Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality

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Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...512630L
P356DOI10.1371/JOURNAL.PONE.0012630
P8608Fatcat IDrelease_y4tmqn2smjfzvcjwtqv67yw3fu
P932PMC publication ID2935888
P698PubMed publication ID20838620
P5875ResearchGate publication ID46256546

P50authorPiroska E SzabóQ59691359
P2093author name stringDong-Hoon Lee
Purnima Singh
Walter M K Tsark
P2860cites workMolecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoterQ24314790
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenesQ24316326
Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control regionQ24537340
A modified and improved method for bisulphite based cytosine methylation analysisQ24544058
Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genesQ24546155
A mammalian microRNA expression atlas based on small RNA library sequencingQ24644709
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domainsQ24655087
High-resolution profiling of histone methylations in the human genomeQ27860906
The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsQ28142800
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneQ28145754
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusQ28145756
An enhancer deletion affects both H19 and Igf2 expressionQ28288348
H19 acts as a trans regulator of the imprinted gene network controlling growth in miceQ28505959
Dosage-dependent requirement for mouse Vezf1 in vascular system developmentQ28506356
Role of CTCF binding sites in the Igf2/H19 imprinting control regionQ28512182
CTCF-dependent chromatin insulator is linked to epigenetic remodelingQ28585243
Growth retardation versus overgrowth: Silver-Russell syndrome is genetically opposite to Beckwith-Wiedemann syndromeQ37105462
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.Q37277208
The H19 differentially methylated region marks the parental origin of a heterologous locus without gametic DNA methylationQ37424408
Mutagenesis in mice of nuclear hormone receptor binding sites in the Igf2/H19 imprinting control region.Q38314603
Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.Q38328303
A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout developmentQ40022869
A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ.Q40744891
Boundary and insulator elements in chromosomesQ41044068
Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 regionQ41296593
Deletion of a direct repeat element has no effect on Igf2 and H19 imprintingQ43546057
Clinically distinct epigenetic subgroups in Silver-Russell syndrome: the degree of H19 hypomethylation associates with phenotype severity and genital and skeletal anomaliesQ43747410
An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoterQ43978446
Genomic imprinting determines methylation of parental alleles in transgenic miceQ44250721
Recruitment of histone modifications by USF proteins at a vertebrate barrier elementQ45138460
The chicken beta-globin insulator element conveys chromatin boundary activity but not imprinting at the mouse Igf2/H19 domain.Q45987346
Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprintingQ46630830
Allele-specific expression of imprinted genes in mouse migratory primordial germ cells.Q47570006
Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function.Q47590866
The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell developmentQ47811571
The Stockholm classification of stillbirthQ47848959
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.Q48096674
Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.Q48774672
The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during foetal testis developmentQ48886136
A paternal-specific methylation imprint marks the alleles of the mouse H19 geneQ49057890
Parental methylation patterns of a transgenic locus in adult somatic tissues are imprinted during gametogenesisQ49161161
Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1Q28589840
CTCF maintains differential methylation at the Igf2/H19 locusQ28593901
A single nucleotide polymorphism based approach for the identification and characterization of gene expression modulation using MassARRAY.Q31159842
Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoterQ31814866
Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator functionQ33523010
VEZF1 elements mediate protection from DNA methylationQ33523011
H19 imprinting control region methylation requires an imprinted environment only in the male germ line.Q33648826
Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.Q33734866
An intragenic methylated region in the imprinted Igf2 gene augments transcription.Q33757992
Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control regionQ33770481
Genomic imprinting recapitulated in the human beta-globin locusQ33900452
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activitiesQ34067751
CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulatorQ34166628
Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control regionQ34181759
Shared role for differentially methylated domains of imprinted genesQ34276347
A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in DrosophilaQ34352447
H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Q35194017
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulatorsQ35209588
Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Q35211749
The imprinted H19 noncoding RNA is a primary microRNA precursorQ35641214
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylationQ35778363
Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytesQ35875263
Characterization of the chicken beta-globin insulatorQ35956059
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domainsQ35964289
Remote control of gene transcriptionQ36088911
Chromatin boundaries and chromatin domains.Q36238580
CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted regionQ36421340
Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3bQ36802984
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.Q36820044
CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loopQ36959918
The role of insulator elements in large-scale chromatin structure in interphaseQ36962628
Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region.Q37056903
Transcription is required for establishment of germline methylation marks at imprinted genesQ37075687
Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations.Q52088468
Role of a 461-bp G-rich repetitive element in H19 transgene imprinting.Q52178701
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Q52241373
Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.Q54739833
Parental imprinting of the mouse insulin-like growth factor II gene.Q55052428
Embryological and molecular investigations of parental imprinting on mouse chromosome 7.Q55052972
Degree of methylation of transgenes is dependent on gamete of originQ59066120
Genome imprinting phenomena on mouse chromosome 7Q68650344
Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprintingQ70191111
Epigenetic mechanisms underlying the imprinting of the mouse H19 geneQ72094721
The mouse chromosome 7 distal imprinting domain maps to G-bands F4/F5Q73208039
Evidence that insulin is imprinted in the human yolk sacQ73370524
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitiveQ74014247
CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locusQ80159085
Maternal and paternal alleles exhibit differential histone methylation and acetylation at maize imprinted genesQ81768504
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectintrauterine growth restrictionQ1671598
P304page(s)e12630
P577publication date2010-09-08
P1433published inPLOS OneQ564954
P1476titleComplete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality
P478volume5

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cites work (P2860)
Q34186007Differential differences in methylation status of putative imprinted genes among cloned swine genomes
Q36056485Genome-wide methylation analysis in Silver-Russell syndrome patients
Q36316644More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain.
Q34984578The chicken HS4 insulator element does not protect the H19 ICR from differential DNA methylation in yeast artificial chromosome transgenic mouse
Q34648245miR-141 contributes to fetal growth restriction by regulating PLAG1 expression

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