Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma

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Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011694986
P356DOI10.1038/ONC.2013.514
P932PMC publication ID4041964
P698PubMed publication ID24292676
P5875ResearchGate publication ID259110326

P2093author name stringK W Gross
C A Jones
C M LeVea
G Hajduczok
S M Caraker
S Sexton
S T Glenn
P2860cites workLoss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasiaQ28143642
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in miceQ28507607
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A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsQ28592210
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Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cellsQ29619410
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatenedQ30433495
Cooperative tumorigenic effects of germline mutations in Rb and p53Q72781894
Expression of a renin/GFP transgene in mouse embryonic, extra-embryonic, and adult tissuesQ73178667
Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1Q73557853
The tissue renin-angiotensin system in human pancreasQ77731503
Neuroendocrine tumors of the pancreasQ83762285
Role of angiotensin in renal vascular development.Q30472568
General method for the modification of different BAC types and the rapid generation of BAC transgenic miceQ33197306
Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populationsQ33425920
What have we learned from gene targeting studies for the renin angiotensin system of the kidney?Q33653909
Expression of murine renin genes in subcutaneous connective tissueQ33844159
Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificityQ33965112
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Q34078091
Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in miceQ34132545
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.Q34146539
Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreasQ34296586
The renin-angiotensin system in the endocrine pancreasQ34542474
The pancreatic renin-angiotensin system: does it play a role in endocrine oncology?Q34542487
Role of endothelial cells in early pancreas and liver developmentQ35029661
A local pancreatic renin-angiotensin system: endocrine and exocrine rolesQ35099138
Of mice and MEN1: Insulinomas in a conditional mouse knockoutQ35660901
Clinical anticancer drug development: targeting the cyclin-dependent kinasesQ35959477
Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitusQ36102603
Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes.Q36273818
The physiology of a local renin-angiotensin system in the pancreasQ36705812
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remainsQ36721554
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitorsQ36959997
In vivo analysis of key elements within the renin regulatory regionQ36977789
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.Q37429020
Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.Q39320072
Pancreatic glucagonoma with and without syndrome. Immunocytochemical study of 5 tumour cases and review of the literatureQ40123472
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellumQ40442891
Expression of neurogenin3 reveals an islet cell precursor population in the pancreasQ40867538
Pancreatic neurogenin 3-expressing cells are unipotent islet precursorsQ42102476
Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.Q42648216
Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.Q42810962
Mice deficient in both p53 and Rb develop tumors primarily of endocrine originQ43467108
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesQ43470250
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic isletsQ44727498
Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantationQ46300746
Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasisQ46782176
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.Q52544495
Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.Q53378102
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.Q55043460
Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumoursQ60585297
Glucagonomas of transgenic mice express a wide range of general neuroendocrine markers and bioactive peptidesQ61852966
P433issue50
P407language of work or nameEnglishQ1860
P921main subjectpancreasQ9618
P304page(s)5706-5715
P577publication date2013-12-02
P1433published inOncogeneQ1568657
P1476titleConditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma
P478volume33

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