In search of novel drug target sites on estrogen receptors using RNA aptamers

scientific article

In search of novel drug target sites on estrogen receptors using RNA aptamers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/NAT.2013.0474
P932PMC publication ID4026216
P698PubMed publication ID24588102

P50authorAntonis KourtidisQ42663296
Douglas ConklinQ70617435
P2093author name stringHua Shi
Daiying Xu
Vamsee-Krishna Chatakonda
P2860cites workMechanisms of Endocrine Resistance in Breast CancerQ36851417
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Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activityQ38311324
Selection and characterization of an RNA decoy for transcription factor NF-kappa B.Q38327211
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptorQ38346347
Composite RNA aptamers as functional mimics of proteinsQ38437211
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistanceQ40196763
Allosteric modulation of estrogen receptor conformation by different estrogen response elementsQ40795091
Stable expression of the human estrogen receptor in HeLa cells by infection: effect of estrogen on cell proliferation and c-myc expressionQ41682653
Molecular mechanisms of selective estrogen receptor modulator activity in human breast cancer cells: identification of novel nuclear cofactors of antiestrogen-ERα complexes by interaction proteomicsQ43862461
Differential recruitment of nuclear receptor coregulators in ligand-dependent transcriptional repression by estrogen receptor-α.Q51531609
Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding InhibitorsQ57531472
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogensQ73222352
Estrogen and cancerQ87416260
A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complexQ22009369
Mfold web server for nucleic acid folding and hybridization predictionQ24498105
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor bindingQ24554243
A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474Q24564911
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypesQ24647928
Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose LevelsQ24672877
The complete atomic structure of the large ribosomal subunit at 2.4 A resolutionQ27626400
Overexpression, purification, and crystal structure of native ER alpha LBDQ27632980
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical methodQ27650591
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elementsQ27731441
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifenQ27766417
Estrogen and progesterone receptors: from molecular structures to clinical targetsQ28239860
Selective estrogen receptor modulators: an update on recent clinical findingsQ28268883
Peptide antagonists of the human estrogen receptorQ30633677
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and betaQ30815190
Protein-dependent ribozymes report molecular interactions in real time.Q31090005
A resource for large-scale RNA-interference-based screens in mammals.Q33200135
Loss of estrogen receptor 1 enhances cervical cancer invasion.Q33617319
Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Q33780204
Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes.Q33781651
Commandeering a biological pathway using aptamer-derived molecular adaptorsQ33783191
Development of peptide antagonists that target estrogen receptor-cofactor interactionsQ34132677
Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancerQ34133476
Structural basis for nuclear hormone receptor DNA binding.Q34204743
Development of subtype-selective oestrogen receptor-based therapeutics.Q34216817
The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancerQ34311300
Small molecule inhibitors as probes for estrogen and androgen receptor actionQ34575905
Human estrogen receptor-alpha: regulation by synthesis, modification and degradation.Q34712217
A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactionsQ36356454
Derailed estrogen signaling and breast cancer: an authentic couple.Q36589361
A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cellsQ36741592
P4510describes a project that usesImageQuantQ112270642
P433issue3
P304page(s)226-238
P577publication date2014-03-03
P1433published inNucleic Acid TherapeuticsQ19297428
P1476titleIn search of novel drug target sites on estrogen receptors using RNA aptamers
P478volume24

Reverse relations

cites work (P2860)
Q35224117An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.
Q35979128Aptamer-Assisted Detection of the Altered Expression of Estrogen Receptor Alpha in Human Breast Cancer
Q36580076Aptamer-Enabled Manipulation of the Hsp70 Chaperone System Suggests a Novel Strategy for Targeted Ubiquitination
Q38289419DNA aptamer probes for detection of estrogen receptor α positive carcinomas
Q36602448In silico selection of an aptamer to estrogen receptor alpha using computational docking employing estrogen response elements as aptamer-alike molecules.
Q38288965Selection of DNA aptamers for extra cellular domain of human epidermal growth factor receptor 2 to detect HER2 positive carcinomas

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