The art of healing broken hearts in breast cancer patients: Trastuzumab and heart failure

scientific article

The art of healing broken hearts in breast cancer patients: Trastuzumab and heart failure is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P932PMC publication ID2807779
P698PubMed publication ID20098570

P2093author name stringPawan K Singal
Davinder S Jassal
Jonathan R Walker
P2860cites workRequirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cellsQ24317507
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Untangling the ErbB signalling networkQ27860884
Cardiac dysfunction in the trastuzumab clinical trials experienceQ28204298
Trastuzumab-related cardiotoxicity: calling into question the concept of reversibilityQ28239961
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathyQ28593656
Trastuzumab--mechanism of action and use in clinical practiceQ29615810
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerQ29617440
Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibitionQ33263478
Anthracycline-trastuzumab regimens for HER2/neu-overexpressing breast cancer: current experience and future strategiesQ33334742
Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerability and adverse event data from the NCCTG Phase III Trial N9831.Q33427353
Epidermal growth factor receptors: critical mediators of multiple receptor pathwaysQ33597368
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).Q33730975
The role of radiation therapy for primary breast cancerQ33779190
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalingQ33886341
Overexpression of ErbB2 in cancer and ErbB2-targeting strategiesQ33931164
New strategies for managing metastatic breast cancer.Q33942787
Myocyte survival pathways and cardiomyopathy: implications for trastuzumab cardiotoxicity.Q34173142
Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapyQ34429785
Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2.Q34492647
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancerQ34496969
Estimating the world cancer burden: Globocan 2000.Q34518922
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failureQ34620874
Angiotensin-converting enzyme inhibitor in the treatment of epirubicin-induced dilated cardiomyopathyQ34739645
Adjuvant trastuzumab therapy for HER2-positive breast cancerQ34817097
Essential roles of Her2/erbB2 in cardiac development and functionQ35641803
Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancerQ35792244
Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapyQ36126521
Trastuzumab: a review of its use in the management of HER2-positive metastatic and early-stage breast cancerQ36441450
Delayed contrast enhancement cardiac magnetic resonance imaging in trastuzumab induced cardiomyopathyQ36462641
Herceptin (trastuzumab): adjuvant and neoadjuvant trials.Q36533209
Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and managementQ36828128
Cancer in Canada in 2008Q36972398
Trastuzumab as the lead monoclonal antibody in advanced breast cancer: choosing which patient and whenQ37074153
Sentinel lymphadenectomy in breast cancerQ37084344
Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoringQ37123487
Cardiotoxicity profile of trastuzumabQ37165488
Trastuzumab-induced cardiomyopathy.Q37178421
Carvedilol as a protector against the cardiotoxicity induced by anthracyclines (doxorubicin).Q37379904
Cardiac toxicity with anti-HER-2 therapies: what have we learned so far?Q37471532
FISH detection of HER-2/neu oncogene amplification in early onset breast cancerQ38479141
Treatment with angiotensin-converting-enzyme inhibitor for epirubicin-induced dilated cardiomyopathyQ39467426
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.Q40866492
EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signalingQ41737540
Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial.Q42626922
Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathwaysQ43124366
Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractionsQ43472007
Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trialQ43610373
ErbB2 is essential in the prevention of dilated cardiomyopathy.Q43976647
Anti-oxidants and apoptosis: attenuation of doxorubicin induced cardiomyopathy by carvedilolQ45068575
Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathyQ45175895
Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancerQ45854680
Evaluation of HER-2/neu gene amplification and overexpression: comparison of frequently used assay methods in a molecularly characterized cohort of breast cancer specimens.Q46037818
Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline mediated cardiomyopathyQ46096452
Multicentric, randomized phase III trial of two different adjuvant chemotherapy regimens plus three versus twelve months of trastuzumab in patients with HER2- positive breast cancer (Short-HER Trial; NCT00629278).Q46295115
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.Q53243856
Prediction of pathogenic mutations in patients with early-onset breast cancer by family historyQ57266776
Trastuzumab mediated cardiotoxicity in the setting of adjuvant chemotherapy for breast cancer: a retrospective studyQ57695765
Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapyQ73117839
Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neuQ73174660
A new anti-ErbB2 strategy in the treatment of cancer: prevention of ligand-dependent ErbB2 receptor heterodimerizationQ74693294
Doxorubicin-induced cardiomyopathyQ77323607
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experienceQ80112164
Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatmentQ81419131
Type II chemotherapy-related cardiac dysfunction: time to recognize a new entityQ81698731
Pegylated liposomal doxorubicin and trastuzumab as 1st and 2nd line therapy in her2/neu positive metastatic breast cancer: a multicenter phase II trialQ83209550
P433issue3
P921main subjectheart failureQ181754
trastuzumabQ412616
P304page(s)e62-7
P577publication date2009-01-01
P1433published inExperimental & Clinical CardiologyQ5421099
P1476titleThe art of healing broken hearts in breast cancer patients: Trastuzumab and heart failure
P478volume14

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cites work (P2860)
Q36921775Risk factors for anthracycline-associated cardiotoxicity
Q48344109Trastuzumab resumption after extremely severe cardiotoxicity in metastatic breast cancer patient: a case report
Q35532125Trastuzumab-induced cardiac dysfunction: A 'dual-hit'

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