Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

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Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELLSIG.2014.04.009
P932PMC publication ID4039615
P698PubMed publication ID24726895
P5875ResearchGate publication ID261608005

P50authorShile HuangQ37840632
P2093author name stringMin Guo
Lei Liu
Qian Zhou
Hai Zhang
Long Chen
Chong Xu
Qian Ren
Chunxiao Liu
Sujuan Chen
Yangjing Ye
Yijiao Xu
P2860cites workPhosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in DrosophilaQ36891456
Role of mTOR in physiology and pathology of the nervous systemQ36959417
mTOR and the control of whole body metabolismQ37406462
The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxiaQ37410754
Pathological roles of MAPK signaling pathways in human diseasesQ37676393
mTOR in aging, metabolism, and cancerQ38073906
Dysregulated mTOR-dependent signaling in neurodegeneration or carcinogenesis: implication for Alzheimer's disease and brain tumors.Q38129230
The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.Q39244135
Cell cycle withdrawal promotes myogenic induction of Akt, a positive modulator of myocyte survivalQ39446473
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cellsQ39741931
AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineQ39776724
Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stressQ39860196
Reactive oxygen species production and MAPK activation are implicated in tetrahydrobiopterin-induced SH-SY5Y cell deathQ39915973
MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosisQ40049797
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathwaysQ40277182
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neuronsQ40583837
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's diseaseQ40887263
Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's diseaseQ44047703
Etiology and pathogenesis of Parkinson disease.Q45952835
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Q21145847
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
mTOR signaling in growth control and diseaseQ24634174
Shedding new light on neurodegenerative diseases through the mammalian target of rapamycinQ27015640
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in strokeQ28240112
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activationQ28568796
Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathwayQ28569460
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell deathQ28577801
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5Q28583048
Parkinson's disease: mechanisms and modelsQ29547424
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Oxidative stress in Parkinson's diseaseQ29618017
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyQ29618101
Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsQ30438876
A highly reproducible rotenone model of Parkinson's diseaseQ30490799
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's diseaseQ33951094
Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease.Q34308036
Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.Q34349122
Levodopa and the progression of Parkinson's diseaseQ34553278
RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.Q34569422
AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathiesQ34696305
Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's diseaseQ35942562
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1Q36158367
Expanding insights of mitochondrial dysfunction in Parkinson's disease.Q36404133
Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neuritesQ36604979
The growing role of mTOR in neuronal development and plasticity.Q36739424
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's diseaseQ36820873
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
cell deathQ2383867
P1104number of pages10
P304page(s)1680-1689
P577publication date2014-04-12
P1433published inCellular SignallingQ1524097
P1476titleActivation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
P478volume26

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cites work (P2860)
Q88252675(-)-Guaiol regulates autophagic cell death depending on mTOR signaling in NSCLC
Q372100351-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells
Q101410046A transition to degeneration triggered by oxidative stress in degenerative disorders
Q58586822AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression
Q47303865AMP-activated protein kinase activation in mediating phenylalanine-induced neurotoxicity in experimental models of phenylketonuria
Q38998405AMPK in Neurodegenerative Diseases
Q64276536Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease
Q47099058Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions
Q36946559Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis.
Q37689001Curcumin targets the TFEB-lysosome pathway for induction of autophagy.
Q91583464Diabetes, a Contemporary Risk for Parkinson's Disease: Epidemiological and Cellular Evidences
Q37745507Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis
Q51691934Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.
Q61453559Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
Q35082315Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.
Q90237363Maduramicin induces cardiac muscle cell death by the ROS-dependent PTEN/Akt-Erk1/2 signaling pathway
Q46309597Manganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders
Q92549553Mechanistic target of rapamycin signaling in mouse models of accelerated aging
Q39199926Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.
Q38539848Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection
Q47988278Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.
Q61801081Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson's disease
Q48290344Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways.
Q43679571Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update
Q59808772Novel Factors of Viral Origin Inhibit TOR Pathway Gene Expression
Q26752769Nutraceuticals in Parkinson's Disease
Q64275885Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway
Q64082784Prioritizing Parkinson's disease genes using population-scale transcriptomic data
Q58702868Punicalagin Exerts Beneficial Functions in 6-Hydroxydopamine-Treated SH-SY5Y Cells by Attenuating Mitochondrial Dysfunction and Inflammatory Responses
Q36356365Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium.
Q92715084Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain
Q34760248Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis
Q27314642Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways
Q52609727Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson's Disease.
Q38607849Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
Q92257585The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
Q26768527The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
Q38765856Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.
Q38855225mTOR Signaling in Parkinson's Disease
Q90145983mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats
Q92993163mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival
Q58795101mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
Q54114653δ-Opioid Receptor Activation Attenuates Hypoxia/MPP+-Induced Downregulation of PINK1: a Novel Mechanism of Neuroprotection Against Parkinsonian Injury.

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