Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

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Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease is …
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P6179Dimensions Publication ID1042385662
P356DOI10.1186/1471-2164-15-199
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/1471-2164-15-199
P932PMC publication ID4028079
P698PubMed publication ID24628925
P5875ResearchGate publication ID260839098

P50authorPuneet TalwarQ57336794
Sandeep GroverQ83774814
P2093author name stringRitushree Kukreti
Rachna Agarwal
Suman Kushwaha
Meenal Gupta
Yumnam Silla
P2860cites workMultitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinasesQ39265227
Cholesterol and amyloid-β: evidence for a cross-talk between astrocytes and neuronal cellsQ39560441
mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I.Q39872145
Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.Q40089983
Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individualsQ40206193
A potential role for apoptosis in neurodegeneration and Alzheimer's diseaseQ40437117
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseQ22251067
Role of Genes and Environments for Explaining Alzheimer DiseaseQ22253029
Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cellsQ24299546
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptorsQ24308715
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
The Universal Protein Resource (UniProt): an expanding universe of protein informationQ24538737
Genenames.org: the HGNC resources in 2013Q24595108
NCBI GEO: archive for functional genomics data sets--updateQ24595691
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseQ24612662
Genome-wide association study reveals genetic risk underlying Parkinson's diseaseQ24646654
A second generation human haplotype map of over 3.1 million SNPsQ24651939
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriersQ24654145
The human genome browser at UCSCQ24672361
Epidemiology of Alzheimer diseaseQ26865371
A comparative study of cancer proteins in the human protein-protein interaction networkQ27496590
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
A method and server for predicting damaging missense mutationsQ27860835
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene listsQ28131785
Sys-BodyFluid: a systematical database for human body fluid proteome researchQ37202808
Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.Q37497056
Amphiphysin I and regulation of synaptic vesicle endocytosisQ37662707
Evidence for impaired amyloid β clearance in Alzheimer's diseaseQ37690374
Network-based methods for human disease gene predictionQ37901985
Use of next-generation sequencing and other whole-genome strategies to dissect neurological diseaseQ38020089
Computational tools for prioritizing candidate genes: boosting disease gene discoveryQ38023145
Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neuronsQ38325429
Age-related changes in gene expression are accelerated in Alzheimer's diseaseQ38336477
Walking the interactome for prioritization of candidate disease genesQ39140568
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene databaseQ28280965
The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretionQ28344845
A new methodology to associate SNPs with human diseases according to their pathway related contextQ28477617
Systems biology approach reveals genome to phenome correlation in type 2 diabetesQ28484866
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout miceQ28510217
FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression patternQ28565223
CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampusQ28572225
Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cellsQ28577298
PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptorsQ28578985
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionQ28585864
Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neuronsQ28592712
Beyond differential expression: the quest for causal mutations and effector moleculesQ28727736
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's diseaseQ28742427
Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of dataQ28943545
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene databaseQ29417106
Human non-synonymous SNPs: server and surveyQ29547603
Towards a knowledge-based Human Protein AtlasQ29617987
Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory lossQ30420041
Cytoskeletal pathologies of Alzheimer diseaseQ30435267
Meta-analysis of linkage studies for Alzheimer's disease--a web resourceQ30484112
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 miceQ30497102
Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's diseaseQ31117412
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.Q31146509
Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patientsQ32062370
Evaluation of clustering algorithms for protein-protein interaction networksQ33262820
Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation.Q33274604
A computational analysis of protein-protein interaction networks in neurodegenerative diseasesQ33345563
Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathologyQ33345759
Layered functional network analysis of gene expression in human heart failureQ33486544
GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an exampleQ33490113
Gene prioritization in Type 2 Diabetes using domain interactions and network analysisQ33528282
ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.Q33652534
Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampusQ33679171
Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brainsQ33692288
Systems biology analyses of gene expression and genome wide association study data in obstructive sleep apneaQ33759579
Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex diseaseQ40963834
Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteinsQ40977784
Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genesQ41023780
The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's diseaseQ41215942
Integrative bioinformatics analysis of proteins associated with the cardiorenal syndromeQ41217019
Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons.Q41437626
How complete are current yeast and human protein-interaction networks?Q41838577
GeneVenn - A web application for comparing gene lists using Venn diagramsQ41908722
A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a caseQ42567659
Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic riskQ42612701
Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twinsQ42668185
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.Q43197086
Differences in regional and subcellular localization of G(q/11) and RGS4 protein levels in Alzheimer's disease: correlation with muscarinic M1 receptor binding parametersQ44209559
S-linked protein homocysteinylation: identifying targets based on structural, physicochemical and protein-protein interactions of homocysteinylated proteins.Q44778452
Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal deathQ45345438
Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.Q46843633
Blood-based protein biomarkers for diagnosis of Alzheimer diseaseQ47378944
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer diseaseQ47596541
Positional integratomic approach in identification of genomic candidate regions for Parkinson's diseaseQ48135024
Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.Q48199367
APID2NET: unified interactome graphic analyzer.Q48392567
Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Relation to dementia, apolipoprotein E polymorphism, cerebral atrophy, and white matter lesions.Q48787935
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms.Q48846656
Differential regulation of proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) and pp125(FAK) by glutamate and depolarization in rat hippocampus.Q48860782
The role of ABCA1 gene sequence variants on risk of Alzheimer's disease.Q48965077
Normalization of gene expression using SYBR green qPCR: a case for paraoxonase 1 and 2 in Alzheimer's disease brains.Q50518641
Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients.Q51601187
Computing topological parameters of biological networks.Q51900389
Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation.Q52538801
Cerebrospinal fluid apolipoprotein E (apoE) levels in Alzheimer's disease patients are increased at follow up and show a correlation with levels of tau protein.Q53218418
Cerebrospinal fluid apolipoprotein E level is increased in late-onset Alzheimer's disease.Q53324676
Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia.Q53333989
Quantitative assessment of the effect of ABCA1 gene polymorphism on the risk of Alzheimer's disease.Q53334126
Age-dependent decline in the apolipoprotein E level in cerebrospinal fluid from control subjects and its increase in cerebrospinal fluid from patients with Alzheimer's disease.Q53896191
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's diseaseQ56769920
Genetic Analysis: Moving between Linkage and AssociationQ57259233
Risk of Cognitive Impairment or Dementia in Relatives of Patients With Parkinson DiseaseQ57549862
An unbiased evaluation of gene prioritization toolsQ60787745
Lack of Familial Aggregation of Parkinson Disease and Alzheimer DiseaseQ61046067
Measurement of apolipoprotein E (apoE) in cerebrospinal fluidQ73818777
Microarray analysis in Alzheimer's disease and normal agingQ80570828
SCAN: SNP and copy number annotationQ33779644
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOEQ33838241
Prioritization of epilepsy associated candidate genes by convergent analysisQ33842223
Molecular mechanisms of neurodegeneration in Alzheimer's diseaseQ33871297
SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association studyQ33957829
clusterMaker: a multi-algorithm clustering plugin for CytoscapeQ34070756
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Q34123651
Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotypeQ34192190
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individualsQ34305083
A comprehensive network and pathway analysis of candidate genes in major depressive disorderQ34333537
Concerted perturbation observed in a hub network in Alzheimer's diseaseQ34344867
Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.Q34385900
ECRbase: database of evolutionary conserved regions, promoters, and transcription factor binding sites in vertebrate genomesQ34580027
Genetics of Alzheimer's disease: a centennial reviewQ34656812
A pilot study of gene/gene and gene/environment interactions in Alzheimer diseaseQ34723301
Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability.Q34807482
Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal deathQ34976924
NCBI's Database of Genotypes and Phenotypes: dbGaP.Q35057773
Epidemiology of neurodegenerationQ35062651
Alzheimer's disease and Parkinson's diseaseQ35097797
A genome-wide association study of agingQ35343147
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.Q35558526
Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variantsQ35751270
Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI).Q35781558
Alzheimer disease susceptibility loci: evidence for a protein network under natural selectionQ35877845
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer diseaseQ36183810
Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal modelsQ36255584
Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's diseaseQ36283394
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.Q36383616
Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement miceQ36822983
Amphiphysin-1 protein level changes associated with tau-mediated neurodegenerationQ36966655
The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegenerationQ37017266
Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid.Q37155515
Genetic control of human brain transcript expression in Alzheimer diseaseQ37156046
P4510describes a project that usesCytoscapeQ3699942
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)199
P577publication date2014-03-15
P1433published inBMC GenomicsQ15765854
P1476titleGenomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease
P478volume15

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cites work (P2860)
Q41519395A Pilot Proteomic Analysis of Salivary Biomarkers in Autism Spectrum Disorder
Q37087410A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease
Q64068852ApoE4: an emerging therapeutic target for Alzheimer's disease
Q91268052Biomedical informatics applications for precision management of neurodegenerative diseases
Q38622890Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b
Q26750648Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models
Q37530095Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.
Q38583222Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.
Q33734563Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology
Q101051196Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila
Q31030572Integrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy Phenotypes
Q55130393Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease.
Q90499202Machine learning-based identification of genetic interactions from heterogeneous gene expression profiles
Q35648046Medical genetics and genomic medicine in India: current status and opportunities ahead
Q52600144Multifactorial Analysis of a Biomarker Pool for Alzheimer Disease Risk in a North Indian Population.
Q90681796NetControl4BioMed: a pipeline for biomedical data acquisition and analysis of network controllability
Q28552595Network Topology Analysis of Post-Mortem Brain Microarrays Identifies More Alzheimer's Related Genes and MicroRNAs and Points to Novel Routes for Fighting with the Disease
Q64113906Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
Q28596503NeuroRDF: semantic integration of highly curated data to prioritize biomarker candidates in Alzheimer's disease
Q36434711PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome
Q35997979Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.
Q57479938Re-thinking Alzheimer's disease therapeutic targets using gene-based tests
Q61799924Regional protein expression in human Alzheimer's brain correlates with disease severity
Q38792491Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance
Q26748815Review on Graph Clustering and Subgraph Similarity Based Analysis of Neurological Disorders
Q38662596Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease
Q38221025The emergence of proteome-wide technologies: systematic analysis of proteins comes of age.
Q35350853Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain
Q58617327p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation

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