Dolutegravir: clinical efficacy and role in HIV therapy

scientific article

Dolutegravir: clinical efficacy and role in HIV therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/2040622314530461
P932PMC publication ID4049127
P698PubMed publication ID24982751

P2093author name stringAlessandra Fantauzzi
Ivano Mezzaroma
P2860cites workLife expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individualsQ22242705
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Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteersQ33559015
Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the phase III VIKING-3 studyQ33880221
Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo AcidQ34144064
Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING StudyQ34316681
Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trialQ34373867
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Potential benefit of dolutegravir once daily: efficacy and safetyQ36603416
Dolutegravir in antiretroviral-naive adults with HIV-1: 96-week results from a randomized dose-ranging studyQ36959425
The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adultsQ37244858
Clinical pharmacokinetic, pharmacodynamic and drug-interaction profile of the integrase inhibitor dolutegravirQ37248656
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Next-generation integrase inhibitors : where to after raltegravir?Q38081866
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Antiretroviral regimens sparing agents from the nucleoside(tide) reverse transcriptase inhibitor class: a review of the recent literatureQ38170576
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen (Stribild®): a review of its use in the management of HIV-1 infection in adultsQ38171345
Dolutegravir: a new integrase strand transfer inhibitor for the treatment of HIV.Q38172029
Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexesQ38627271
Lopinavir/ritonavir combined with raltegravir or tenofovir/emtricitabine in antiretroviral-naive subjects: 96-week results of the PROGRESS studyQ39394695
Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravirQ39421000
Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infectionQ39570904
Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of dolutegravir as 10-day monotherapy in HIV-1-infected adultsQ39734035
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolatesQ40417023
The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitnessQ41884057
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitorQ42111140
Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitorsQ42241128
Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integraseQ42265700
Safety and feasibility of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors + atazanavir/ritonavir with virological suppression (AtazanaQ42276740
Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING studyQ42285688
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.Q42714414
Efficacy and safety of etravirine at week 96 in treatment-experienced HIV type-1-infected patients in the DUET-1 and DUET-2 trialsQ42839639
Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK.Q43451461
Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 studyQ44304694
Simplification to dual antiretroviral therapy including a ritonavir-boosted protease inhibitor in treatment-experienced HIV-1-infected patientsQ45075780
Implications of integrase inhibitors for HIV-infected transplantation recipients: raltegravir and dolutegravir (S/GSK 1349572).Q45991778
HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic reviewQ46180060
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infectionQ46466415
Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trialQ58000796
Cross-resistance Profile of the Novel Integrase Inhibitor Dolutegravir (S/GSK1349572) Using Clonal Viral Variants Selected in Patients Failing RaltegravirQ58228900
Factors associated with complete adherence to HIV combination antiretroviral therapyQ83881805
Dual raltegravir/etravirine combination in virologically suppressed HIV-1-infected patients on antiretroviral therapyQ84919973
P433issue4
P921main subjectdolutegravirQ937224
P304page(s)164-177
P577publication date2014-07-01
P1433published inTherapeutic advances in chronic diseaseQ26842871
P1476titleDolutegravir: clinical efficacy and role in HIV therapy
P478volume5

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cites work (P2860)
Q370957083-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.
Q40517770A Two-Way Steady-State Pharmacokinetic Interaction Study of Doravirine (MK-1439) and Dolutegravir
Q56794669Cellulose Acetate Phthalate and Antiretroviral Nanoparticle Fabrications for HIV Pre-Exposure Prophylaxis
Q40695098Integrase Strand Transfer Inhibitors (INSTIs) Resistance Mutations in HIV-1 Infected Turkish Patients
Q64988862Treatment Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents: An Update.

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