The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance

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The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...515380A
P356DOI10.1371/JOURNAL.PONE.0015380
P932PMC publication ID2976770
P698PubMed publication ID21085703
P5875ResearchGate publication ID47812992

P2093author name stringRichard M Badge
Rhona H Borts
Robert P Mason
Amit Dipak Amin
Alexandre B H Chaix
P2860cites workGenetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1Q73034734
Different domains of Sgs1 are required for mitotic and meiotic functionsQ73696436
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome geneQ73795297
Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicasesQ73844491
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseasesQ24317166
Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiaeQ24548535
Roles of RECQ helicases in recombination based DNA repair, genomic stability and agingQ24646853
The Bloom's syndrome gene product promotes branch migration of holliday junctionsQ24674127
Versatile and open software for comparing large genomesQ24807126
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein familyQ27930009
Supercomplex formation between Mlh1-Mlh3 and Sgs1-Top3 heterocomplexes in meiotic yeast cellsQ27933098
SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombinationQ27935480
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.Q27936079
Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregationQ27936086
Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complexQ27938674
RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombinationQ27939265
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complexQ27939442
Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregationQ27939683
Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Q27940287
New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiaeQ28131599
A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistanceQ28131606
Improved method for high efficiency transformation of intact yeast cellsQ28131608
Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiaeQ28131610
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyraseQ28170377
Mechanisms and functions of DNA mismatch repairQ28262719
Centromere-proximal crossovers are associated with precocious separation of sister chromatids during meiosis in Saccharomyces cerevisiaeQ28764746
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
The Bloom's syndrome helicase suppresses crossing over during homologous recombinationQ29547237
The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombinationQ29618523
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Major ecological transitions in wild sunflowers facilitated by hybridizationQ30004700
The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific fociQ30448876
Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.Q30827295
Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiaeQ32048153
RecQ helicases: guardian angels of the DNA replication forkQ33314341
The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome lossQ40020196
Synaptonemal complex and crossing-over: structural support or interference?Q40571789
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.Q40634607
Coming undone: how to untangle a chromosomeQ40666036
The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid.Q41064501
Specific pathways prevent duplication-mediated genome rearrangementsQ41927457
SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiaeQ42967143
The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1.Q43198272
The N-terminal region of Sgs1, which interacts with Top3, is required for complementation of MMS sensitivity and suppression of hyper-recombination in sgs1 disruptantsQ43720699
Homeologous recombination between AluSx-sequences as a cause of hemophiliaQ45878501
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiaeQ46062549
The Sgs1 Helicase Regulates Chromosome Synapsis and Meiotic Crossing OverQ47388021
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutantsQ50192890
Identification of double Holliday junctions as intermediates in meiotic recombination.Q54599520
Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous recombination in Saccharomyces cerevisiaeQ57451646
Human homologues of yeast helicaseQ59094515
Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation siteQ64389995
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repairQ33408756
Sources and evolution of human Alu repeated sequencesQ33585405
Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicaseQ33639225
The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctionsQ33707142
Mismatch repair proteins regulate heteroduplex formation during mitotic recombination in yeastQ33781506
Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins.Q33944291
Meiotic recombination frequencies are affected by nutritional states in SaccharomycescerevisiaeQ33952006
The subtelomeric Y' repeat family in Saccharomyces cerevisiae: an experimental system for repeated sequence evolution.Q33956252
Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiaeQ33964716
Sgs1 helicase activity is required for mitotic but apparently not for meiotic functionsQ33965180
Biochemical Mutants in the Smut Fungus Ustilago Maydis.Q33975198
Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiaeQ34569374
Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removalQ34570828
The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast.Q34606599
Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genesQ34608647
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiaeQ34608894
Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicasesQ34772977
Chromosome choreography: the meiotic balletQ35195590
Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1Q35318165
Early decision; meiotic crossover interference prior to stable strand exchange and synapsisQ35739105
Roles of RecA homologues Rad51 and Dmc1 during meiotic recombinationQ35910251
BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint moleculesQ36082370
Chromosome evolution in eukaryotes: a multi-kingdom perspectiveQ36293593
Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi.Q36574936
Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repairQ37072156
Interaction of genetic and environmental factors in Saccharomyces cerevisiae meiosis: the devil is in the details.Q37607234
Ntg2p, a Saccharomyces cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage, interacts with the DNA mismatch repair protein Mlh1p. Identification of a Mlh1p binding motif.Q38288690
Interaction between yeast sgs1 helicase and DNA topoisomerase III.Q38311228
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Q38408536
Mismatch repair and the fidelity of genetic recombinationQ38730984
Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.Q39084503
Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpointQ39528622
Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repairQ39844167
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)e15380
P577publication date2010-11-09
P1433published inPLOS OneQ564954
P1476titleThe roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance
P478volume5

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cites work (P2860)
Q35135863In vivo evolution of metabolic pathways by homeologous recombination in mitotic cells
Q35497336In vivo evolution of metabolic pathways: Assembling old parts to build novel and functional structures
Q38172111Investigations of homologous recombination pathways and their regulation
Q47377567Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae
Q59810709Spore-autonomous fluorescent protein expression identifies meiotic chromosome mis-segregation as the principal cause of hybrid sterility in yeast

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