p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

scientific article

p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.01776
P932PMC publication ID4017649
P698PubMed publication ID24843008

P50authorMichal KrawczykQ78782087
P2093author name stringBeverly M Emerson
P2860cites workChromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL ExpressionQ21092443
Long noncoding RNA as modular scaffold of histone modification complexesQ22065890
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxiaQ24294721
CTCF physically links cohesin to chromatinQ24321344
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasisQ24607308
CTCF: master weaver of the genomeQ24621388
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitryQ24633673
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4aQ24633736
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genomeQ24648552
Specific expression of long noncoding RNAs in the mouse brainQ24648944
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expressionQ24654249
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domainsQ24655087
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiationQ24655701
H19 overexpression in breast adenocarcinoma stromal cells is associated with tumor values and steroid receptor status but independent of p53 and Ki-67 expressionQ24682023
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sitesQ24682593
COX-2 and PGE2-dependent immunomodulation in breast cancerQ27003937
High-resolution profiling of histone methylations in the human genomeQ27860906
Long non-coding RNAs: insights into functionsQ28131764
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammalsQ28131802
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneQ28145754
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusQ28145756
ChIP-seq accurately predicts tissue-specific activity of enhancersQ28235102
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesisQ28240820
Loss of H19 imprinting in esophageal cancerQ28273448
GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancerQ28296081
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatinQ28506981
A long noncoding RNA mediates both activation and repression of immune response genesQ28509769
Genome-wide identification of polycomb-associated RNAs by RIP-seqQ28513635
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)Q28586461
Genes that mediate breast cancer metastasis to lungQ29547479
Tumour-educated macrophages promote tumour progression and metastasisQ29614307
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expressionQ29614326
A unique chromatin signature uncovers early developmental enhancers in humansQ29614327
Widespread transcription at neuronal activity-regulated enhancersQ29614330
Evolution and functions of long noncoding RNAsQ29614331
Long noncoding RNAs: functional surprises from the RNA worldQ29615826
Cyclooxygenases: structural, cellular, and molecular biologyQ29616510
Molecular mechanisms of long noncoding RNAsQ29618027
Non-coding RNAs in human diseaseQ29618039
Cohesin mediates transcriptional insulation by CCCTC-binding factorQ29618130
Cohesins functionally associate with CTCF on mammalian chromosome armsQ29618753
Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancersQ72119659
Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulatorQ72147436
Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic miceQ73693790
Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumorsQ74181079
Establishment and characterization of a human histiocytic lymphoma cell line (U-937)Q29619570
CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.Q30502612
CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wideQ33268598
Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genesQ33866301
Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signalingQ33999059
CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatinQ34021284
Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathwayQ34025186
Chromosomal silencing and localization are mediated by different domains of Xist RNA.Q34108304
Cyclooxygenases and lipoxygenases in cancerQ34224752
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.Q34618411
The cycloxygenase 2 (COX-2) story: it's time to explain, not inflameQ34636574
Long intergenic noncoding RNAs: new links in cancer progressionQ34676547
The functional role of long non-coding RNA in human carcinomasQ34995156
A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locusQ35163141
A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivationQ35297877
Transcriptional regulation of cyclo-oxygenase expression: three pillars of controlQ35557242
H19 expression in hepatic metastases from a range of human carcinomasQ35588750
Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemopreventionQ35864033
Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesisQ36854812
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundaryQ37297042
A wave of nascent transcription on activated human genesQ37385772
Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumorsQ37683666
Long noncoding RNAs and human diseaseQ37873053
CTCF and cohesin: linking gene regulatory elements with their targetsQ38090111
Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failureQ38311997
p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissueQ38443641
NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expressionQ39510292
Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinomaQ39618885
Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cellsQ39886194
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulatorsQ40020777
Cyclooxygenase-2 gene transcription in a macrophage model of inflammationQ40206532
Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cellsQ40553357
TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cellsQ42690408
Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serumQ42806232
Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytesQ43548398
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant programQ46704393
Modulation of NF-kappaB activity by exchange of dimers.Q53860042
p50 Nuclear Factor- B Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor ResistanceQ56942931
Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophagesQ72108169
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)e01776
P577publication date2014-04-29
P1433published ineLifeQ2000008
P1476titlep50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes
P478volume3

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cites work (P2860)
Q58093179A novel testis-specific long noncoding RNA, Tesra, activates the Prss42/Tessp-2 gene during mouse spermatogenesis
Q90397104An Exploratory Gene Expression Study of the Intestinal Mucosa of Patients with Non-Celiac Wheat Sensitivity
Q38848213Biological Response Modifier in Cancer Immunotherapy
Q46308011Catalog of Differentially Expressed Long Non-Coding RNA following Activation of Human and Mouse Innate Immune Response
Q50053910Control of Immune Cell Homeostasis and Function by lncRNAs.
Q38656230Cytokines and Long Noncoding RNAs
Q40413010Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.
Q47657395Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis
Q33601739Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression
Q38729438Emerging roles of lncRNAs in senescence.
Q64230066Emerging roles of long noncoding RNA in chondrogenesis, osteogenesis, and osteoarthritis
Q61449789Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection
Q26772718Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS
Q38763953Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts
Q100946346Expression of NF-κB associated lncRNAs in schizophrenia
Q37720147Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride
Q38732993From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis
Q37237471Functional diversity of long non-coding RNAs in immune regulation
Q35938846Functional elucidation of the non-coding RNAs of Kluyveromyces marxianus in the exponential growth phase
Q38638798Gene regulation in the immune system by long noncoding RNAs.
Q57279765Global identification and characterization of lncRNAs that control inflammation in malignant cholangiocytes
Q61797004Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster
Q39104939Immunobiology of Long Noncoding RNAs.
Q90524396In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models
Q90730345Integrated analysis of long non-coding RNAs and mRNAs associated with peritendinous fibrosis
Q64078558Integrative Analyses of Long Non-coding RNA and mRNA Involved in Piglet Ileum Immune Response to Type C Infection
Q37640216Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
Q39366670LncRNA-mediated regulation of cell signaling in cancer.
Q37390759LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner
Q33608858LncRNAs and immunity: watchdogs for host pathogen interactions.
Q50096190LncRNAs in vascular biology and disease.
Q42378533LncRNAs: key players and novel insights into diabetes mellitus
Q37106356Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage.
Q52880778Long Non-Coding RNAs Regulating Immunity in Insects.
Q90207786Long Non-Coding RNAs and the Innate Immune Response
Q64230361Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease
Q54225670Long Non-Coding RNAs: Novel Players in Regulation of Immune Response Upon Herpesvirus Infection.
Q60959900Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
Q98465782Long Non-coding RNAs in the Regulation of the Immune Response and Trained Immunity
Q56396247Long Non-coding RNAs: Regulators of Viral Infection and the Interferon Antiviral Response
Q92921576Long Noncoding RNA in Myeloid and Lymphoid Cell Differentiation, Polarization and Function
Q46319913Long Noncoding RNAs in Mammalian Development and Diseases
Q28073491Long Noncoding RNAs in Metabolic Syndrome Related Disorders
Q28083390Long Noncoding RNAs: A New Regulatory Code in Metabolic Control
Q48316977Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization.
Q92659707Long non-coding RNA expressed in macrophage co-varies with the inflammatory phenotype during macrophage development and polarization
Q36907367Long non-coding RNA expression profile in minor salivary gland of primary Sjögren's syndrome
Q41921337Long non-coding RNA expression profiles in different severity EV71-infected hand foot and mouth disease patients.
Q39034336Long non-coding RNA: a versatile regulator of the nuclear factor-κB signalling circuit
Q39374107Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses
Q34616243Long non-coding RNAs and control of gene expression in the immune system
Q39454814Long non-coding RNAs as novel players in β cell function and type 1 diabetes
Q64922153Long non-coding RNAs in hematopoietic regulation.
Q36446804Long non-coding RNAs in innate and adaptive immunity
Q28078143Long non-coding RNAs in the regulation of myeloid cells
Q38239035Long non-coding RNAs in the regulation of the immune response
Q63916975Long non-coding RNAs regulating macrophage functions in homeostasis and disease
Q37264066Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression
Q37743331Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes.
Q38585296Long noncoding RNA: Novel links between gene expression and innate immunity
Q92002667Long noncoding RNAs and the regulation of innate immunity and host-virus interactions
Q38769321Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity
Q60957163Long noncoding RNAs as regulators of cancer immunity
Q36422024Long noncoding RNAs in diseases of aging
Q26798082Long noncoding RNAs in innate immunity
Q47144390Long noncoding RNAs: a new regulatory code in osteoarthritis
Q38380213Long noncoding RNAs: a potent source of regulation in immunity and disease
Q26752329Mechanisms of long noncoding RNA function in development and disease
Q47626817Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators
Q55365150Molecular Regulatory Pathways Link Sepsis With Metabolic Syndrome: Non-coding RNA Elements Underlying the Sepsis/Metabolic Cross-Talk.
Q63976761Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis
Q51664715Noncoding RNAs Regulating NF-κB Signaling.
Q38885490Noncoding RNAs in Cancer Immunology.
Q26865593Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Q49715418Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression.
Q89665043Nucleosome destabilization by nuclear non-coding RNAs
Q38827100P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene
Q64105160Potential Implications of Long Noncoding RNAs in Autoimmune Diseases
Q39292842Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions
Q59791552Regulation of Endotoxin Tolerance and Compensatory Anti-inflammatory Response Syndrome by Non-coding RNAs
Q91292216Regulation of gene expression by cis-acting long non-coding RNAs
Q35751343Retracted: Multidrug-Resistance Related Long Non-Coding RNA Expression Profile Analysis of Gastric Cancer
Q38841936Review: Long Noncoding RNAs in the Regulation of Inflammatory Pathways in Rheumatoid Arthritis and Osteoarthritis.
Q92671574Role of lncRNAs in aging and age-related diseases
Q90274839Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Q95280414Sex-specific up-regulation of p50-associated COX-2 extragenic RNA (PACER) lncRNA in periodontitis
Q35673679The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases
Q41478225The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease
Q57492046The Long Non-coding RNA Anticipates Foxp3 Expression in Regulatory T Cells
Q61809078The Opening of Pandora's Box: An Emerging Role of Long Noncoding RNA in Viral Infections
Q43416524The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB.
Q60934501The potential roles of long non-coding RNAs in lipopolysaccharide-induced human peripheral blood mononuclear cells as determined by microarray analysis
Q97072562The role of Long Non-Coding RNAs (lncRNAs) and downstream signaling pathways in Leukemia progression
Q38253795Transcription of inflammatory genes: long noncoding RNA and beyond
Q89835621lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer
Q38274918lncRNA-mediated regulation of the interferon response
Q52620644lncRNAs Regulate Innate Immune Responses and Their Roles in Macrophage Polarization.
Q26775906lncRNAs regulate the innate immune response to viral infection

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