Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion

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Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1029819459
P356DOI10.1186/BCR3441
P932PMC publication ID4053239
P698PubMed publication ID23786849
P5875ResearchGate publication ID240308294

P50authorShafaat RabbaniQ77959450
P2093author name stringSuhad Ali
Meiou Dai
Nadège Fils-Aimé
Amal A Al-Odaini
Ani Arakelian
Jimin Guo
Manuel A Villatoro
Jean Lebrun
P2860cites workStructural basis of heteromeric smad protein assembly in TGF-beta signalingQ24302541
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb functionQ24311568
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrestQ24319021
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Identification of G1 kinase activity for cdk6, a novel cyclin D partnerQ24324587
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial functionQ24554383
Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage ResponseQ24616966
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancerQ24633201
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6Q24652510
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complexQ24670129
Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivationQ24684054
The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerizationQ27630131
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signalingQ27765346
Cyclin D1 in breast cancer pathogenesisQ27824841
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferationQ28117650
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformationQ28140810
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNAQ28183697
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycleQ28189224
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclinsQ28201264
Cyclin D as a therapeutic target in cancerQ28242623
Invadopodia: specialized cell structures for cancer invasionQ28251084
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motilityQ28261746
TGFβ signalling in contextQ28275410
Minireview: Cyclin D1: normal and abnormal functionsQ28279069
TGFbeta in CancerQ28288866
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesisQ28291864
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distributionQ28300442
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor geneQ28300451
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Requirement for CDK4 kinase function in breast cancerQ28585905
Mouse development and cell proliferation in the absence of D-cyclins.Q52088064
Overexpression of cyclin D1 is associated with metastatic prostate cancer to boneQ61510111
Association of human cyclin E with a periodic G1-S phase protein kinaseQ67505073
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-betaQ71995235
PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomasQ72132823
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylationQ73715187
Lost in migrationQ83155814
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisitedQ29547915
G1 phase progression: cycling on cueQ29615162
TGF-beta signaling in tumor suppression and cancer progressionQ29615427
Cancer metastasis: building a frameworkQ29616783
Transcriptional control by the TGF-beta/Smad signaling systemQ29618985
p21 in cancer: intricate networks and multiple activitiesQ30436015
TGF-beta signaling: positive and negative effects on tumorigenesisQ31034737
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumorsQ33565565
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFβ-mediated breast cancer cell migration and invasion.Q33739245
Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodiaQ33840016
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathwayQ33884776
Specific protection against breast cancers by cyclin D1 ablationQ34082446
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic miceQ34342812
G1 cell-cycle control and cancerQ34368858
TGF-beta signaling in cancer--a double-edged swordQ34421804
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic responseQ34659897
Cyclin D1 determines mitochondrial function in vivoQ35070938
The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancerQ35096122
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancersQ35099578
Cyclin D1 governs adhesion and motility of macrophagesQ35153599
Targeting the TGF beta signaling network in human neoplasiaQ35169582
Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteinsQ36310068
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancerQ36516410
CDK inhibitors: cell cycle regulators and beyondQ37081857
Nuclear cyclin D1: an oncogenic driver in human cancerQ37470373
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breastQ37595164
Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasisQ39441340
Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cellsQ39736048
Cyclin D1 induction of cellular migration requires p27(KIP1).Q40218988
Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularizationQ40245226
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.Q40274206
Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissuesQ40657562
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis.Q40756117
p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear exportQ40761763
Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancerQ40959992
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signalingQ41493003
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.Q41496142
Cyclin D1 gene (CCND1) mutations in endometrial cancerQ44573130
A census of amplified and overexpressed human cancer genesQ44951771
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.Q47420791
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P2507corrigendum / erratumErratum to: Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasionQ42371698
P433issue3
P921main subjectbreast cancerQ128581
cell migrationQ189092
P304page(s)R49
P577publication date2013-06-20
P1433published inBreast Cancer ResearchQ2208481
P1476titleCyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion
P478volume15