TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus

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TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...512087D
P356DOI10.1371/JOURNAL.PONE.0012087
P932PMC publication ID2919413
P698PubMed publication ID20711470
P5875ResearchGate publication ID45651374

P50authorNathalie BastienQ69032280
Renée N DouvilleQ97095511
Kent T HayGlassQ56562719
Yan LiQ69032212
Stuart E TurveyQ45358108
P2093author name stringAaron F Hirschfeld
Allan B Becker
Anita L Kozyrskyj
Yuriy Lissitsyn
Rachel E Victor
Joel Liem
Mehtab Sekhon
P2860cites workTolls and beyond--many roads to vaccine immunityQ80219397
A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish childrenQ80543287
TLR4 and MyD88 control protection and pulmonary granulocytic recruitment in a murine intranasal RSV immunization and challenge modelQ82627959
Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphismQ95787611
Common human Toll-like receptor 4 polymorphisms--role in susceptibility to respiratory syncytial virus infection and functional immunological relevanceQ45404884
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus diseaseQ45640302
The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virusQ45658652
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virusQ45739890
The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The GambiaQ47310260
Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole bloodQ47636557
Suppression of pattern-recognition receptor TLR4 sensing does not alter lung responses to pneumovirus infection.Q47643044
Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings.Q51644400
Quantification of human chemokine production in TLR-stimulated and antigen-specific recall responses.Q53467474
Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infectionQ57769012
TLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humansQ24678506
Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infectionQ28307055
MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virusQ28593715
Toll-like receptor control of the adaptive immune responsesQ29547305
Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeuticsQ31047884
Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infectionQ33591425
Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virusQ33848810
Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation clusterQ34693464
Predicting disease using genomicsQ35784521
LPS, TLR4 and infectious disease diversity.Q35988748
Summary of recommendations from the Canadian Asthma Consensus guidelines, 2003.Q36255673
Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infectionsQ36431168
What are we learning from genetic cohort studies?Q36518429
Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.Q37051620
Functional consequences of toll-like receptor 4 polymorphismsQ37071610
Ultrasensitive ELISA for measurement of human cytokine responses in primary cultureQ37210902
Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitisQ37213863
The pharmacogenetics of asthma treatmentQ37343578
TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated diseaseQ37364154
The role of Toll-like receptors in regulating the immune response against respiratory syncytial virusQ37685176
Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young childrenQ38430750
A novel study design to investigate the early-life origins of asthma in children (SAGE study).Q39883686
TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharideQ40117878
TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy.Q43454514
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectimmune responsivenessQ106892710
P304page(s)e12087
P577publication date2010-08-10
P1433published inPLOS OneQ564954
P1476titleTLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus
P478volume5

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cites work (P2860)
Q28073647Association between Toll-Like Receptor 4 Polymorphisms and Systemic Lupus Erythematosus Susceptibility: A Meta-Analysis
Q38366594Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: A Systematic Review and Meta-analysis
Q58327854Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection
Q33603235Comparison of the Expression Changes after Botulinum Toxin Type A and Minocycline Administration in Lipopolysaccharide-Stimulated Rat Microglial and Astroglial Cultures
Q42705186Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness
Q90265096Expression of Human Endogenous Retrovirus-K in Spinal and Bulbar Muscular Atrophy
Q30577527Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients
Q41980154Genetic Diversity of Toll-Like Receptors and Immunity to M. leprae Infection
Q44803336Genetic association of G896A polymorphism of TLR4 gene in leprosy through family-based and case-control study designs
Q38003324Genetics and genomics in pediatric septic shock
Q38163544Host-Viral Interactions: Role of Pattern Recognition Receptors (PRRs) in Human Pneumovirus Infections
Q29048404House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population
Q34163497Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants
Q38098094Respiratory syncytial virus--a comprehensive review
Q54187899Role of TLR4 C>1196T (Thr399Ile) and TLR4 A>896G (Asp299Gly) polymorphisms in a North Indian population with asthma: a case-control study.
Q45358034Role of human TLR4 in respiratory syncytial virus-induced NF-κB activation, viral entry and replication
Q40522232The innate immune response to RSV: Advances in our understanding of critical viral and host factors.
Q27011872The innate immune system of the perinatal lung and responses to respiratory syncytial virus infection
Q50738461The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms.
Q58797369Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children
Q37439961Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis
Q39983452Vitamin D [1,25(OH)2D3] Differentially Regulates Human Innate Cytokine Responses to Bacterial versus Viral Pattern Recognition Receptor Stimuli

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