Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

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Hypoxia, inflammation, and the tumor microenvironment in metastatic disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1039149383
P356DOI10.1007/S10555-010-9224-5
P932PMC publication ID4012531
P698PubMed publication ID20393783

P50authorAmato J. GiacciaQ110591782
P2093author name stringElizabeth C Finger
P2860cites workOxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cellsQ74040126
Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancerQ74448985
Expression of connective tissue growth factor in human renal fibrosisQ74462450
Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?Q77321324
Expression of fibrogenic cytokines in desmoplastic malignant melanomaQ77393461
Connective tissue growth factor gene expression alters tumor progression in esophageal cancerQ77811241
Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancerQ80207404
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitorsQ80344477
Matrix metalloproteinase-9 (MMP-9) elevated in serum but not in bronchial lavage fluid in patients with lung cancerQ83842589
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasisQ83894901
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationQ24291783
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticityQ24297858
Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progressionQ24300340
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progressionQ24314451
Collagenolytic activity in amphibian tissues: a tissue culture assayQ24648397
Inflammation and cancerQ24649640
Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancerQ24650026
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesisQ24669710
Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissuesQ24675315
Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma CellsQ24685207
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationQ27860876
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated MacrophagesQ28143066
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylationQ28188357
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involvedQ28189972
Lysyl oxidases: a novel multifunctional amine oxidase familyQ28201099
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cellQ28208372
A molecular role for lysyl oxidase in breast cancer invasionQ28216721
RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasisQ28236828
The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from boneQ28251134
Lysyl oxidase mediates hypoxic control of metastasisQ28271667
Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinaseQ28279434
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxiaQ28300406
Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in miceQ28510969
Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cellsQ28568824
Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl OxidaseQ29544584
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Cancer statistics, 2009Q29547625
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Stromal fibroblasts in cancer initiation and progressionQ29618873
Basement membranes: structure, assembly and role in tumour angiogenesisQ29622882
An overview of epithelio-mesenchymal transformationQ30014826
Matrix metalloproteinases: a tail of a frog that became a princeQ33337157
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applicationsQ33692926
Infections as a major preventable cause of human cancerQ33916455
The modular architecture of a new family of growth regulators related to connective tissue growth factorQ34306420
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skinQ34570988
Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins.Q35676694
Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative studyQ36087887
Recombinant human erythropoietin in oncology: current status and further developmentsQ36164274
The fallacy of epithelial mesenchymal transition in neoplasiaQ36197878
Ultrastructural immunolocalization of lysyl oxidase in vascular connective tissueQ36215340
Matrix metalloproteinases: role in arthritisQ36251020
Correlation between the tumoral expression of beta3-integrin and outcome in cervical cancer patients who had undergone radiotherapyQ36615716
Hyperbaric oxygen therapy for malignancy: a review.Q36653195
Hypoxia, gene expression, and metastasisQ36801457
Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasisQ37143367
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcriptsQ37285034
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03.Q37347497
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growthQ37353804
Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodelingQ37365541
EMT, the cytoskeleton, and cancer cell invasionQ37377630
Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancerQ37412311
Role of hypoxia in the hallmarks of human cancerQ37500308
Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe?Q37601177
TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasionQ37678189
Hypoxic induction of Ctgf is directly mediated by Hif-1.Q38337618
Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrityQ38596551
Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alphaQ40063538
Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instabilityQ40335526
beta-catenin signaling and regulation of cyclin D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl oxidaseQ40411627
The relationship between bone metastasis from human breast cancer and integrin alpha(v)beta3 expression.Q40437776
Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors.Q40453891
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.Q40731011
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasivenessQ40760011
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell lineQ40772926
Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiationQ41454169
Cancer and infection: estimates of the attributable fraction in 1990.Q41498906
Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.Q41628295
Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.Q41750906
Desmoplastic reaction influences pancreatic cancer growth behaviorQ42468547
A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancerQ42522113
Autocrine transforming growth factor-beta signaling mediates Smad-independent motility in human cancer cells.Q42527689
The proteolytic processing site of the precursor of lysyl oxidase.Q42824263
Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC).Q43264716
Expression of integrin alphaVbeta3 in pancreatic carcinoma: relation to MMP-2 activation and lymph node metastasis.Q44079888
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alphaQ44108492
Lysyl oxidase is required for vascular and diaphragmatic development in miceQ44243394
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomasQ44418604
Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissuesQ45194238
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.Q45969475
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.Q46033311
E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs.Q51531889
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.Q53347755
Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.Q55044320
Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery.Q55474171
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.Q55476886
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cellsQ60609535
Tumor oxygenation and reoxygenation during radiation therapy: their importance in predicting tumor responseQ69491072
Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculatureQ69651963
Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disordersQ71049546
Integrin alpha V beta 3 expression by bone-residing breast cancer metastasesQ71312522
Histone H1 is a substrate for lysyl oxidase and contains endogenous sodium borotritide-reducible residuesQ72561527
Expression of connective tissue growth factor in cartilaginous tumorsQ73025432
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)285-293
P577publication date2010-06-01
P1433published inCancer and Metastasis ReviewsQ2647982
P1476titleHypoxia, inflammation, and the tumor microenvironment in metastatic disease
P478volume29

Reverse relations

cites work (P2860)
Q3579715818F-EF5 PET Is Predictive of Response to Fractionated Radiotherapy in Preclinical Tumor Models
Q3497982118F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243
Q60301430A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines
Q24322269A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
Q92541443A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-Based Photosensitizers: Tumor Microenvironment Adaption and Remodeling
Q30010277A concerted HIF-1α/MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells
Q33889245A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue
Q36040206ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.
Q38114319Acid-sensing ion channels under hypoxia
Q35810840Active roles of tumor stroma in breast cancer metastasis
Q35085751Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation
Q58702062All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells
Q39141556An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines
Q64941725Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp.
Q30399006Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
Q52646033Antitumor effect of a Pt-loaded nanocomposite based on graphene quantum dots combats hypoxia-induced chemoresistance of oral squamous cell carcinoma.
Q47137400BMPR2 and HIF1-α overexpression in resected osteosarcoma correlates with distant metastasis and patient survival
Q37264934BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes
Q40202794BRMS1 gene expression may be associated with clinico-pathological features of breast cancer
Q35600151Bioengineering embryonic stem cell microenvironments for the study of breast cancer
Q89765517Biophysical Regulation of Cancer Stem/Initiating Cells: Implications for Disease Mechanisms and Translation
Q38259683Bone marrow-derived stem cell therapy for metastatic brain cancers
Q37662627CTGF is a therapeutic target for metastatic melanoma.
Q91825034Cancer-educated mesenchymal stem cells promote the survival of cancer cells at primary and distant metastatic sites via the expansion of bone marrow-derived-PMN-MDSCs
Q37106779Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase
Q26851836Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis
Q86911827Characterization of clear cell renal cell carcinoma by gene expression profiling
Q39387590Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia
Q90571077Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development
Q35575974Chronic inflammation and immunologic-based constraints in malignant disease
Q92840556Cisplatin inhibits the growth, migration and invasion of cervical cancer cells by down-regulating IL-17E/IL-17RB
Q37437301Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment
Q92736052Decoding the Biology of Exosomes in Metastasis
Q36261594Decreased expression of mucin 18 is associated with unfavorable postoperative prognosis in patients with clear cell renal cell carcinoma
Q39636162Development path and current status of the NANIVID: a new device for cancer cell studies
Q34218825Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers
Q84972901Differential response to CoCl2-stimulated hypoxia on HIF-1α, VEGF, and MMP-2 expression in ligament cells
Q51079367Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study.
Q36020972Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment
Q47098374Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression
Q42424347Escaping from, moving towards, following a path, squeezing through: lots of opportunities for moving cells
Q34569444Evaluation of characteristics of CD44+CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures
Q28397739Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
Q37001207Expression and clinical significance of glucose transporter-1 in pancreatic cancer
Q37610995Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix.
Q51563028Expression of somatostatin receptor 2A in medullary thyroid carcinoma is associated with lymph node metastasis.
Q38783439Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Q39389732Extracellular Vesicles in Renal Pathophysiology.
Q37580365Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.
Q35938289Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro
Q38867010Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma
Q91755999Fucoidan inhibits epithelial-to-mesenchymal transition via regulation of the HIF-1α pathway in mammary cancer cells under hypoxia
Q34735661Glial progenitors as targets for transformation in glioma
Q92631456Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics
Q40220883H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay
Q33611004HIFs enhance the transcriptional activation and splicing of adrenomedullin
Q54354561Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer.
Q49205660Herbal compound Teng-Long-Bu-Zhong-Tang inhibits metastasis in human RKO colon carcinoma
Q36175681High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
Q30365660High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation.
Q37092893Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats.
Q34820282Hypoxia and the extracellular matrix: drivers of tumour metastasis
Q38935440Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma.
Q35762937Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9
Q35987892Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis
Q47218239Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.
Q47930181Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction.
Q34177914Hypoxia regulates alternative splicing of HIF and non-HIF target genes.
Q27319546Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells.
Q52595311Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.
Q34117013Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK).
Q92372553Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift
Q38051286Hypoxia-inducible factors as key regulators of tumor inflammation
Q37843943Hypoxia-mediated biological control
Q57183552Hypoxia-sensitive bis(2-(2'-benzothienyl)pyridinato-N,C(3'))iridium[poly(n-butyl cyanoacrylate]/chitosan nanoparticles and their phosphorescence tumor imaging in vitro and in vivo
Q93129624Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells
Q44759466Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages
Q64101974Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
Q39377200Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine
Q52561274Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - An illustration with firsthand examples.
Q37784096Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link
Q26770029Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?
Q38501776Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation
Q38311815Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.
Q53173976Intracellular Wnt/Beta-Catenin Signaling Underlying 17beta-Estradiol-Induced Matrix Metalloproteinase 9 Expression in Human Endometriosis.
Q35100014Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Q60961187Isoliquiritin Apioside Suppresses Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
Q38429293LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling
Q64274739Limitations of Anti-Angiogenic Treatment of Tumors
Q85880902Lipoxin A4 suppresses lipopolysaccharide-induced hela cell proliferation and migration via NF-κB pathway
Q41471434Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
Q37987842Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Q39376527Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP.
Q38393014Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes
Q35935026Metabolic abnormalities in pituitary adenoma patients: a novel therapeutic target and prognostic factor
Q28394526Metastasis suppressor genes at the interface between the environment and tumor cell growth
Q35370402Metastasis-associated gene, mag-1 improves tumour microenvironmental adaptation and potentiates tumour metastasis.
Q102141796Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
Q38095501MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer
Q39415390Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro.
Q36917436Modeling the mechanics of cancer: effect of changes in cellular and extra-cellular mechanical properties
Q35064453Molecular and functional imaging of invasion and metastasis: windows into the metastatic cascade
Q34914057Movers and shakers: cell cytoskeleton in cancer metastasis
Q87126886Netrin-1 induces epithelial-mesenchymal transition and promotes hepatocellular carcinoma invasiveness
Q90455622New Directions in the Study and Treatment of Metastatic Cancer
Q93055148Next-Generation Sequencing Panel Analysis of Clinically Relevant Mutations in Circulating Cell-Free DNA from Patients with Gestational Trophoblastic Neoplasia: A Pilot Study
Q89540121Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial
Q48210066Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2.
Q91942285Organizing pneumonia secondary to lung cancer of unknown primary site
Q39135331Oxygen distribution in tumors: a qualitative analysis and modeling study providing a novel Monte Carlo approach.
Q39017204PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells
Q91773961PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α
Q33439635Phase I study of pazopanib plus TH-302 in advanced solid tumors
Q36297745Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation
Q37971591Proline metabolism and cancer
Q28301777Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
Q35185336ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells
Q28068654Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer
Q90277895Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF‑1α pathway
Q58702065Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma
Q92372937Role of the RAB7 Protein in Tumor Progression and Cisplatin Chemoresistance
Q39395549Roles of HIF-1α in a novel optical orthotopic spontaneous metastatic bladder cancer animal model
Q37404757STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
Q31132835STAT3 or USF2 contributes to HIF target gene specificity
Q38743015Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells.
Q33763551Significance of talin in cancer progression and metastasis
Q89367617Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Q57044552Sorafenib inhibits caspase-1 expression through suppressing TLR4/stat3/SUMO1 pathway in hepatocellular carcinoma
Q38172858Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.
Q92977325Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma
Q36581353Symptomatic cardiac metastases of breast cancer 27 years after mastectomy: a case report with literature review--pathophysiology of molecular mechanisms and metastatic pathways, clinical aspects, diagnostic procedures and treatment modalities
Q37093119TLR4 is a novel determinant of the response to paclitaxel in breast cancer
Q57291853Targeted Theranostic Nanoparticles for Brain Tumor Treatment
Q91895956The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis
Q38985464The Solid Mechanics of Cancer and Strategies for Improved Therapy
Q38210012The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer
Q28079015The ever-expanding role of HIF in tumour and stromal biology
Q36972016The metastasis-promoting roles of tumor-associated immune cells
Q35864968The molecular biology of brain metastasis
Q101476066The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression
Q35440270The primary cilium as a biomarker in the hypoxic adaptation of bone marrow-derived mesenchymal stromal cells: a role for the secreted frizzled-related proteins
Q37964960The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma
Q37836613The role of nuclear pore complex in tumor microenvironment and metastasis
Q39439223The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
Q36570909The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
Q37851151Therapeutic targeting of tumor-stroma interactions.
Q30924798Toward predicting metastatic progression of melanoma based on gene expression data
Q48567245Tumor chemosensitization by physical exercise? Insights from an anidmal model.
Q34347257Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis
Q47105842Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma
Q90319010Tumor progression-dependent angiogenesis in gastric cancer and its potential application
Q26747678Tumor refractoriness to anti-VEGF therapy
Q37127042Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Q36362933Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia
Q39285839Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion
Q38219611Wound infections and healing: are they contributing factors for carcinogenesis?
Q39007411c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2.
Q36838575αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells

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