Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensiti

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Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensiti is …
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scholarly articleQ13442814

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P356DOI10.3389/FGENE.2014.00117
P8608Fatcat IDrelease_5giwtrlegfgklmqhe2pmkah6ay
P932PMC publication ID4018528
P698PubMed publication ID24834072
P5875ResearchGate publication ID262383293

P50authorJulia MoralesQ56462679
Jérémie BourdonQ56468080
Anne SiegelQ61090466
P2093author name stringOdile Mulner-Lorillon
Patrick Cormier
Robert Bellé
Didier Flament
Sébastien Laurent
Pauline Gosselin
Adrien Richard
Virginie Glippa
P2860cites workeIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryoQ44369652
BIOCHAM: an environment for modeling biological systems and formalizing experimental knowledgeQ44870332
Signal transduction pathways that contribute to CDK1/cyclin B activation during the first mitotic division in sea urchin embryosQ44900922
Model of cap-dependent translation initiation in sea urchin: a step towards the eukaryotic translation regulation network.Q46039858
Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E.Q46370381
Dephosphorylation of eIF2α is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization.Q53179318
Identification of a new isoform of eEF2 whose phosphorylation is required for completion of cell division in sea urchin embryos.Q53282058
Folding transitions during assembly of the eukaryotic mRNA cap-binding complex.Q54123042
Embryonic-stage-dependent changes in the level of eIF4E-binding proteins during early development of sea urchin embryosQ64212163
eIF4E Association with 4E-BP Decreases Rapidly Following Fertilization in Sea UrchinQ64212166
Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysisQ79815641
Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: comparison with eIF4E-binding proteinQ85028042
Translational homeostasis via the mRNA cap-binding protein, eIF4EQ24320659
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap functionQ24324452
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding ProteinsQ24336014
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4EQ24533512
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4EQ24597361
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismQ24603034
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Q24682697
Phylogenetic analysis of eIF4E-family membersQ24813999
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translationQ27860920
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminusQ28257161
The eIF4E-binding proteins 1 and 2 are negative regulators of cell growthQ28299259
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Regulation of translation initiation by FRAP/mTORQ29620398
A variant mimicking hyperphosphorylated 4E-BP inhibits protein synthesis in a sea urchin cell-free, cap-dependent translation systemQ33424506
Flipping the switch: how a sperm activates the egg at fertilizationQ34656165
Molecular mechanism of scanning and start codon selection in eukaryotesQ35192105
Cap-dependent translation and control of the cell cycleQ35573739
The initiation of development at fertilizationQ37872051
Termination and post-termination events in eukaryotic translationQ37975581
Translational control genes in the sea urchin genomeQ40290317
Cap-dependent and cap-independent translation: operational distinctions and mechanistic interpretationsQ40411916
The mRNA 5' cap-binding protein eIF4E and control of cell growthQ41751015
The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.Q42215323
After fertilization of sea urchin eggs, eIF4G is post-translationally modified and associated with the cap-binding protein eIF4E.Q42608488
eIF4E-binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggsQ43272146
P4510describes a project that usesImageJQ1659584
P304page(s)117
P577publication date2014-05-06
P1433published inFrontiers in GeneticsQ2499875
P1476titleModelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensiti
P478volume5

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cites work (P2860)
Q35952095Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos
Q35600091Marine systems biology
Q50562589Model of the delayed translation of cyclin B maternal mRNA after sea urchin fertilization
Q64212178Translational Control in Echinoderms: The Calm Before the Storm
Q64276738Translational Control of Canonical and Non-Canonical Translation Initiation Factors at the Sea Urchin Egg to Embryo Transition

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