Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels

scientific article

Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1022847276
P356DOI10.1186/ALZRT250
P932PMC publication ID4054957
P698PubMed publication ID24735568
P5875ResearchGate publication ID261740608

P50authorKaj BlennowQ28321550
P2093author name stringKeith A Wesnes
Hans Basun
Peter Annas
Chris Edgar
P2860cites workToward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ24595802
The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Q24599219
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Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48Q28297520
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separationQ30499942
A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairmentQ30585743
Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease.Q33359590
Pattern separation in the human hippocampal CA3 and dentate gyrus.Q33693396
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive ImpairmentQ34017939
Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment systemQ34118448
Adult hippocampal neurogenesis and its role in Alzheimer's diseaseQ34242416
Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adultsQ34441691
Pattern separation and pattern completion in Alzheimer's disease: evidence of rapid forgetting in amnestic mild cognitive impairmentQ35026669
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation.Q35618576
Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe.Q36013246
The dentate gyrus in Alzheimer's diseaseQ36926921
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult ratsQ37141222
Neurogenesis and Alzheimer's disease: at the crossroadsQ37584417
Disambiguating the similar: the dentate gyrus and pattern separation.Q37930070
Regulatory innovation and drug development for early-stage Alzheimer's diseaseQ43438827
Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's diseaseQ43558836
Visual object pattern separation deficits in nondemented older adults.Q46107208
Longitudinal stability of CSF biomarkers in Alzheimer's disease.Q53286684
Sting of Alzheimer's failures offset by upcoming prevention trials.Q53332313
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
cerebrospinal fluidQ54196
P304page(s)20
P577publication date2014-04-15
P1433published inAlzheimers Research & TherapyQ15716761
P1476titlePerformance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E ∈4 status and cerebrospinal fluid amyloid-β42 levels
P478volume6

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cites work (P2860)
Q56333867APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation
Q36877497Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss
Q39085129Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy
Q92615193Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease
Q48630247Deep Brain Stimulation of the Fornix: Engaging Therapeutic Circuits and Networks in Alzheimer Disease
Q93047538Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model
Q47885630Effects of aging and depression on mnemonic discrimination ability
Q36788646Hippocampal neurogenesis: Learning to remember
Q50080931Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss
Q47711122Integrating new findings and examining clinical applications of pattern separation
Q38643963Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease
Q90615602Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity
Q38482062Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers
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Q36253930Spatial pattern separation differences in older adult carriers and non-carriers for the apolipoprotein E epsilon 4 allele
Q38668333Tests of pattern separation and pattern completion in humans-A systematic review
Q34268936The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons

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