The alphaMbeta2 integrin and its role in neutrophil function

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The alphaMbeta2 integrin and its role in neutrophil function is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1006408028
P356DOI10.1038/SJ.CR.7290015
P8608Fatcat IDrelease_uotaisi34jdaxalfowyy5jb6ya
P698PubMed publication ID10520599
P5875ResearchGate publication ID12779127

P2093author name stringLi Z
P2860cites workFibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathwayQ24322038
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrinQ24563636
The Integrin α1 A-domain Is a Ligand Binding Site for Collagens and LamininQ58058124
Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrinQ71144166
Mac-1 (CD11b/CD18) is the predominant beta 2 (CD18) integrin mediating human neutrophil migration through synovial and dermal fibroblast barriersQ71446692
Contribution of LFA-1 and Mac-1 to CD18-dependent neutrophil emigration in a neonatal rabbit modelQ71531219
Modulation of proinflammatory cytokine release from human polymorphonuclear leukocytes by gamma interferonQ72149283
Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18)Q72391924
Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liverQ72970973
Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrinQ73144378
Identification and Reconstruction of the Binding Site within αMβ2 for a Specific and High Affinity Ligand, NIFQ73485968
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)Q27730377
The von willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motifQ27744418
Crystal structure of the I domain from integrin alpha2beta1Q27746750
Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharideQ28646196
Adhesion receptors of the immune systemQ29616393
Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitroQ34575307
Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cellsQ34733788
Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motifQ34957225
Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesionQ35810373
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18)Q35868877
Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domainQ35899468
Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surfaceQ36058293
Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogenQ36219687
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18)Q36224191
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).Q36236005
A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbitsQ36286707
Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes.Q36346014
Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotesQ36355119
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.Q36383058
Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1Q36651682
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient miceQ37365253
Tissue destruction by neutrophilsQ38264463
Adhesion molecules and inflammatory injury.Q38308430
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylationQ38334824
A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformationQ38339624
Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding proteinQ38347420
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigrationQ40543299
Binding and internalization of microorganisms by integrin receptorsQ40742836
The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesionQ41116964
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cellsQ41554017
A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand bindingQ41565145
A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammationQ42425839
Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesionQ42943798
A discrete sequence in a platelet integrin is involved in ligand recognitionQ43578287
Echovirus 1 interaction with the human very late antigen-2 (integrin alpha2beta1) I domain. Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion siteQ44175708
CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus.Q45180644
Critical threonine and aspartic acid residues within the I domains of beta 2 integrins for interactions with intercellular adhesion molecule 1 (ICAM-1) and C3biQ46900379
Inhibition of neutrophil adhesion reduces myocardial infarct sizeQ47385667
Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis.Q52485676
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.Q54296088
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)171-178
P577publication date1999-09-01
P1433published inCell ResearchQ1524018
P1476titleThe alphaMbeta2 integrin and its role in neutrophil function
P478volume9

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cites work (P2860)
Q34685199Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence.
Q35800590Constitutive integrin activation on tumor cells contributes to progression of leptomeningeal metastases
Q37264848Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms
Q60958205More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking
Q33722676Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins
Q32144953Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expression
Q41180375Peritoneal wash contents used to predict mortality in a murine sepsis model
Q35779411Platelet-neutrophil interactions under thromboinflammatory conditions
Q91962722The Role of Stabilin-1 in Lymphocyte Trafficking and Macrophage Scavenging in the Liver Microenvironment
Q33882871The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
Q37080009Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling

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