Targeting Iron Homeostasis in Acute Kidney Injury

scientific article

Targeting Iron Homeostasis in Acute Kidney Injury is …
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scholarly articleQ13442814

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P356DOI10.1016/J.SEMNEPHROL.2016.01.003
P932PMC publication ID5439503
P698PubMed publication ID27085736

P2093author name stringAnupam Agarwal
Vyvyca J Walker
P2860cites workShould medical directors assume responsibility for facility-specific outcomes?Q83861126
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1Q24296806
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overloadQ28139987
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulationQ28140006
Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia miceQ28241576
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasisQ28264540
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory networkQ28280607
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesQ28388335
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cellsQ28509880
Scara5 is a ferritin receptor mediating non-transferrin iron deliveryQ28587430
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injuryQ28591880
Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron HomeostasisQ30300347
Acute kidney injury associated with cardiac surgeryQ30444258
Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizonQ30444266
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injuryQ33753800
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injuryQ33830710
Mucolipins: Intracellular TRPML1-3 channelsQ33838349
Urinary biomarkers in the clinical prognosis and early detection of acute kidney injuryQ34362635
Oxygen free radicals in ischemic acute renal failure in the rat.Q34616205
Iron Imports. V. Transport of iron through the intestinal epitheliumQ34651772
Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice.Q34760221
Control of intracellular heme levels: heme transporters and heme oxygenasesQ34810793
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgeryQ46423060
Fundamental role for HO-1 in the self-protection of renal allograftsQ47766207
Heme carrier protein 1 transports heme and is involved in heme-Fe metabolismQ47914337
Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injuryQ47949709
Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissuesQ48437047
Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin.Q52064221
Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress.Q53547569
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Oxidative Stress, Macrophage Infiltration and CD163 Expression Are Determinants of Long-Term Renal Outcome in Macrohematuria-Induced Acute Kidney Injury of IgA NephropathyQ63684376
Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expressionQ63684378
Hemeoxygenase-1 and Renal Ischaemia-Reperfusion InjuryQ64447700
Receptor-modulated iron release from transferrin: differential effects on N- and C-terminal sitesQ68000639
Hemopexin joins transferrin as representative members of a distinct class of receptor-mediated endocytic transport systemsQ68077587
Superoxide-mediated release of iron from ferritin by some flavoenzymesQ68458240
Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failureQ69836533
Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injuryQ70224286
Role of iron in postischemic renal injury in the ratQ70413528
Evidence for cytochrome P-450 as a source of catalytic iron in myoglobinuric acute renal failureQ71568673
Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox stateQ72844148
In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicityQ74165125
Role of cytochrome P-450 as a source of catalytic iron in cisplatin-induced nephrotoxicityQ77650651
Treatment of acute renal failureQ77682455
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in miceQ77719701
Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal InjuryQ79091417
Delayed Administration of ??-Melanocyte-Stimulating Hormone or Combined Therapy with Bay 11-7085 Protects Against Gut Ischemia???Reperfusion InjuryQ79167572
Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLFQ83364195
Ferroportin/IREG-1/MTP-1/SLC40A1 modulates the uptake of iron at the apical membrane of enterocytesQ35596253
Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidneyQ35608905
Genetic polymorphisms of heme-oxygenase 1 (HO-1) may impact on acute kidney injury, bronchopulmonary dysplasia, and mortality in premature infantsQ35629912
Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human diseaseQ35794543
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in miceQ35848332
Plasma and urinary heme oxygenase-1 in AKI.Q35982380
Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKIQ36003153
Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort studyQ36070477
Physiologic implications of metal-ion transport by ZIP14 and ZIP8Q36138755
Liver iron transportQ36177913
Iron Imports. II. Iron uptake at the apical membrane in the intestineQ36312525
Renal cortical hemopexin accumulation in response to acute kidney injuryQ36454161
Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epitheliaQ36507261
Regulation of iron acquisition and iron distribution in mammalsQ36514389
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.Q37129387
Iron transport and the kidneyQ37337447
Cellular iron transportQ37432492
Heme scavenging and the other facets of hemopexinQ37570497
Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor.Q37602863
pH and the recycling of transferrin during receptor-mediated endocytosisQ37609089
Heme oxygenase-1 and acute kidney injuryQ38166176
Role of reactive oxygen metabolites in experimental glomerular diseaseQ38682345
The importance of iron, calcium and free radicals in reperfusion injury: an overview of studies in ischaemic rabbit kidneysQ38723811
Superoxide dependent iron release from ferritin in inflammatory diseasesQ39196130
Acute kidney injury, mortality, length of stay, and costs in hospitalized patientsQ39730814
Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane traffickingQ39762547
Renal and electrolyte disturbances associated with cisplatinQ40317395
In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation.Q40460712
Role of iron and oxygen-derived free radicals in ischemia-reperfusion injury.Q40665929
Macrophage and epithelial cell H-ferritin expression regulates renal inflammationQ41468351
A newly developed kit for the measurement of urinary liver-type fatty acid-binding protein as a biomarker for acute kidney injury in patients with critical careQ41603632
Hydrogen peroxide cytotoxicity in LLC-PK1 cells: A role for ironQ41659475
Release of iron from ferritin by xanthine oxidase. Role of the superoxide radicalQ41786699
Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury.Q41815546
Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive elementQ41920926
Gentamicin-induced mobilization of iron from renal cortical mitochondriaQ42286161
In vivo characterization of renal iron transport in the anaesthetized rat.Q42624144
Increase in bleomycin-detectable iron in ischaemia/reperfusion injury to rat kidneysQ42796944
The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in ratsQ43636476
Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseasesQ43796001
Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicityQ43832438
Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentrationQ44505496
Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse.Q46023821
P433issue1
P304page(s)62-70
P577publication date2016-01-01
P1433published inSeminars in NephrologyQ15761561
P1476titleTargeting Iron Homeostasis in Acute Kidney Injury
P478volume36

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cites work (P2860)
Q89006939Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney
Q39364649Acute kidney injury: emerging pharmacotherapies in current clinical trials.
Q33584976Change in iron metabolism in rats after renal ischemia/reperfusion injury
Q92988982Ferritin in Kidney and Vascular Related Diseases: Novel Roles for an Old Player
Q39111132Heme Oxygenase 1 as a Therapeutic Target in Acute Kidney Injury
Q38838112Postischemic microvasculopathy and endothelial progenitor cell-based therapy in ischemic AKI: update and perspectives
Q57801723Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation
Q99712217The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury
Q98289721The effect of hepcidin in rats with renal ischemia/reperfusion injury
Q38809791The in vivo evidence for regulated necrosis

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