Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.

scientific article

Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.EJPHAR.2009.10.062
P932PMC publication ID2819210
P698PubMed publication ID19887067
P5875ResearchGate publication ID38065075

P50authorXiao-Qing PengQ46736640
Barbara S SlusherQ63959262
Ajit G ThomasQ100427043
P2093author name stringJie Li
Eliot L Gardner
Zheng-Xiong Xi
Charles R Ashby
Krystyna Wozniak
P2860cites workN-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous systemQ28141091
Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDARQ28238132
The neuroactive peptide N-acetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptorQ28242378
Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain - relation to brain concentrationQ28259391
The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophreniaQ28264674
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranesQ28379383
Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanismQ33601673
GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanismQ33606875
Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signalingQ33971691
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbensQ34106031
Neurobiology of relapse to heroin and cocaine seeking: a reviewQ34547387
The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268.Q34725251
Glutamate systems in cocaine addictionQ35690222
The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.Q35827155
Cocaine-induced alterations in dopamine receptor signaling: implications for reinforcement and reinstatementQ36142383
NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognitionQ36521260
Progress in the discovery and development of glutamate carboxypeptidase II inhibitorsQ36934822
Review. Psychological and neural mechanisms of relapseQ37221894
Glutamate and reinstatementQ37373960
Allosteric modulators for mGlu receptorsQ37420479
N-acetylaspartylglutamate (NAAG) inhibits intravenous cocaine self-administration and cocaine-enhanced brain-stimulation reward in rats.Q37438511
Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).Q43608580
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaineQ44186049
Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II InhibitorQ44424814
Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer.Q44902317
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.Q46142561
Enantiospecificity of glutamate carboxypeptidase II inhibitionQ46414038
The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in ratsQ46736593
The regulation of dopamine transmission by metabotropic glutamate receptorsQ48257486
Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens.Q48445359
Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine cravingQ48452964
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in ratsQ48538143
Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeysQ48702113
Modulation of behavioral sensitization to cocaine by NAALADase inhibition.Q51376425
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injuryQ73226156
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cellsQ73456893
Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chainQ83314127
P433issue1-3
P407language of work or nameEnglishQ1860
P304page(s)156-161
P577publication date2009-10-31
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleOral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats
P478volume627