Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood

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Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...997639V
P356DOI10.1371/JOURNAL.PONE.0097639
P932PMC publication ID4032260
P698PubMed publication ID24858547
P5875ResearchGate publication ID262609311

P50authorArjen J BoenderQ57335887
Roger A H AdanQ88778976
Mieneke C M LuijendijkQ124393079
P2093author name stringKeith M Garner
Margriet A van Gestel
Veronne A J de Vrind
P2860cites workAdeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificityQ24529161
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virionsQ24531466
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectorsQ24538483
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectorsQ24682739
Leptin receptor signaling in midbrain dopamine neurons regulates feedingQ28566114
Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat.Q33960090
Identification of PDGFR as a receptor for AAV-5 transductionQ34264144
AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification methodQ34330377
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteinsQ34330389
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.Q34486856
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infectionQ34486863
Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injectionQ34770058
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6Q35024289
A potential role of distinctively delayed blood clearance of recombinant adeno-associated virus serotype 9 in robust cardiac transductionQ35086706
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9Q35101411
Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectorsQ36509889
Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brainQ37398172
Intracellular viral processing, not single-stranded DNA accumulation, is crucial for recombinant adeno-associated virus transductionQ37682933
Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned ratsQ38348237
Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificityQ39686097
AAV transcytosis through barrier epithelia and endotheliumQ40337905
Analysis of the interaction between adeno-associated virus and heparan sulfate using atomic force microscopyQ40542065
Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection.Q40726384
Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transferQ40819170
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal systemQ41340219
Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous systemQ42012887
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balanceQ43437900
Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate.Q43510516
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous systemQ45007196
Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistributionQ45386068
Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectorsQ45417215
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vectorQ45769447
Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.Q45868778
Blood clearance rates of adenovirus type 5 in miceQ45871684
The ventromedial nucleus of the hypothalamus and the hormonal arousal of sexual behaviors in the female ratQ48315185
Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamusQ48345545
Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectorsQ48427069
Context fear learning specifically activates distinct populations of neurons in amygdala and hypothalamusQ48863650
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e97639
P577publication date2014-05-23
P1433published inPLOS OneQ564954
P1476titleRecombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood
P478volume9

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cites work (P2860)
Q48128479Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex.
Q36249487Bulk regional viral injection in neonatal mice enables structural and functional interrogation of defined neuronal populations throughout targeted brain areas
Q26825131Gene delivery strategies to promote spinal cord repair
Q94474209Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

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