Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action

scientific article published on November 1, 1992

Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.36.11.2418
P953full work available at URLhttps://europepmc.org/articles/PMC284346
https://europepmc.org/articles/PMC284346?pdf=render
P932PMC publication ID284346
P698PubMed publication ID1489185

P2093author name stringStåhle L
B. Oberg
B. Wahren
E. Ljungdahl-Ståhle
Ljungdahl-Ståhle E
D. Böttiger
E. Guzenda
L. Ståhle
P2860cites work3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitroQ24609215
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Antiviral effects of 3'-fluorothymidine and 3'-azidothymidine in cynomolgus monkeys infected with simian immunodeficiency virusQ28335398
An analysis of the inhibition of replication of HIV and MuLV by some 3'-blocked pyrimidine analogsQ28339419
Structure-activity relationships of fluorinated nucleoside analogs and their synergistic effect in combination with phosphonoformate against human immunodeficiency virus type 1Q28342189
Pharmacokinetic estimations from microdialysis dataQ30870771
Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercocebus atys).Q35617653
Targets and strategies for the antiviral chemotherapy of AIDS.Q37925030
Development of antiviral drugs for the treatment of AIDS: strategies and prospectsQ38668999
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Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrierQ43805805
Early appearance of simian immunodeficiency virus (SIV) antigen and antibodies as variables in evaluating antiviral drugs in macaquesQ44739086
Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluidQ68350195
Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injectionQ68563314
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseasesQ68942769
Experimental infection of cynomolgus monkeys (Macaca fascicularis) with HIV-2Q93515302
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectzidovudineQ198504
P1104number of pages5
P304page(s)2418-2422
P577publication date1992-11-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePenetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action
P478volume36