The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells

scientific article

The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022179240
P356DOI10.1038/ONC.2009.331
P932PMC publication ID2806938
P698PubMed publication ID19838218
P5875ResearchGate publication ID38019365

P50authorSusan E. WaltzQ55324042
P2093author name stringD Gurusamy
M N Thobe
P Pathrose
P2860cites workAltered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potentialQ28203075
ChemokinesQ29616435
Chemokines as mediators of neovascularizationQ30438032
Biological effects of targeted inactivation of hepatocyte growth factor-like protein in miceQ32106841
The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activityQ33181330
Molecular alterations in primary prostate cancer after androgen ablation therapyQ33224548
Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family memberQ33257955
Integrative molecular concept modeling of prostate cancer progression.Q33266777
Natural history of progression after PSA elevation following radical prostatectomyQ33611613
Ron-receptor tyrosine kinase in tumorigenesis and metastasisQ33850098
Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 productionQ33850102
Met-related receptor tyrosine kinase Ron in tumor growth and metastasis.Q33916081
The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humansQ35758261
Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization techniqueQ35764474
Distinct CXC chemokines mediate tumorigenicity of prostate cancer cellsQ35786924
Cancer CXC chemokine networks and tumour angiogenesisQ36410717
Current status of anti-angiogenesis therapy for prostate cancer.Q36469815
Multi-faceted roles for CXC-chemokines in prostate cancer progressionQ37175351
Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxaliplatin through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis.Q39941738
The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.Q40110348
Vasoactive intestinal peptide enhances growth and angiogenesis of human experimental prostate cancer in a xenograft model.Q40125005
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenograftsQ40144642
The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progressionQ40174257
The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growthQ40333696
Clinical prognostic significance of tumour angiogenesisQ40392096
Progressive dysregulation of transcription factors NF-kappa B and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokinesQ40610370
Suppression of tumor growth by viral vector-mediated gene transfer of N-terminal truncated platelet factor 4.Q40614980
Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell linesQ40841807
Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factorQ40959138
Overexpression of the RON gene in human breast carcinomaQ41023826
Angiogenic factors expressed by human prostatic cell lines: effect on endothelial cell growth in vitroQ41088280
Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty.Q42640767
Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasisQ42824776
Leukocyte adhesion molecule and chemokine production through lipoteichoic acid recognition by toll-like receptor 2 in cultured human lymphatic endotheliumQ43710357
Interleukin-8 as a macrophage-derived mediator of angiogenesisQ44053300
Ron receptor signaling augments mammary tumor formation and metastasis in a murine model of breast cancerQ45285566
Genomic profiling reveals alternative genetic pathways of prostate tumorigenesisQ46695435
Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cellsQ46936146
SDF-1 alpha expression during wound healing in the aged is HIF dependent.Q53413492
Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cellsQ56890926
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activationQ57100119
Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progressionQ57693549
Hepatocyte-specific expression of the mouse hepatocyte growth factor-like proteinQ72853763
Vascular density is a predictor of cancer-specific survival in prostatic carcinomaQ73690891
Induction of hepatocyte growth factor in stromal cells by tumor-derived basic fibroblast growth factor enhances growth and invasion of endometrial cancerQ78057680
Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomasQ81168633
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)214-226
P577publication date2009-10-19
P1433published inOncogeneQ1568657
P1476titleThe Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells
P478volume29

Reverse relations

cites work (P2860)
Q34042332An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells
Q39459026CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
Q39268054CXCL1/GROα increases cell migration and invasion of prostate cancer by decreasing fibulin-1 expression through NF-κB/HDAC1 epigenetic regulation
Q35986081Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.
Q31062741Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607.
Q27671005Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase
Q35777328Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice
Q26750872Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer
Q36232073HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.
Q41708922HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling.
Q35025393Intron retention in the alternatively spliced region of RON results from weak 3' splice site recognition
Q38116308MSP-RON signalling in cancer: pathogenesis and therapeutic potential
Q39631141MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF- B signals in gastric cancer cells
Q92987345MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages
Q37377252MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteur d'Origine Nantais
Q36698670Myeloid-specific expression of Ron receptor kinase promotes prostate tumor growth.
Q49491161Norleual, a hepatocyte growth factor and macrophage stimulating protein dual antagonist, increases pancreatic cancer sensitivity to gemcitabine
Q26798154Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology
Q35146597RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma
Q38543678Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer
Q35053054Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein
Q44605323Ron and its expanding role in tumor carcinogenesis
Q35577352Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia
Q27003295Ron receptor tyrosine kinase signaling as a therapeutic target
Q24303622Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein
Q37847052Targeting tyrosine kinases and autophagy in prostate cancer
Q35190869The Ron receptor promotes prostate tumor growth in the TRAMP mouse model.
Q33783151The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer
Q53672205The potential of CXCL5 as a target for liver cancer - what do we know so far?
Q91673432Therapeutic Considerations for Ron Receptor Expression in Prostate Cancer
Q37166978Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD
Q58777826Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation
Q35100064β-Catenin is required for Ron receptor-induced mammary tumorigenesis

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