Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

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Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROBIOLAGING.2012.11.024
P932PMC publication ID4022280
P698PubMed publication ID23273601
P5875ResearchGate publication ID234010269

P2093author name stringJoseph Rogers
Daniel L Gillen
David H Cribbs
Paul D Coleman
Carl W Cotman
Nicole C Berchtold
P2860cites workNeuroligins and neurexins link synaptic function to cognitive diseaseQ22251092
Membrane fusion: grappling with SNARE and SM proteinsQ24633113
Neuropathological stageing of Alzheimer-related changesQ27860862
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusionQ28255534
Ephrin regulation of synapse formation, function and plasticityQ28262811
SNAREs--engines for membrane fusionQ29547230
Spatio-temporal transcriptome of the human brainQ29614572
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's diseaseQ30080016
Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's diseaseQ30494084
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.Q31146509
Hippocampal gene expression patterns underlying the enhancement of memory by running in aged miceQ33927915
Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairmentQ33944349
Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's diseaseQ33984420
A systems level analysis of transcriptional changes in Alzheimer's disease and normal agingQ33985604
Gene regulation and DNA damage in the ageing human brainQ34326236
The aging brain: morphomolecular senescence of cortical circuitsQ34349216
Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteomeQ34441471
Functional alterations in memory networks in early Alzheimer's diseaseQ34565270
Detection of behavioral alterations and learning deficits in mice lacking synaptophysin.Q34977739
Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeysQ35010148
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairmentQ35957965
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray studyQ36164195
Temporal dynamics and genetic control of transcription in the human prefrontal cortexQ36435510
The ageing cortical synapse: hallmarks and implications for cognitive declineQ36668062
Synapses are lost during aging in the primate prefrontal cortexQ36739543
Gene expression changes in the course of normal brain aging are sexually dimorphicQ36926809
The anatomy of memory: an interactive overview of the parahippocampal-hippocampal networkQ37418920
Epileptic seizures in AD patientsQ37532139
Somatostatin, Alzheimer's disease and cognition: an old story coming of age?Q37549147
Should Alzheimer's disease be equated with human brain ageing? A maladaptive interaction between brain evolution and senescenceQ37901814
The neurobiology of Alzheimer disease defined by neuroimagingQ38024255
Fractionating spatial memory with glutamate receptor subunit-knockout miceQ43243509
Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 regionQ43274306
Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity.Q44746570
Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment.Q46452465
Effects of exercise on gene-expression profile in the rat hippocampusQ46810775
Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments.Q47408579
Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampusQ47814812
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmissionQ48144404
Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's diseaseQ48350194
Genome wide profiling of altered gene expression in the neocortex of Alzheimer's diseaseQ48398994
Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging.Q48795076
Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease.Q48824036
Impaired tactile acuity in old age is accompanied by enlarged hand representations in somatosensory cortex.Q48827773
Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex.Q48866108
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.Q48963534
Molecular aging in human prefrontal cortex is selective and continuous throughout adult life.Q49012912
Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: a quantitative ultrastructural studyQ69079998
P433issue6
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1653-1661
P577publication date2012-12-27
P1433published inNeurobiology of AgingQ7002141
P1476titleSynaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease
P478volume34

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