Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments.

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Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..107.3058B
P356DOI10.1073/PNAS.0812851107
P932PMC publication ID2840293
P698PubMed publication ID20133667
P5875ResearchGate publication ID41408519

P50authorThomas HöferQ37380437
Alexander ScheffoldQ47160865
P2093author name stringKevin Thurley
Michael Flossdorf
Maurus de la Rosa
Dorothea Busse
Kirstin Hobiger
P2860cites workFOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Q24300625
Modeling T cell antigen discrimination based on feedback control of digital ERK responsesQ24814731
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation timeQ29547822
Regulatory T cells and immune toleranceQ29616864
Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression.Q33300337
Regulatory T cells in autoimmmunity*.Q33904108
A systematic approach to vaccine complexity using an automaton model of the cellular and humoral immune system. I. Viral characteristics and polarized responsesQ33928047
Shouts, whispers and the kiss of death: directional secretion in T cellsQ34001889
Computational modeling of the EGF-receptor system: a paradigm for systems biologyQ34164423
Enhancement and diversification of IFN induction by IRF-7-mediated positive feedbackQ34532725
Interleukin-2 is essential for CD4+CD25+ regulatory T cell functionQ34550108
Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signalingQ34582454
The biology of interleukin-2.Q34585827
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cellsQ34709777
Digital signaling and hysteresis characterize ras activation in lymphoid cellsQ34929087
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitroQ35171080
Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tangoQ36097043
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2Q36229586
The dichotomous role of IL-2: tolerance versus immunity.Q36387343
The quantal theory of immunityQ36391829
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigenQ36403106
Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune diseaseQ36708311
Molecular orchestration of differentiation and function of regulatory T cellsQ37390979
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.Q37418499
CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.Q40463447
IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansionQ40614166
The IL-2/IL-2 receptor system: a current overviewQ40891371
Transcriptional control networks of cell differentiation: insights from helper T lymphocytesQ42464881
IL-2 induces a competitive survival advantage in T lymphocytesQ46466198
IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competitionQ47644295
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.Q47898451
The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elementsQ48349941
Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response.Q52072842
IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells.Q52918370
The interleukin-2 T-cell system: a new cell growth model.Q55062562
Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cellsQ79754976
Competition for cytokines: T(reg) cells take allQ79914774
Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activityQ81512229
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3058-3063
P577publication date2010-01-28
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCompeting feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments
P478volume107