Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo

scientific article published on October 21, 2010

Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo is …
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P6179Dimensions Publication ID1015055098
P356DOI10.1186/1471-2407-10-571
P953full work available at URLhttps://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-571
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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20964812/pdf/?tool=EBI
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P932PMC publication ID2976754
P698PubMed publication ID20964812
P5875ResearchGate publication ID47518615

P2093author name stringYves Le Vern
Denis Rasschaert
Ginette Dambrine
Sylvie Laurent
Souheila Amor
Sylvie Remy
P2860cites workTwo cell lines from lymphomas of Marek's diseaseQ69366456
Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterusQ74411792
Alternative splicing and nonsense-mediated mRNA decay regulate gene expression of serum response factorQ80608304
Vaccination against Marek's disease reduces telomerase activity and viral gene transcription in peripheral blood leukocytes from challenged chickensQ81743463
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Different levels of alternative splicing among eukaryotesQ24670390
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
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On the road to immortality: hTERT upregulation in cancer cellsQ28257238
The RNA component of human telomeraseQ28288330
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humansQ29615184
Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissuesQ33255709
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Mechanism of telomerase activation by v-Rel and its contribution to transformationQ34233162
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAsQ34583829
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activityQ34785876
Telomerase: regulation, function and transformationQ36103259
The splicing machinery is a genetic modifier of disease severityQ36204731
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.Q36885740
Pre-mRNA splicing aberrations and cancer.Q36992038
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Structure-function relationships in telomerase genes.Q37472153
Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)Q37535521
Involvement of the oncoprotein c-Myc in viral telomerase RNA gene regulation during Marek's disease virus-induced lymphomagenesisQ38304448
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activityQ38311950
Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cellsQ39511317
The RNA subunit of telomerase is encoded by Marek's disease virusQ39748978
Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.Q40091384
Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA.Q40186605
Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissuesQ40408840
Induction of telomerase activity in avian lymphoblastoid cell line transformed by Marek's disease virus, MDCC-MSB1.Q40539496
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activityQ40825989
Changes in telomerase activity and telomere length during human T lymphocyte senescenceQ41120744
Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant.Q42203404
Cell lines derived from avian lymphomas exhibit two distinct phenotypesQ42819170
Extensive coupling of alternative splicing of pre-mRNAs of serine/arginine (SR) genes with nonsense-mediated decayQ43253390
Nitric oxide inhibits Marek's disease virus replication but is not the single decisive factor in interferon-gamma-mediated viral inhibition.Q45739904
Establishment and characterization of a chicken hepatocellular carcinoma cell line, LMH.Q52832723
Nonsense-mediated mRNA decay: target genes and functional diversification of effectorsQ57279018
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of ullrich disease fibroblastsQ58323613
Possible Regulation of Telomerase Activity by Transcription and Alternative Splicing of Telomerase Reverse Transcriptase in Human MelanomaQ60589822
P407language of work or nameEnglishQ1860
P921main subjectenzymologic gene expression regulationQ70688407
alternative mRNA splicing, via spliceosomeQ21114084
neoplastic gene expression regulationQ66660300
P304page(s)571
P577publication date2010-10-21
P1433published inBMC CancerQ326300
P1476titleAlternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo
P478volume10