Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies

scientific article

Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID2823273
P698PubMed publication ID20191935

P50authorDonald M. AndersonQ88717534
P2093author name stringThomas Roth
Christopher Lines
Duane Snavely
Kristel Vandormael
Paulette Ceesay
P2860cites workEstradiol and testosterone modulate the anesthetic action of the GABA-A agonist THIP, but not of the neurosteroid 3alpha,5beta-pregnanolone in the rat.Q44699583
Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep.Q45987247
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Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratoryQ48412641
The effect of gender on autonomic and respiratory responses during sleep among both young and middle-aged subjectsQ48457573
Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trialQ48458311
Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomniaQ48461687
The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomniaQ48466641
Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomniaQ48472265
Sex differences in insomnia: a meta-analysisQ48514727
Sleep of aging women and men: back to basicsQ48514870
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Chronotype and sex effects on sleep architecture and quantitative sleep EEG in healthy young adultsQ48537874
The effects of age and gender on sleep EEG power spectral density in the middle years of life (ages 20-60 years old).Q48694594
Gender differences in irritable bowel syndromeQ78439568
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Tolerability, pharmacokinetics and night-time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjectsQ33156940
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Gender differences in drug responsesQ33264752
Central nervous system side effects associated with zolpidem treatmentQ33842608
Insomnia: definition, prevalence, etiology, and consequencesQ34006700
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Treating insomnia: Current and investigational pharmacological approachesQ34552286
Getting excited about GABA and sex differences in the brainQ34710241
Gender differences in drug effects: implications for anesthesiologistsQ35089206
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Gaboxadol--a new awakening in sleepQ36348054
Effect of gaboxadol on sleep in adult and elderly patients with primary insomnia: results from two randomized, placebo-controlled, 30-night polysomnography studiesQ36948422
Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy modelQ37255508
The measurement of disability.Q41219166
Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomniaQ44679941
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprimary insomniaQ2110202
P304page(s)30-39
P577publication date2010-02-01
P1433published inThe Journal of Clinical Sleep MedicineQ15766748
P1476titleEffect of gaboxadol on patient-reported measures of sleep and waking function in patients with Primary Insomnia: results from two randomized, controlled, 3-month studies
P478volume6

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cites work (P2860)
Q36675803A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors
Q31171354Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data
Q37319964Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats
Q35311652EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women
Q37349496Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome
Q34238302Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects
Q36608004Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness
Q28264334GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons
Q28272266The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

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