Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially with BMP-2 and Wnt5a

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Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially with BMP-2 and Wnt5a is …
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scholarly articleQ13442814

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P356DOI10.5966/SCTM.2016-0020
P932PMC publication ID5442752
P698PubMed publication ID28170184

P2093author name stringHicham Drissi
David N Paglia
Farhang Alaee
Ryu Yoshida
Jason D Gibson
Rosa M Guzzo
Michael B O'Sullivan
P2860cites workAutologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histologyQ24796118
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Multilineage potential of adult human mesenchymal stem cellsQ27860737
Embryonic stem cell lines derived from human blastocystsQ27861010
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementQ27861120
Two- to 9-year outcome after autologous chondrocyte transplantation of the kneeQ28144816
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryoQ28505232
Current strategies for articular cartilage repair.Q33214036
Detailed examination of cartilage formation and endochondral ossification using human mesenchymal stem cells.Q33219767
Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrowQ33308730
Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regenerationQ33346219
Quantitative RT-PCR gene expression analysis of laser microdissected tissue samplesQ33455428
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilageQ34060569
Microfracture techniques in the treatment of osteochondral injuriesQ34277499
Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial.Q34302678
Cartilage repair using human embryonic stem cell-derived chondroprogenitorsQ34429019
Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cellsQ50448535
Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4.Q50513371
Differentiation of Human Induced Pluripotent Stem Cells to Chondrocytes.Q50556720
Generation of articular chondrocytes from human pluripotent stem cells.Q50587550
In vitro derivation of chondrogenic cells from human embryonic stem cells.Q50721028
Effects of culture conditions and bone morphogenetic protein 2 on extent of chondrogenesis from human embryonic stem cells.Q50913076
Tissue engineering with chondrogenically differentiated human embryonic stem cells.Q50990961
Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture.Q51474214
Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture.Q51610394
Macroscopic cartilage formation with embryonic stem-cell-derived mesodermal progenitor cells.Q52107063
Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.Q52110044
Articular cartilage: injuries and potential for healing.Q52532281
Fibrin glue: a scaffold for cellular-based therapy in a critical-sized defect.Q53272762
Single-cell transcript analysis of human embryonic stem cells.Q54449365
Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo.Q54733698
Derivation of Clinically Compliant MSCs from CD105+, CD24− Differentiated Human ESCsQ56915439
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID miceQ59348563
Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gelsQ70475251
Morphological examination during in vitro cartilage formation by human mesenchymal stem cellsQ81039082
Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cellsQ84954336
Tissue engineering: chondrocytes and cartilageQ34731117
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapiesQ34744250
Articular cartilage injuries.Q34827263
Treatment with embryonic stem-like cells into osteochondral defects in sheep femoral condylesQ34979168
Surface markers and gene expression to characterize the differentiation of monolayer expanded human articular chondrocytesQ35135102
Treatment of articular cartilage lesions of the knee by microfracture or autologous chondrocyte implantation: a systematic reviewQ35557416
Differentiation and enrichment of expandable chondrogenic cells from human embryonic stem cells in vitro.Q35893343
Directing stem cell differentiation into the chondrogenic lineage in vitroQ35973017
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursorsQ35995189
Aging of mesenchymal stem cellsQ36323407
Major biological obstacles for persistent cell-based regeneration of articular cartilage.Q36392311
Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppressionQ36482263
Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cellsQ36563069
In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cellsQ37081650
Self-renewal and differentiation capacity of young and aged stem cellsQ37148596
The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regenerationQ38289876
Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem cellsQ38860622
Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs.Q38904482
Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells.Q39682124
WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways.Q39688990
Coculture of human embryonic stem cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiationQ39835008
Chondrogenic differentiation of human embryonic stem cells: the effect of the micro-environmentQ40254909
Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesisQ40752065
Induction of chondrogenesis from human embryonic stem cells without embryoid body formation by bone morphogenetic protein 7 and transforming growth factor beta1.Q42463730
Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspectsQ44133626
Dual roles of Wnt signaling during chondrogenesis in the chicken limbQ44509921
Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansionQ45877573
Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cellsQ46286017
Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect modelQ46759920
Gene expression during redifferentiation of human articular chondrocytesQ47286038
Repair of human articular cartilage after implantation of autologous chondrocytes.Q47622195
Derivation and Chondrogenic Commitment of Human Embryonic Stem Cell-Derived Mesenchymal ProgenitorsQ47635020
Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitroQ47988998
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectcartilageQ502730
P304page(s)40-50
P577publication date2016-08-05
P1433published inStem Cells Translational MedicineQ26842216
P1476titleRegeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially with BMP-2 and Wnt5a
P478volume6

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cites work (P2860)
Q37692561Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis
Q47110415Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue
Q47095797Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine.
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Q91640686Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture
Q90392236MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME
Q90403463Platelet-Rich Plasma, Hydroxyapatite, and Chitosan in the Bone and Cartilaginous Regeneration of Femoral Trochlea in Rabbits: Clinical, Radiographic, and Histomorphometric Evaluations
Q57169843Repair of Damaged Articular Cartilage: Current Approaches and Future Directions
Q51734158Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures.
Q91601348Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review

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