Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel

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Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1084130732
P356DOI10.1038/S41598-017-00606-W
P932PMC publication ID5428782
P698PubMed publication ID28356599

P2093author name stringSarai Palanca Suela
Rafael Botella Estrada
Rosa Ballester Sánchez
Blanca de Unamuno Bustos
Begoña Escutia Muñoz
Eduardo Nagore Enguídanos
Gema Pérez Simó
Inmaculada de Juan Jimenez
Margarita Llavador Ros
Mercedes Rodríguez Serna
Rosa Murria Estal
Victor Alegre de Miquel
P2860cites workA landscape of driver mutations in melanomaQ24603357
Mutational heterogeneity in cancer and the search for new cancer-associated genesQ24606956
Exome sequencing identifies recurrent somatic RAC1 mutations in melanomaQ24607661
Melanoma genome sequencing reveals frequent PREX2 mutationsQ24610463
Melanoma: from mutations to medicineQ27024061
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.Q27851483
NRAS mutation status is an independent prognostic factor in metastatic melanomaQ27851695
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAFQ27853045
Distinct sets of genetic alterations in melanomaQ29614965
Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumorQ33510817
Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanomaQ53777162
Telomerase reverse transcriptase promoter mutations in primary cutaneous melanomaQ54374929
Sensitivity and specificity of single-nucleotide polymorphism scanning by high-resolution melting analysis.Q54706020
Defining fast-growing melanomasQ57664769
A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevanceQ33875566
Field guide to next‐generation DNA sequencersQ33904607
Genomic Classification of Cutaneous MelanomaQ34670776
Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes.Q34786717
Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanomaQ34898560
Routine use of the Ion Torrent AmpliSeq™ Cancer Hotspot Panel for identification of clinically actionable somatic mutationsQ35066201
Exome sequencing identifies GRIN2A as frequently mutated in melanomaQ35179796
Comprehensive Molecular Profiling of Archival Bone Marrow Trephines Using a Commercially Available Leukemia Panel and Semiconductor-Based Targeted ResequencingQ35722733
Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylaseQ36071877
RAC1 P29S regulates PD-L1 expression in melanoma.Q36362336
Resistance to BRAF-targeted therapy in melanomaQ38071800
Clinical actionability enhanced through deep targeted sequencing of solid tumorsQ41519437
Panel sequencing melanomasQ41602739
TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation.Q42456732
Mutations in ERBB4 may have a minor role in melanoma pathogenesisQ45799899
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpersonalized medicineQ2072214
P304page(s)495
P577publication date2017-03-29
P1433published inScientific ReportsQ2261792
P1476titleTowards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel
P478volume7

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cites work (P2860)
Q54996932A Next-Generation Sequencing Primer-How Does It Work and What Can It Do?
Q89707410A Rare BRAF V600E mutation detected by Next Generation Sequencing in a superficial spreading melanoma: case report and potential diagnostic implications
Q92819972Cancer Panel Assay for Precision Oncology Clinic: Results from a 1-Year Study
Q101121128Circulating tumor DNA (ctDNA) detection is associated with shorter progression-free survival in advanced melanoma patients
Q89171764Comparison of targeted next generation sequencing (NGS) versus isolated BRAF V600E analysis in patients with metastatic melanoma
Q49617718Comprehensive Next-Generation Sequencing Analysis is Recommended for the Management of Patients With Melanoma
Q46742817Intratumor and Intertumor Heterogeneity in Melanoma
Q92909854Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach
Q98771864Non-BRAF Mutant Melanoma: Molecular Features and Therapeutical Implications
Q92240577Plasticity of Drug-Naïve and Vemurafenib- or Trametinib-Resistant Melanoma Cells in Execution of Differentiation/Pigmentation Program
Q38617527Somatic mutation analysis in melanoma using targeted next generation sequencing
Q92571426Targetable driver mutations in multicentric reticulohistiocytosis
Q64055352Targeting the ERK Signaling Pathway in Melanoma
Q90611117The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas
Q64972523The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic.
Q92431785Whole transcriptome analysis reveals correlation of long noncoding RNA ZEB1-AS1 with invasive profile in melanoma

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