Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice

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Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1041507037
P356DOI10.1007/S13238-014-0047-Y
P932PMC publication ID4026419
P698PubMed publication ID24756564
P5875ResearchGate publication ID261802477

P50authorDi LuQ59690666
Hongxia DuanQ84425035
P2093author name stringPing Wang
Jing Feng
Xiyun Yan
Xuan Jiang
Tao Tu
Dongling Yang
Lina Song
Zhenzhen Wu
Yongting Luo
Qiqun Zeng
P2860cites workPhosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGFQ24302435
The biology of VEGF and its receptorsQ27860704
The role of CD146 (Mel-CAM) in biology and pathologyQ28142374
Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor familyQ28199597
Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cellsQ28208656
Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerizationQ28259698
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceQ28593600
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Endothelial/pericyte interactionsQ29619802
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerQ29622818
Identification and functional assessment of endothelial P1H12.Q31030449
Structure and function of cell adhesion moleculesQ33606178
Clinical applications of angiogenic growth factors and their inhibitorsQ33784288
Outside-in signaling pathway linked to CD146 engagement in human endothelial cellsQ33921887
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factorQ34249827
MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamilyQ34325680
CD146 expression in human breast cancer cell lines induces phenotypic and functional changes observed in Epithelial to Mesenchymal TransitionQ34405536
Molecular mechanisms of vasculogenesis and embryonic angiogenesisQ34445877
Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient miceQ34787599
CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancerQ35709153
CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancerQ36057178
Retinal angiogenesis in development and diseaseQ36342347
Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS.Q36775309
Targeting angiogenesis: progress with anti-VEGF treatment with large moleculesQ37563976
Targeting the tumour vasculature: insights from physiological angiogenesisQ37767356
CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis.Q39327621
NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction.Q39713250
Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation.Q40205226
Structure of intercellular junctions in the endotheliumQ41720664
Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motifQ44283243
Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skinQ44601468
Critical roles of CD146 in zebrafish vascular developmentQ45174391
Molecular cloning and analysis of the mouse gicerin geneQ46380829
Gicerin/Cd146 is involved in zebrafish cardiovascular development and tumor angiogenesisQ47073368
Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion.Q52544714
Activation of Human Endothelial Cells via S-Endo-1 Antigen (CD146) Stimulates the Tyrosine Phosphorylation of Focal Adhesion Kinase p125FAKQ57039912
Use of the mouse aortic ring assay to study angiogenesisQ58313759
Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras ActivationQ58450934
Lessons From the Adjuvant Bevacizumab Trial on Colon Cancer: What Next?Q61773030
Perivascular Multipotent Progenitor Cells in Human OrgansQ63197018
Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in miceQ73034153
A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growthQ73062447
Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasisQ73424564
Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigrationQ74314946
Generation and characterization of a panel of monoclonal antibodies against distinct epitopes of human CD146Q82261909
Signal transduction by vascular endothelial growth factor receptorsQ84461284
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectendotheliumQ111140
knockout mouseQ1364740
tumor angiogenesisQ110495869
P304page(s)445-456
P577publication date2014-04-24
P1433published inProtein & CellQ26854012
P1476titleImpaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice
P478volume5

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cites work (P2860)
Q41258130Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies - A review.
Q26775947Anti-angiogenic alternatives to VEGF blockade
Q39673391Beneficial roles of melanoma cell adhesion molecule in spinal cord transection recovery in adult zebrafish
Q35146217CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development.
Q41267118CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development
Q92717753CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment
Q51030489CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation.
Q35578962CD146: the unveiling of a pro-angiogenic netrin receptor
Q41099919Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells
Q48512258Chamaejasmine B Induces the Anergy of Vascular Endothelial Cells to VEGFA Pro-angiogenic Signal by Autophagic Regulation of VEGFR2 in Breast Cancer
Q57170632ImmunoPET of CD146 in a Murine Hindlimb Ischemia Model
Q64080436Increased serum levels of soluble CD146 and vascular endothelial growth factor receptor 2 in patients with exudative age-related macular degeneration
Q42691450MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation.
Q38782757Magnetic field contributes to the cellular uptake for effective therapy with magnetofection using plasmid DNA encoding against Mcam in B16F10 melanoma in vivo
Q63915825Netrin Family: Role for Protein Isoforms in Cancer
Q26799750Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?
Q40973878Physical Binding of Endothelial MCAM and Neural Transmembrane Protease Matriptase-Novel Cell Adhesion in Neural Stem cell Vascular Niche
Q35628801Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display
Q33598464Targeting CD146 in combination with vorinostat for the treatment of ovarian cancer cells
Q39038566The multifaceted role of CD146/MCAM in the promotion of melanoma progression

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