Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders

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Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1004068
P932PMC publication ID4031221
P698PubMed publication ID24853673
P5875ResearchGate publication ID262581974

P50authorJosef MautnerQ87626502
Georg W BornkammQ94069890
P2093author name stringUta Behrends
Dinesh Adhikary
Klaus Witter
Stefanie Linnerbauer
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CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cellsQ39851225
Epitope specificity and clonality of EBV-specific CTLs used to treat posttransplant lymphoproliferative diseaseQ39876410
CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell linesQ40441967
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Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagyQ40649977
Production of genetically modified Epstein-Barr virus-specific cytotoxic T cells for adoptive transfer to patients at high risk of EBV-associated lymphoproliferative diseaseQ41355210
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in manQ41704288
Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognitionQ42066029
Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particlesQ42221268
Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse modelQ42564555
Effective and long-term control of EBV PTLD after transfer of peptide-selected T cellsQ44013424
Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferationQ44618759
Quantitative analysis of EBV-specific CD4/CD8 T cell numbers, absolute CD4/CD8 T cell numbers and EBV load in solid organ transplant recipients with PLTD.Q44968633
Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6.Q45741073
Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.Q45754081
Activity of transplanted CD8+ versus CD4+ cytotoxic T cells against Epstein-Barr virus-immortalized B cell tumors in SCID mice.Q45783101
T cells or active Epstein-Barr virus infection in the development of lymphoproliferative disease in human B cell-injected severe combined immunodeficient miceQ45789448
The history of tumor virologyQ24610004
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1.Q30442797
Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapyQ33289956
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.Q33713932
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsQ33831940
Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disordersQ34121679
Epstein-Barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell linesQ34123922
Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse modelQ34123985
Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and lymphoproliferative disorders after allogeneic stem-cell transplantationQ34312922
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjectsQ34374139
Translating tumor antigens into cancer vaccinesQ34484042
Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trialQ34623991
A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantationQ35012553
Identification of major histocompatibility complex class II-restricted antigens and epitopes of the Epstein-Barr virus by a novel bacterial expression cloning approachQ35139240
EBV-induced human B cell lymphomas in hu-PBL-SCID miceQ35232515
Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer.Q35402927
Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA.Q35829364
The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivatorsQ36079854
Epstein Barr virus-associated tumours: an update for the attention of the working pathologistQ36172481
Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins.Q36228567
Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid miceQ36365868
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectlymphoproliferative disordersQ4165484
P304page(s)e1004068
P577publication date2014-05-22
P1433published inPLOS PathogensQ283209
P1476titleVirus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders
P478volume10

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cites work (P2860)
Q26782845Adoptive T-Cell Immunotherapy
Q91142437Defective Epstein-Barr virus in chronic active infection and haematological malignancy
Q55057118Emergence of CD4+ and CD8+ Polyfunctional T Cell Responses Against Immunodominant Lytic and Latent EBV Antigens in Children With Primary EBV Infection.
Q54266087Human γ-Herpesvirus Infection, Tumorigenesis, and Immune Control in Mice with Reconstituted Human Immune System Components.
Q92151588Immune Control and Vaccination against the Epstein-Barr Virus in Humanized Mice
Q38587362Immune control of oncogenic γ-herpesviruses
Q60306812Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice
Q47195330Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses
Q89587166Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses

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