Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model

scientific article

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.109.162610
P932PMC publication ID2812111
P698PubMed publication ID19923441
P5875ResearchGate publication ID38099174

P2093author name stringXin Zhou
Xinxin Ding
Fang Xie
Xiaoliang Zhuo
W Griffith Humphreys
Kerri Kluetzman
Yue-Zhong Shu
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Nicotine neuroprotection against nigrostriatal damage: importance of the animal modelQ36782419
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Molybdenum hydroxylases: biological distribution and substrate-inhibitor specificityQ39704403
Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidineQ42042660
Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgenQ42648574
Targeted disruption of the MHC class II Aa gene in C57BL/6 miceQ42809952
Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranesQ43638211
Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brainQ43764263
Total cotinine in plasma: a stable biomarker for exposure to tobacco smokeQ44156717
Microsomal N-glucuronidation of nicotine and cotinine: human hepatic interindividual, human intertissue, and interspecies hepatic variationQ44217904
Targeted Disruption of the Olfactory Mucosa-SpecificCyp2g1Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects onCyp2a5ExpressionQ44650613
Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxideQ45264840
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.Q46189862
Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymesQ46463084
Nicotine metabolism and urinary elimination in mouse: in vitro and in vivoQ46837480
Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5.Q46950227
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasoneQ48178043
Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal ratsQ48208417
Nicotine is more efficient than cotinine at passing the blood-brain barrier in rats.Q48468409
Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb.Q49045714
Development and evaluation of a candidate reference measurement procedure for the determination of progesterone in human serum using isotope-dilution liquid chromatography/tandem mass spectrometry.Q51786502
Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice.Q51909129
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.Q52275435
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomesQ59153191
Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomesQ68060984
Role of human cytochrome P4502A6 in C-oxidation of nicotineQ71820851
Nicotine metabolism by rat hepatic cytochrome P450sQ72825656
Steroid metabolism by rabbit olfactory-specific P450 2G1Q72871282
Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosaQ73226374
Nicotine metabolism and intake in black and white smokersQ74788995
Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosaQ80367595
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectnicotineQ12144
P304page(s)578-587
P577publication date2009-11-18
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleRole of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model
P478volume332

Reverse relations

cites work (P2860)
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