endoscopic ultrasonography-guided fine-needle aspiration.
Q38075827Adjuvant pharmacotherapy in the management of elderly patients with pancreatic cancer
Q48257252An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer.
Q28076342An Overview of Genetic Changes and Risk of Pancreatic Ductal Adenocarcinoma
Q42725709Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.
Q40633085Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients
Q34474400Association of multi‐drug resistance gene polymorphisms with pancreatic cancer outcome
Q35715498Chemotherapy outcomes for the treatment of unresectable intrahepatic and hilar cholangiocarcinoma: a retrospective analysis.
Q47803255Chemotherapy-induced neutropenia and the prognosis of colorectal cancer: a meta-analysis of cohort studies
Q50659752Chemotherapy-induced neutropenia as a prognostic factor in patients with metastatic pancreatic cancer treated with gemcitabine.
Q38747834Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer
Q44546647Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704.
Q47129097DCK expression, a potential predictive biomarker in the adjuvant gemcitabine chemotherapy for biliary tract cancer after surgical resection: results from a phase II study
Q35584339DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer
Q54494355Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine.
Q36342657Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine
Q37876401Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs
Q34254837Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
Q34408283Gemcitabine-based chemoradiotherapy followed by surgery for borderline resectable and locally unresectable pancreatic ductal adenocarcinoma: significance of the CA19-9 reduction rate and intratumoral human equilibrative nucleoside transporter 1 expr
Q35048269Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer
Q38805564Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.
Q28943489Genome-wide association study of survival in patients with pancreatic adenocarcinoma
Q45220444Genomic polymorphisms of SLC29A3 associated with overall survival in advanced non-small-cell lung cancer treated with gemcitabine
Q42486793Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recurrence and survival in pancreatic cancer
Q38698643Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.
Q37342736Human Equilibrative Nucleoside Transporter 1 (hENT1) in Pancreatic Adenocarcinoma: Towards Individualized Treatment Decisions.
Q47102782Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies
Q53653257Impact of single nucleotide polymorphisms of cytarabine metabolic genes on drug toxicity in childhood acute lymphoblastic leukemia.
Q83389944Integrating pharmacogenetics into gemcitabine dosing--time for a change?
Q39250668Molecular predictors of gemcitabine response in pancreatic cancer
Q38842938Nucleoside analogs: ready to enter the era of precision medicine?
Q35066350Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets.
Q49387560Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles
Q38067828Pancreatic cancer - cost for overtreatment with gemcitabine.
Q54494358Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors.
Q42130469Patient-Specific Pluripotent Stem Cells in Doxorubicin Cardiotoxicity: A New Window Into Personalized Medicine
Q36097060Personalized therapy for pancreatic cancer: Myth or reality in 2010?
Q38003703Pharmacogenetics of chemotherapy efficacy in breast cancer
Q30728815Pharmacogenomic characterization of gemcitabine response--a framework for data integration to enable personalized medicine
Q38596926Pharmacogenomics in the treatment of lung cancer: an update
Q26752368Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective
Q41836511Preoperative therapies for resectable and borderline resectable pancreatic cancer
Q36003248Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma
Q38236028Role of solute carrier transporters in pancreatic cancer: a review
Q50053693Severe acute toxicity following gemcitabine administration: A report of four cases with cytidine deaminase polymorphisms evaluation
Q49997308Stemness and anti-cancer drug resistance in ATP-binding cassette subfamily G member 2 highly expressed pancreatic cancer is induced in 3D culture conditions.
Q27021716Systemic therapies for pancreatic cancer--the role of pharmacogenetics
Q36525188Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.
Q28550040The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells
Q43631694The association between neutropenia and prognosis in stage III colorectal cancer patients receiving adjuvant chemotherapy
Q37663396Uptake carriers and oncology drug safety
Q60957982Use of Germline Genetic Variability for Prediction of Chemoresistance and Prognosis of Breast Cancer Patients
Q37207004dCK Expression and Gene Polymorphism With Gemcitabine Chemosensitivity in Patients With Pancreatic Ductal Adenocarcinoma: A Strobe-Compliant Observational Study
Q26862139hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: a systematic review