Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine

scientific article

Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084931847
P356DOI10.1038/SREP46621
P932PMC publication ID5395940
P698PubMed publication ID28422178

P50authorAdrian V. S. HillQ22278197
Sarah GilbertQ30513802
Katharine A CollinsQ55175774
Matthew G. CottinghamQ55465134
P2093author name stringRebecca Snaith
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Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protectionQ34990090
Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1 vary by ages of subjects and by season in a highland area of KenyaQ35165581
Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in AfricaQ35428630
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CD8+ T effector memory cells protect against liver-stage malariaQ36055733
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Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challengeQ36313990
Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccineQ36353548
T cells compete for access to antigen-bearing antigen-presenting cellsQ36376071
Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adultsQ36393102
ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humansQ36460499
Tailoring a Combination Preerythrocytic Malaria VaccineQ36631331
Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers Under Chloroquine Prophylaxis: A Randomized Controlled TrialQ36644534
Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in miQ36646698
Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan childrenQ37023939
Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccineQ37151766
Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP.Q37161928
Safety and Immunogenicity of ChAd63 and MVA ME-TRAP in West African Children and InfantsQ37229742
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisationQ37403767
Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite proteinQ37482822
Functional immunoassays using an in-vitro malaria liver-stage infection model: where do we go from here?Q37595803
Prime-boost vectored malaria vaccines: progress and prospectsQ37671502
The whole parasite, pre-erythrocytic stage approach to malaria vaccine development: a reviewQ38132005
Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production.Q38205379
Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trialsQ38599514
Biological role of different antibody classesQ38757590
Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primatesQ39823165
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
malaria vaccineQ6741353
P304page(s)46621
P577publication date2017-04-19
P1433published inScientific ReportsQ2261792
P1476titleEnhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine
P478volume7

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cites work (P2860)
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