Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1.

scientific article

Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DNAREP.2009.11.005
P932PMC publication ID2829949
P698PubMed publication ID20005182

P50authorSusan S WallaceQ41886664
Ian OdellQ57332034
Nicholas H. HeintzQ109339637
P2093author name stringKheng Newick
David S Pederson
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancerQ21558597
Crystal structure of the nucleosome core particle at 2.8 A resolutionQ22122355
Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signalsQ24292746
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNAQ24531459
Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediateQ24534729
The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activityQ24564283
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsQ24650179
DNA bending and a flip-out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkAQ27621390
Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolutionQ27639217
Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNAQ27656645
Protein production by auto-induction in high density shaking culturesQ27860514
In Vitro and in Vivo Dimerization of Human Endonuclease III Stimulates Its ActivityQ28206421
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2Q28206447
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologueQ28219332
The lac repressor-operator interaction. 3. Kinetic studiesQ28247930
DNA glycosylase recognition and catalysisQ28257898
Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damageQ28263121
AP endonuclease-independent DNA base excision repair in human cellsQ28272662
Quality control by DNA repairQ28608962
Base-excision repair of oxidative DNA damageQ29615373
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsQ33962085
Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspectsQ34214782
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylaseQ34478554
Electron trap for DNA-bound repair enzymes: a strategy for DNA-mediated signalingQ34574415
Repair mechanisms for oxidative DNA damageQ35109446
The enigma of endonuclease VIII.Q35114231
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomesQ35145790
Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.Q35564216
The role of oxidative stress in carcinogenesisQ35639135
Rapid determination of the active fraction of DNA repair glycosylases: a novel fluorescence assay for trapped intermediates.Q35781828
ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes.Q35950275
Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitroQ36089095
Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase IQ36089478
Oxidative stress and apoptosis: a new treatment paradigm in cancer.Q36250951
Oxidative DNA damage repair in mammalian cells: a new perspectiveQ36658399
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.Q36701680
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modificationQ36751371
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1Q36914462
Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1Q36952958
Formation of clustered DNA damage after high-LET irradiation: a reviewQ37138921
Redox signaling between DNA repair proteins for efficient lesion detectionQ37340789
Single-turnover and pre-steady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substratesQ38332366
DNA base excision repair of uracil residues in reconstituted nucleosome core particlesQ39665727
Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.Q41886603
In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment).Q44251057
Direct electrochemistry of endonuclease III in the presence and absence of DNA.Q45973050
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymesQ46749944
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomesQ46886711
In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sitesQ64388853
Replication inhibition and miscoding properties of DNA templates containing a site-specific cis-thymine glycol or urea residueQ74644571
P433issue2
P304page(s)134-143
P577publication date2009-12-11
P1433published inDNA RepairQ3894086
P1476titleNon-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1
P478volume9

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cites work (P2860)
Q26828361Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repair
Q35672253Base excision repair of 8-oxoG in dinucleosomes
Q33908163Base excision repair: a critical player in many games
Q64388986Complex interplay of lesion-specific DNA repair enzyme on bistranded clustered DNA damage harboring Tg:G mismatch in nucleosome core particles
Q37424412Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes
Q92093762Damage sensor role of UV-DDB during base excision repair
Q38614163Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage
Q48353972Differential Ability of Five DNA Glycosylases to Recognize and Repair Damage on Nucleosomal DNA.
Q89234745Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase
Q46564283Effect of the Spiroiminodihydantoin Lesion on Nucleosome Stability and Positioning
Q36306861Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1.
Q36088401FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC.
Q36395737Facilitation of base excision repair by chromatin remodeling
Q47822517Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment.
Q46335843Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes
Q33956975Impact of abasic site orientation within nucleosomes on human APE1 endonuclease activity.
Q30585004Insights into the glycosylase search for damage from single-molecule fluorescence microscopy
Q28248511Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair
Q33931095Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages
Q36102804Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase.
Q51099354Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues.
Q38320847Repair efficiency of (5'S)-8,5'-cyclo-2'-deoxyguanosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine depends on the complementary base
Q36309928Rules of engagement for base excision repair in chromatin
Q46420229The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA.
Q35562087The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

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