C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2017.00592
P932PMC publication ID5442170
P698PubMed publication ID28596769

P2093author name stringJinhua Lu
Uday Kishore
P2860cites workAn alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental developmentQ24298379
Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activationQ24299377
Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1qQ24309368
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition propertiesQ24320322
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypesQ24337767
Human genes for complement components C1r and C1s in a close tail-to-tail arrangementQ24647917
C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cellsQ24670661
Macrophage heterogeneity in tissues: phenotypic diversity and functionsQ26861223
Inflamm-aging. An evolutionary perspective on immunosenescenceQ28141817
Complement. First of two partsQ28210663
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupusQ28212039
Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotypeQ28238306
The classical complement cascade mediates CNS synapse eliminationQ28261273
Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: evidence for an independent production of the C1 subunitsQ28276981
Augmented Wnt signaling in a mammalian model of accelerated agingQ28506533
Interferon and granulopoiesis signatures in systemic lupus erythematosus bloodQ29615064
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosisQ29619965
Apoptosis: controlled demolition at the cellular levelQ29620114
Enhanced synaptic connectivity and epilepsy in C1q knockout miceQ30494456
Maturation of dendritic cells abrogates C1q production in vivo and in vitroQ75272880
Antibodies against double-stranded DNA and development of polymyositis during treatment with interferonQ77111618
The significance of the lupus globulin; nucleoprotein reactionQ78367789
Dendritic cells in the arterial wall express C1q: potential significance in atherogenesisQ79106760
Prion protein activates and fixes complement directly via the classical pathway: implications for the mechanism of scrapie agent propagation in lymphoid tissueQ79871619
Common silent mutations in all types of hereditary complement C1q deficienciesQ81019615
Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosusQ81129128
Immune modulation of human dendritic cells by complementQ81360867
C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulationQ83689744
Complement C1q production by osteoclasts and its regulation of osteoclast developmentQ84588704
C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesisQ84596359
Serum C1q as a novel biomarker of sarcopenia in older adultsQ86221304
Elucidation of the substrate specificity of the C1s protease of the classical complement pathwayQ33223538
The key role of nucleosomes in lupusQ33633300
Systemic lupus erythematosus, complement deficiency, and apoptosisQ34082803
Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosusQ34224780
The ancestral complement system in sea urchinsQ34286998
Proteases of the complement systemQ34293205
Advances in lupus genetics and epigeneticsQ34464114
Genome duplication, extinction and vertebrate evolutionQ34526190
Evolution of enzyme cascades from embryonic development to blood coagulationQ34536452
Phagocytosis of microbes: complexity in actionQ34542300
Steady-state and inflammatory dendritic-cell developmentQ34591334
C1q and its growing family.Q34633739
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexesQ34729450
Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune systemQ34838060
Recent insights into the genetic basis of systemic lupus erythematosusQ34980873
Triggers for anti-chromatin autoantibody production in SLE.Q35045914
Transcriptional Factor PU.1 Regulates Decidual C1q Expression in Early Pregnancy in Human.Q35087349
Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.Q35227723
Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophagesQ35266807
Autoantigenicity of nucleolar complexes.Q35556338
The role of complement in the development of systemic lupus erythematosusQ35698485
C1q and tumor necrosis factor superfamily: modularity and versatilityQ35885821
A protective role for innate immunity in systemic lupus erythematosusQ35906102
C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteinsQ36049951
Chromatographic resolution of the first component of human complement into three activitiesQ36266154
The classical and regulatory functions of C1q in immunity and autoimmunityQ36299455
Regulation of cytokine production during phagocytosis of apoptotic cellsQ36394974
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitorsQ36402594
Stem cells, ageing and the quest for immortality.Q36523915
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activationQ36541076
Genomic view of the evolution of the complement system.Q36560366
Complement deficiencies in humans and animals: links to autoimmunityQ36572977
The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.Q36752476
The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies.Q36927866
The macrophage: past, present and futureQ36986722
A dramatic increase of C1q protein in the CNS during normal aging.Q37093902
Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosisQ37246964
Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complementQ37339284
Complement activation and inhibition: a delicate balance.Q37368654
Analysis of the Interaction between Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR.Q37496810
Clinical significance of complement deficienciesQ37598280
Complement the cell death.Q37603273
Cutaneous manifestations of complement deficienciesQ37778649
Evolution of blood coagulation and fibrinolysisQ37838990
Complement deficiency states and associated infectionsQ37882132
CTRP family: linking immunity to metabolismQ37977232
Regulation of complement protein biosynthesis in mononuclear phagocytes.Q38164718
Clinical presentation of human C1q deficiency: How much of a lupus?Q38407945
Inflammatory cascades mediate synapse elimination in spinal cord compression.Q38617047
Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chainsQ39654001
Activation and control of the complement systemQ39761363
Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activationQ39980543
Circular-dichroism and electron-microscopy studies of human subcomponent C1q before and after limited proteolysis by pepsinQ40030966
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brainQ40306336
Complement protein C1q forms a complex with cytotoxic prion protein oligomersQ41048016
Biosynthesis of human ficolin, an Escherichia coli-binding protein, by monocytes: comparison with the synthesis of two macrophage-specific proteins, C1q and the mannose receptorQ41160601
Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probesQ41645497
The human c1q globular domain: structure and recognition of non-immune self ligandsQ42113914
Subunit composition and structure of subcomponent C1q of the first component of human complementQ42917134
Mannose-binding lectin engagement with late apoptotic and necrotic cellsQ44600225
Complement facilitates early prion pathogenesisQ48930440
Systemic lupus erythematosus.Q53495545
The phylogeny of the complement system and the origins of the classical pathway.Q53569256
Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.Q54014234
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infectionQ57415587
Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1sQ67290039
Proteolysis of the heavy chain of major histocompatibility complex class I antigens by complement component C1sQ67654476
Evolution of the complement systemQ67788520
Autoimmune Phenomena in Patients with Malignant Carcinoid Tumors During Interferon-α TreatmentQ67918972
Discovery of the LE cell and its morphologyQ70119034
Antibodies to Polynucleotides: Distribution in Human SerumsQ71262055
Proteolytic enzymes in coagulation, fibrinolysis, and complement activation. IntroductionQ72683915
C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisitedQ73326011
[Absorption of L. E. factor by isolated cell nuclei]Q73560726
Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgGQ73910753
[Systemic lupus erythematosus preceded by false-positive serologic tests for syphilis: presentation of five cases]Q73949259
The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding protein-5 in fibroblast mediumQ74303796
Mechanism of immune hemolysis: recognition of two steps in the conversion of EAC' 1,4,2 to EQ74765038
P921main subjectproteolysisQ33123
P304page(s)592
P577publication date2017-05-24
P1433published inFrontiers in ImmunologyQ27723748
P1476titleC1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
P478volume8

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cites work (P2860)
Q47603328Broad Susceptibility of Nucleolar Proteins and Autoantigens to Complement C1 Protease Degradation
Q90057501Complement C1r serine protease contributes to kidney fibrosis
Q58572640Complement Component C1q as Serum Biomarker to Detect Active Tuberculosis
Q52310303Complement Component C1q: Historical Perspective of a Functionally Versatile, and Structurally Unusual, Serum Protein.
Q98735454Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System
Q64092937Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants
Q64068000Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
Q55130392The Complement System and C1q in Chronic Hepatitis C Virus Infection and Mixed Cryoglobulinemia.
Q90211958The Ligands for Human IgG and Their Effector Functions