The serum protein levels of the tPA-BDNF pathway are implicated in depression and antidepressant treatment

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The serum protein levels of the tPA-BDNF pathway are implicated in depression and antidepressant treatment is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084511768
P356DOI10.1038/TP.2017.43
P932PMC publication ID5416686
P698PubMed publication ID28375203

P2093author name stringY Zhang
C Li
H Jiang
D Zhang
Y Yuan
S Chen
Y Yin
N Lu
Y Yue
X Zhi
P2860cites workMajor Depressive DisorderQ56016676
Fibrinolytic activity in depression and neurosisQ67837905
Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implicationsQ24649095
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Biomarkers in schizophrenia: A focus on blood based diagnostics and theranosticsQ28068871
Establishment of two data mining models of lung cancer screening based on three gene promoter methylations combined with telomere damageQ31135543
Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorderQ34374580
The yin and yang of neurotrophin actionQ34439423
The antidepressive effect of the physical exercise correlates with increased levels of mature BDNF, and proBDNF proteolytic cleavage-related genes, p11 and tPA.Q34627344
Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depressionQ35613219
Temporal and spectral properties of esophageal mucosal blood perfusion: a comparison between normal subjects and nutcracker esophagus patientsQ36100862
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorderQ36800477
Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapiesQ36976169
Toward clinically applicable biomarkers in bipolar disorder: focus on BDNF, inflammatory markers, and endothelial functionQ37588877
Depression and treatment response: dynamic interplay of signaling pathways and altered neural processesQ37634525
Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484).Q38130092
Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disordersQ39107855
Neurotrophins and neuronal plasticityQ40418979
Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicideQ40880250
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorderQ41183343
Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytesQ42752136
Plasma BDNF and tPA are associated with late-onset geriatric depressionQ42985490
Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment.Q43260112
Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus.Q44078826
Upregulation of blood proBDNF and its receptors in major depressionQ44413363
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityQ45108268
Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampusQ47796009
Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediatorQ48067509
Higher serum tropomyosin-related kinase B protein level in major depressionQ48284246
Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depressionQ48373515
Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshockQ48562983
BDNF enhances neuronal growth and synaptic activity in hippocampal cell culturesQ48565222
Decreased serum brain-derived neurotrophic factor levels in major depressed patientsQ48642995
Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampusQ48670912
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)e1079
P577publication date2017-04-04
P1433published inTranslational PsychiatryQ15716636
P1476titleThe serum protein levels of the tPA-BDNF pathway are implicated in depression and antidepressant treatment
P478volume7

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cites work (P2860)
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Q92618435BDNF gene polymorphism and serum level correlate with liver function in patients with hepatitis B-induced cirrhosis
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Q94457797miR-22 and cerebral microbleeds in brainstem and deep area are associated with depression one month after ischemic stroke

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