In silico modeling predicts drug sensitivity of patient-derived cancer cells

scientific article

In silico modeling predicts drug sensitivity of patient-derived cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1047655581
P356DOI10.1186/1479-5876-12-128
P932PMC publication ID4030016
P698PubMed publication ID24884660
P5875ResearchGate publication ID262781189

P2093author name stringIla Sri Bharati
Milan Makale
Natsuko Nomura
Pengfei Jiang
Rajesh Mukthavaram
Sandeep C Pingle
Sandra Pastorino
Santosh Kesari
Shireen Vali
Taher Abbasi
Ying Chao
Ashish Agrawal
Ansu Kumar
Shweta Kapoor
Shahabuddin Usmani
Zeba Sultana
P2860cites workDynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapyQ39447688
Development of human tumor cell line panels for use in disease-oriented drug screeningQ39529613
Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: a novel approach for overcoming resistance in anticancer treatmentQ39530855
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.Q39718152
Multiscale agent-based cancer modelingQ40048012
Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model.Q40067799
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cellsQ40321992
An information-intensive approach to the molecular pharmacology of cancer.Q41134023
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.Q41901782
Personalizing medicine: a systems biology perspectiveQ43142778
Identification of molecular subtypes of glioblastoma by gene expression profilingQ48332534
Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory CancersQ50539670
Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis.Q51930607
A mathematical model of glioma growth: the effect of extent of surgical resection.Q52304032
A mathematical model of glioma growth: the effect of chemotherapy on spatio-temporal growth.Q52358855
Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivoQ82738017
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Mutations of the BRAF gene in human cancerQ27860760
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastomaQ28286168
High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical modelsQ28486219
Systematic identification of genomic markers of drug sensitivity in cancer cellsQ29547695
Distinct sets of genetic alterations in melanomaQ29614965
Malignant gliomas in adultsQ29615708
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell linesQ29615823
A computer simulation of progesterone and Cox2 inhibitor treatment for preterm laborQ30977313
In silico cancer modeling: is it ready for prime time?Q35540740
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.Q35564293
Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulusQ36589595
Elastin sequences trigger transient proinflammatory responses by human dermal fibroblastsQ37118751
A colorectal cancer classification system that associates cellular phenotype and responses to therapyQ37175913
Multiscale cancer modelingQ37443767
A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coliQ38364440
P921main subjectin silicoQ192572
P304page(s)128
P577publication date2014-05-21
P1433published inJournal of Translational MedicineQ15716664
P1476titleIn silico modeling predicts drug sensitivity of patient-derived cancer cells
P478volume12

Reverse relations

cites work (P2860)
Q46093038A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
Q96303348A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities
Q92823232A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients
Q92215204Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer
Q47319211Computational modeling in glioblastoma: from the prediction of blood-brain barrier permeability to the simulation of tumor behavior.
Q38719813Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells
Q95319800IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells
Q37392623Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines
Q38968601In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
Q38914605Personalization of cancer treatment using predictive simulation
Q62516274Predicting response to BET inhibitors using computational modeling: A BEAT AML project study
Q30977149S100A4 and its role in metastasis – computational integration of data on biological networks
Q57899349Working towards personalization in medicine: main obstacles to reaching this vision from today's perspective

Search more.