Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin

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Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin is …
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scholarly articleQ13442814

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P356DOI10.1124/MOL.107.042853
P932PMC publication ID2822873
P698PubMed publication ID18381565
P5875ResearchGate publication ID5470264

P50authorChutima SrimaroengQ59682064
Douglas H SweetQ64658376
P2093author name stringAdam L Vanwert
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The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3.Q35699239
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Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.Q40214433
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Transport of levofloxacin in a kidney epithelial cell line, LLC-PK1: interaction with organic cation transporters in apical and basolateral membranes.Q41220992
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Pharmacokinetics of ciprofloxacin. 1st communication: absorption, concentrations in plasma, metabolism and excretion after a single administration of [14C]ciprofloxacin in albino rats and rhesus monkeysQ43483696
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.Q43993855
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradientQ44253313
Penetration of ciprofloxacin into human cerebrospinal fluid in patients with inflamed and non-inflamed meningesQ44667412
Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibitionQ44792818
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).Q46249191
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transportersQ46592194
Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubulesQ46774647
Transepithelial transport of levofloxacin in the isolated perfused rat kidney.Q50513045
P433issue1
P304page(s)122-131
P577publication date2008-04-01
P1433published inMolecular PharmacologyQ1943386
P1476titleOrganic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
P478volume74

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