Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices

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Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices is …
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scholarly articleQ13442814

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P819ADS bibcode1990PNAS...87.5359B
P356DOI10.1073/PNAS.87.14.5359
P932PMC publication ID54323
P698PubMed publication ID2371276
P5875ResearchGate publication ID20785367

P2093author name stringC F Stevens
J M Bekkers
G B Richerson
P2860cites workA thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous systemQ69729009
Spontaneous miniature synaptic potentials in hippocampal neuronsQ40265688
NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampusQ43517211
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.Q45964323
Quantal analysis of excitatory postsynaptic potentials induced in hippocampal neurons by activation of granule cellsQ46610453
A simple method to estimate the true diameter of synaptic vesiclesQ48661812
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acidQ48898368
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)5359-5362
P577publication date1990-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOrigin of variability in quantal size in cultured hippocampal neurons and hippocampal slices
P478volume87

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cites work (P2860)
Q28817259A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.
Q42597514A dynamic corral model of receptor trafficking at a synapse
Q73133078A genetically encoded ratiometric indicator for chloride: capturing chloride transients in cultured hippocampal neurons
Q42536302A mathematical description of miniature postsynaptic current generation at central nervous system synapses
Q36274714A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors
Q73144686A new analytical method of studying post-synaptic currents
Q35017546A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses.
Q48487235A reluctant gating mode of glycine receptor channels determines the time course of inhibitory miniature synaptic events in zebrafish hindbrain neurons.
Q39095856A single packet of transmitter does not saturate postsynaptic glutamate receptors
Q24655420Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
Q42001336Accounting for the shapes and size distributions of miniature endplate currents
Q74005804Activity coregulates quantal AMPA and NMDA currents at neocortical synapses
Q44475245Activity-dependent modulation of the rate at which synaptic vesicles become available to undergo exocytosis
Q28264163Activity-dependent scaling of quantal amplitude in neocortical neurons
Q37200970Adenosine decreases neurotransmitter release at central synapses
Q71359135Amplitude and time course of evoked and spontaneous synaptic currents in rat submandibular ganglion cells
Q35851627An evaluation of causes for unreliability of synaptic transmission
Q40174445Analysis and implications of equivalent uniform approximations of nonuniform unitary synaptic systems
Q52255021Analysis of EPSCs and IPSCs carrying rhythmic, locomotor-related information in the isolated spinal cord of the neonatal rat.
Q70985154Analysis of synaptic transmission at single identified boutons on rat spinal neurons in culture
Q46816963Are some minis multiquantal?
Q47885548Attractor reliability reveals deterministic structure in neuronal spike trains
Q33852648Augmentation is a potentiation of the exocytotic process
Q73184388Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging
Q37021437Bi-directional modulation of fast inhibitory synaptic transmission by leptin
Q38218087Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models
Q41691442Ca(2+)-permeable AMPA receptors and spontaneous presynaptic transmitter release at developing excitatory spinal synapses.
Q34171564Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo
Q61813775Chain Modeling of Molecular Communications for Body Area Network
Q48942956Characterization of functional GABAergic synapses formed between rat hypothalamic neurons and pituitary intermediate lobe cells in coculture: Ca2+ dependence of spontaneous IPSCs
Q46429866Characterization of spontaneous excitatory synaptic currents in salamander retinal ganglion cells
Q44728721Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses.
Q33906727Cone photoreceptors respond to their own glutamate release in the tiger salamander
Q34168894Constitutive secretion of exogenous neurotransmitter by nonneuronal cells: implications for neuronal secretion
Q58553974Coupling the Structural and Functional Assembly of Synaptic Release Sites
Q47285061D2-Like dopamine autoreceptor activation reduces quantal size in PC12 cells.
Q52303334Dendritic morphology and its effects on the amplitude and rise-time of synaptic signals in hippocampal CA3 pyramidal cells.
Q34140618Detecting and estimating signals over noisy and unreliable synapses: information-theoretic analysis.
Q37420779Determining the neurotransmitter concentration profile at active synapses
Q48618394Differences in synaptic GABA(A) receptor number underlie variation in GABA mini amplitude.
Q41665914Differences in uniquantal amplitude between sites reduce uniquantal variance when few release sites are active
Q50542040Different correlations among physiological and morphological properties at single glutamatergic synapses in the rat hippocampus and the cerebellum
Q36385823Discharge of the readily releasable pool with action potentials at hippocampal synapses
Q46510786Distinct Ca2+ channels mediate transmitter release at excitatory synapses displaying different dynamic properties in rat neocortex
Q40261587Distinct Quantal Features of AMPA and NMDA Synaptic Currents in Hippocampal Neurons: Implication of Glutamate Spillover and Receptor Saturation
Q46202620Distinctive quantal properties of neurotransmission at excitatory and inhibitory autapses revealed using variance-mean analysis
Q34718048Diversification of synaptic strength: presynaptic elements
Q41719490Diversity of structure and function at mammalian central synapses
Q91629434Drug testing complementary metal-oxide-semiconductor chip reveals drug modulation of transmitter release for potential therapeutic applications
Q33628855Dual coding with STDP in a spiking recurrent neural network model of the hippocampus
Q33245429Dynamical basis of irregular spiking in NMDA-driven prefrontal cortex neurons
Q34981497Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses
Q45240133Dynamics of excitatory synaptic components in sustained firing at low rates
Q34480701Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures
Q47415891Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction
Q41874228Effects of variance in mini amplitude on stimulus-evoked release: a comparison of two models
Q30492449Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.
Q42410780Enhancement of the endosomal endocytic pathway increases quantal size
Q37588622Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture
Q40874481Excitatory inputs to spiny cells in layers 4 and 6 of cat striate cortex
Q49182818Excitatory synaptic connections onto rat hippocampal inhibitory cells may involve a single transmitter release site.
Q48727557Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in rat hippocampus in vitro
Q91666455Extracting quantal properties of transmission at central synapses
Q43601419Extrasynaptic release of dopamine in a retinal neuron: activity dependence and transmitter modulation
Q44021759Facilitation at single synapses probed with optical quantal analysis
Q41674119Fast excitatory synaptic transmission mediated by nicotinic acetylcholine receptors in Drosophila neurons.
Q33361568Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling
Q47887884Fast propagation of firing rates through layered networks of noisy neurons.
Q43921772Focal stimulation of single GABAergic presynaptic boutons on the rat hippocampal neuron
Q37891665From the stochasticity of molecular processes to the variability of synaptic transmission
Q43850108Giant miniature EPSCs at the hippocampal mossy fiber to CA3 pyramidal cell synapse are monoquantal
Q44300269Glycinergic mIPSCs in mouse and rat brainstem auditory nuclei: modulation by ruthenium red and the role of calcium stores
Q48667600Heterogeneity of functional synaptic parameters among single release sites
Q42450397Heterogeneity of postsynaptic receptor occupancy fluctuations among glycinergic inhibitory synapses in the zebrafish hindbrain
Q46813346Hippocampal pyramidal cells excite inhibitory neurons through a single release site
Q37152634Homeostatic regulation of spontaneous and evoked synaptic transmission in two steps
Q44919573How retinal ganglion cells prevent synaptic noise from reaching the spike output
Q31962111IPF, a vesicular uptake inhibitory protein factor, can reduce the Ca(2+)-dependent, evoked release of glutamate, GABA and serotonin
Q41712683Identification of a novel process limiting the rate of synaptic vesicle cycling at hippocampal synapses
Q30547556Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.
Q51642734Implication of frequenin in the facilitation of transmitter release in Drosophila.
Q48130904Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice
Q34148339Independent sources of quantal variability at single glutamatergic synapses.
Q37325648Indistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine
Q60238529Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells
Q50495483Inhibitory transmission mediated by asynchronous transmitter release.
Q41644409Input synchrony and the irregular firing of cortical neurons
Q46095893Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells
Q35111472Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.
Q42639138Intrinsic noise in cultured hippocampal neurons: experiment and modeling.
Q43581690Kainate receptors regulate unitary IPSCs elicited in pyramidal cells by fast-spiking interneurons in the neocortex.
Q33475454Laser-evoked synaptic transmission in cultured hippocampal neurons expressing channelrhodopsin-2 delivered by adeno-associated virus
Q37068382Learning-related synaptic plasticity: LTP and LTD
Q46309730Long-term depression properties in a simple system
Q45937500Long-term potentiation is associated with increases in quantal content and quantal amplitude
Q48916398Maintenance is presynaptic
Q36619608Maturation of Schaffer collateral synapses generates a phenotype of unreliable basal evoked release and very reliable facilitated release
Q48067004Mechanisms of Neuronal Silencing After Cortical Spreading Depression.
Q42863305Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract
Q34465317Mechanisms shaping fast excitatory postsynaptic currents in the central nervous system
Q48600689Metabotropic glutamate receptor enhancement of spontaneous IPSCs in neocortical interneurons
Q47699232Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons
Q48558577Miniature excitatory postsynaptic potentials in embryonic motoneurons grown in slice cultures of spinal cord, dorsal root ganglia and skeletal muscle
Q44485254Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing
Q31874987Modulation of spontaneous quantal release of neurotransmitters in the hippocampus.
Q44251925Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture.
Q48633611Morphofunctional evidence for mature synaptic contacts on the Mauthner cell of 52-hour-old zebrafish larvae.
Q49951069Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus
Q51542408NMDA and non-NMDA receptors are co-localized at excitatory synapses of rat hypoglossal motoneurons.
Q48450420Noise and coupling affect signal detection and bursting in a simulated physiological neural network
Q37102165Noise in the nervous system
Q57985782Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites
Q35763185Nonsaturation of AMPA and NMDA receptors at hippocampal synapses
Q46843644Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus.
Q40742564Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice
Q30552422Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI).
Q41103285Paired recordings from neurones
Q40048338Paired whole cell recordings in organotypic hippocampal slices
Q93046884Parsing Out the Variability of Transmission at Central Synapses Using Optical Quantal Analysis
Q44889380Plastic elimination of functional glutamate release sites by depolarization.
Q48550612Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
Q35172807Presynaptic control of quantal size: kinetic mechanisms and implications for synaptic transmission and plasticity
Q43937868Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord
Q46155606Presynaptic mechanism for long-term potentiation in the hippocampus
Q34468504Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size.
Q46575284Presynaptic regulation of quantal size by the vesicular glutamate transporter VGLUT1.
Q42540862Probabilistic secretion of quanta: spontaneous release at active zones of varicosities, boutons, and endplates
Q64290872Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
Q44872432Properties of quantal transmission at CA1 synapses
Q59080676Properties of synaptic transmission at single hippocampal synaptic boutons
Q34807735Protein quantification at the single vesicle level reveals that a subset of synaptic vesicle proteins are trafficked with high precision
Q48269936Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons
Q40587628Quantal analysis of excitatory postsynaptic currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse.
Q48766503Quantal analysis of excitatory synaptic action and depression in hippocampal slices
Q40587636Quantal analysis of the synaptic excitation of CA1 hippocampal pyramidal cells.
Q28360618Quantal components of the excitatory postsynaptic currents at a rat central auditory synapse
Q72673164Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus
Q33957012Quantal currents at single-site central synapses
Q28249163Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks
Q41084779Quantal parameters of ?minimal? excitatory postsynaptic potentials in guinea pig hippocampal slices: binomial approach
Q46350083Quantal properties of spontaneous EPSCs in neurones of the guinea-pig dorsal lateral geniculate nucleus.
Q37367354Quantal release at a neuronal nicotinic synapse from rat adrenal gland
Q33925886Quantal release of serotonin.
Q40587671Quantal secretion from single visualized synaptic varicosities of sympathetic nerve terminals.
Q44228527Quantal size and variation determined by vesicle size in normal and mutant Drosophila glutamatergic synapses.
Q59021187Quantal synaptic transmission?
Q28356242Quantal variability at glutamatergic synapses in area CA1 of the rat neonatal hippocampus
Q28834241Quantifying Repetitive Transmission at Chemical Synapses: A Generative-Model Approach
Q52719093Rapid active zone remodeling during synaptic plasticity.
Q48716861Rapid kinetics and inward rectification of miniature EPSCs in layer I neurons of rat neocortex
Q46691346Rapid vesicular release, quantal variability, and spillover contribute to the precision and reliability of transmission at a glomerular synapse.
Q51402297Rate of quantal excitation to a retinal ganglion cell evoked by sensory input.
Q41094368Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin
Q48618441Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus.
Q40778431Recycling and refilling of transmitter quanta at the frog neuromuscular junction
Q33863462Regulation of quantal size by presynaptic mechanisms
Q42055101Reliable evaluation of the quantal determinants of synaptic efficacy using Bayesian analysis
Q48094575Restrictions on inhibitory circuits contribute to limited recruitment of fast inhibition in rat neocortical pyramidal cells
Q42946194SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission
Q41103289Saturation of postsynaptic receptors at central synapses?
Q44566046Secretory vesicles membrane area is regulated in tandem with quantal size in chromaffin cells.
Q48242602Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
Q36321911Sequential exocytosis of insulin granules is associated with redistribution of SNAP25
Q41817982Serotonin modulates the excitatory synaptic transmission in the dentate granule cells
Q51636768Shared and private variability in the auditory cortex.
Q28480594Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer
Q30468583Short-term synaptic plasticity regulates the level of olivocochlear inhibition to auditory hair cells
Q48362220Signalling at the synapse: regulation of the post-synaptic response to quantal transmitter release
Q43005920Solutions for transients in arbitrarily branching cables: III. Voltage clamp problems
Q51410871Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations.
Q71323350Spontaneous and uniquantal-evoked endplate currents in normal frogs are indistinguishable
Q48942402Sr2+ and quantal events at excitatory synapses between mouse hippocampal neurons in culture
Q52171875Stable Hebbian learning from spike timing-dependent plasticity.
Q34018327Statistical analysis of synaptic transmission: model discrimination and confidence limits
Q34018363Statistical models of synaptic transmission evaluated using the expectation-maximization algorithm
Q44624677Stochastic fluctuations of the quantal EPSC amplitude in computer simulated excitatory synapses of hippocampus
Q97884807Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review
Q35625601Structural contributions to short-term synaptic plasticity
Q73348006Switching off and on of synaptic sites at aplysia sensorimotor synapses
Q28353555Synapse-specific contribution of the variation of transmitter concentration to the decay of inhibitory postsynaptic currents
Q34971107Synapse-to-synapse variation in mean synaptic vesicle size and its relationship with synaptic morphology and function.
Q35993627Synaptic NMDA receptors mediate hypoxic excitotoxic death
Q50662675Synaptic heterogeneity between mouse paracapsular intercalated neurons of the amygdala.
Q36527660Synaptic input statistics tune the variability and reproducibility of neuronal responses
Q52152097Synaptic unreliability facilitates information transmission in balanced cortical populations.
Q34286724Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume
Q34485356Synaptic vesicle populations in saccular hair cells reconstructed by electron tomography
Q34769128Syntaxin requirement for Ca2+-triggered exocytosis in neurons and endocrine cells demonstrated with an engineered neurotoxin
Q73176563Target-specific factors regulate the formation of glutamatergic transmitter release sites in cultured neocortical neurons
Q24559973Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells
Q34170155Testing the fit of a quantal model of neurotransmission
Q90253180The Transmembrane Domain of Synaptobrevin Influences Neurotransmitter Flux through Synaptic Fusion Pores
Q34354343The amplitude distribution of release events through a fusion pore
Q42223467The effect of neural noise on spike time precision in a detailed CA3 neuron model
Q28473837The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation
Q33907903The effects of geometrical parameters on synaptic transmission: a Monte Carlo simulation study
Q41776597The effects of synaptic noise on measurements of evoked excitatory postsynaptic response amplitudes
Q34085577The kinetics of quantal transmitter release from retinal amacrine cells
Q67580581The minimal inhibitory synaptic currents evoked in neonatal rat motoneurones
Q40587631The nature of quantal transmission at central excitatory synapses.
Q52295610The number of postsynaptic currents necessary to produce locomotor-related cyclic information in neurons in the neonatal rat spinal cord.
Q47297063The origin of quantal size variation: vesicular glutamate concentration plays a significant role.
Q41011898The relationship between receptor-effector unit heterogeneity and the shape of the concentration-effect profile: pharmacodynamic implications
Q34046845The rise times of miniature endplate currents suggest that acetylcholine may be released over a period of time
Q36885427The sequence of events that underlie quantal transmission at central glutamatergic synapses
Q24297813The synaptic vesicle cycle
Q38534666The ubiquitous nature of multivesicular release.
Q34040974Transmitter concentration profiles in the synaptic cleft: an analytical model of release and diffusion.
Q52009138Transmitter metabolism as a mechanism of synaptic plasticity: a modeling study.
Q34110366Transmitter release at the hair cell ribbon synapse
Q71301302Transmitter timecourse in the synaptic cleft: its role in central synaptic function
Q35346189TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus
Q42401437Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies
Q28272276Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes
Q48268895Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices
Q51593302Variation in GABA mini amplitude is the consequence of variation in transmitter concentration
Q42489024Voltage clamp analysis of excitatory synaptic transmission in the avian nucleus magnocellularis

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