Genetic alterations in quadruple malignancies of a patient with multiple sclerosis: their role in malignancy development and response to therapy

scientific article

Genetic alterations in quadruple malignancies of a patient with multiple sclerosis: their role in malignancy development and response to therapy is …
instance of (P31):
case reportQ2782326
scholarly articleQ13442814

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P932PMC publication ID4014273
P698PubMed publication ID24817989

P2093author name stringYasuhiro Ito
Gordana Pupic
Marko Buta
Radan Dzodic
Zorka Milovanovic
Jasna Bankovic
Nikola Tanic
Zorica Milosevic
Dragana Lavrnic
Vedrana Milinkovic
Tijana Stankovic
Sonja Stojkovic
P2860cites workClinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancerQ30318256
RET proto-oncogene in the development of human cancerQ33718087
Cancer incidence in multiple sclerosis and effects of immunomodulatory treatments.Q36064845
Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancerQ36081611
Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.Q36677712
Why is PTEN an important tumor suppressor?Q36986667
Genetic basis for p53 overexpression in human breast cancerQ37528810
Multiple primary malignancies including colon, stomach, lung, breast, and liver cancer: a case report and literature reviewQ37688323
Quadruple malignancy in a single patient: a case report and comprehensive review of literatureQ37771807
Differential oncogenic potential of activated RAS isoforms in melanocytesQ40171561
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikisQ40539659
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblastsQ41205734
Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylationQ41578148
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancersQ41691073
The Ras radiation resistance pathway.Q43612306
The prognostic value of PTEN, p53, and beta-catenin in endometrial carcinoma: a prospective immunocytochemical studyQ44679625
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patientsQ46116622
Loss of heterozygosity for 10q22-10qter in malignant melanoma progressionQ46160835
Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patientsQ46710025
Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancerQ46892013
Sentinel lymph node biopsy may be used to support the decision to perform modified radical neck dissection in differentiated thyroid carcinoma.Q50479592
Concurrent alteration of p16 and PTEN tumor suppressor genes could be considered as potential molecular marker for specific subgroups of NSCLC patients.Q54623612
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomasQ57591220
RET mutation screening in MEN2 patients and discovery of a novel mutation in a sporadic medullary thyroid carcinomaQ71331640
Mutations of codon 918 in the RET proto-oncogene correlate to poor prognosis in sporadic medullary thyroid carcinomasQ71744061
Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanomaQ72234184
Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancerQ72992810
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinomaQ73684859
Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanomaQ73803410
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locusQ74274255
The risk of cancer from azathioprine as a treatment for multiple sclerosisQ75352273
Malignancies after renal transplantation during 33 years at a single centerQ80044617
P433issue4
P921main subjectmultiple sclerosisQ8277
P304page(s)1826-1833
P577publication date2014-03-15
P1433published inInternational Journal of Clinical and Experimental PathologyQ6051341
P1476titleGenetic alterations in quadruple malignancies of a patient with multiple sclerosis: their role in malignancy development and response to therapy
P478volume7

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cites work (P2860)
Q99240834Multiple sclerosis, human herpesvirus 4 and thyroid collision tumor: A case report
Q33788750Two cancers in one: breast carcinoma with underlying melanoma.

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