Shorter telomeres may indicate dementia status in older individuals with Down syndrome.

scientific article

Shorter telomeres may indicate dementia status in older individuals with Down syndrome. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROBIOLAGING.2008.06.001
P932PMC publication ID2842474
P698PubMed publication ID18635289
P5875ResearchGate publication ID51409758

P50authorWarren B ZigmanQ60299907
P2093author name stringNicole Schupf
Hong Gu
Deborah Pang
Lingling Ye
Edmund C Jenkins
Sharon J Krinsky-McHale
Milen Velinov
Wayne P Silverman
Samantha A Ni
P2860cites workIn vivo loss of telomeric repeats with age in humansQ68048615
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Mild cognitive impairment: clinical characterization and outcomeQ28140626
Obesity, cigarette smoking, and telomere length in womenQ29615467
Telomere length predicts replicative capacity of human fibroblastsQ29615745
Differences in telomere length between homologous chromosomes in humansQ33941145
Telomere reduction in human colorectal carcinoma and with ageingQ34037761
Telomeres and telomerase: basic science implications for agingQ34368289
Phosphorylation of H2AX at short telomeres in T cells and fibroblastsQ34550319
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.Q34729916
Onset of dementia is associated with age at menopause in women with Down's syndromeQ35547822
Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive ImpairmentQ35868499
Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patientsQ36488856
Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complexQ36934008
Heterogeneity in telomere length of human chromosomes.Q39426746
Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.Q46669549
Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects.Q47254637
Telomeres shorten with age in rat cerebellum and cortex in vivoQ47607522
Incidence and prevalence of dementia in elderly adults with mental retardation without down syndromeQ51942821
Dementia in adults with mental retardation: assessment at a single point in timeQ51942825
Telomere shortening in T cells correlates with Alzheimer's disease statusQ51951567
Diagnosis of dementia in individuals with intellectual disabilityQ52002220
Sequence of cognitive decline in dementia in adults with Down's syndromeQ52022663
Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndromeQ52199189
Test battery for the diagnosis of dementia in individuals with intellectual disability. Working Group for the Establishment of Criteria for the Diagnosis of Dementia in Individuals with Intellectual DisabilityQ53334862
Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementiaQ53664560
Mild cognitive impairmentQ57306293
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosisQ57445853
P433issue5
P921main subjectdementiaQ83030
P304page(s)765-771
P577publication date2008-07-16
P1433published inNeurobiology of AgingQ7002141
P1476titleShorter telomeres may indicate dementia status in older individuals with Down syndrome
P478volume31

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cites work (P2860)
Q64901240Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.
Q37272133Alzheimer's Disease in Adults with Down Syndrome
Q90250140An improved method for detecting telomere size differences in T-lymphocyte interphases from older people with Down syndrome with and without mild cognitive impairment
Q38129325Atypical aging in down syndrome
Q38797902Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
Q36131210Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures
Q39031905Correlation between terminal restriction fragments and flow-FISH measures in samples over wide range telomere lengths.
Q36007563Does the cryogenic freezing process cause shorter telomeres?
Q22252371Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging
Q45146960Functional variant in methionine synthase reductase decreases the risk of Down syndrome in China
Q37039281Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome.
Q38600853Longitudinal telomere shortening and early Alzheimer's disease progression in adults with down syndrome.
Q36153435Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns
Q22252694Molecular genetic analysis of Down syndrome
Q53002494Mosaicism for trisomy 21: a review
Q83844485Reduced telomere length in individuals with FMR1 premutations and full mutations
Q38571894Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential.
Q50548260Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome
Q35794673Telomere shortening in Down syndrome patients--when does it start?
Q33560787Telomere shortening in neurological disorders: an abundance of unanswered questions
Q54576094Telomeres in Trisomy 21 Amniocytes

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