Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation

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Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.85742
P932PMC publication ID5453705
P698PubMed publication ID28570267

P50authorRaymond J SteptoeQ59556035
Andrew WilkinsonQ63425858
Jeremy F BrooksQ88154493
Geoffrey R HillQ38327210
P2093author name stringXiao Liu
Simon Phipps
Philip M Hansbro
Jay C Horvat
Janet M Davies
Rajeev Rudraraju
Malcolm R Starkey
Rhiannon B Werder
Soi-Cheng Law
Jane Al-Kouba
P2860cites workAntigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejectionQ39933853
Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children.Q40476204
Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.Q40647086
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigensQ41170875
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
Immunogenic, but not steady-state, antigen presentation permits regulatory T-cells to control CD8+ T-cell effector differentiation by IL-2 modulation.Q41869061
Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacyQ42282964
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoQ43687301
Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitisQ43959432
Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector functionQ44234403
Allergy immunotherapy: reduced health care costs in adults and children with allergic rhinitisQ44800434
Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance.Q44905201
Induction of B-cell tolerance by retroviral gene therapyQ45259617
Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion.Q45862484
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantationQ46140762
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus productionQ47732346
T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthmaQ48019510
Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses.Q51057483
Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.Q53573163
Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis-based comparison.Q55056712
Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elementsQ57228054
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responsesQ57667259
Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral toleranceQ58882235
Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapyQ60473182
Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthmaQ62555671
Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cellsQ81333474
Steady-state dendritic cells continuously inactivate T cells that escape thymic negative selectionQ84185759
Helios defines T cells being driven to tolerance in the periphery and thymusQ87697717
Molecular mechanisms for adaptive tolerance and other T cell anergy modelsQ24671646
The cell biology of asthmaQ27009449
Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveysQ29615415
T cell exhaustionQ29620463
Towards evidence-based medicine in specific grass pollen immunotherapyQ33520325
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.Q33750748
Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT studyQ34005065
Tolerization of a type I allergic immune response through transplantation of genetically modified hematopoietic stem cellsQ34361879
Cytokine/anti-cytokine therapy - novel treatments for asthma?Q34903133
Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetesQ34984972
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergyQ35196374
High IFN-γ and low SLPI mark severe asthma in mice and humansQ36040504
Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigenQ36340820
Persistent molecular microchimerism induces long-term tolerance towards a clinically relevant respiratory allergenQ36651903
Cell Therapy for Prophylactic Tolerance in Immunoglobulin E-mediated AllergyQ37008459
Understanding the mechanisms of viral induced asthma: new therapeutic directionsQ37072079
Harnessing regulatory T cells to suppress asthma: from potential to therapyQ37680540
Allergen immunotherapy and health care cost benefits for children with allergic rhinitis: a large-scale, retrospective, matched cohort studyQ37689682
Allergy for a lifetime?Q37698892
Potential therapeutic targets for steroid-resistant asthmaQ37735868
Allergen-specific immunotherapy for respiratory allergies: from meta-analysis to registration and beyond.Q37802050
Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthmaQ37841594
Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway diseaseQ37847719
Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.Q37859521
Emerging roles of pulmonary macrophages in driving the development of severe asthmaQ37980316
Virus infection and allergy in the development of asthma: what is the connection?Q37987301
Induction of antigen-specific tolerance through hematopoietic stem cell-mediated gene therapy: the future for therapy of autoimmune disease?Q38050613
Th2 cytokine antagonists: potential treatments for severe asthmaQ38057796
Novel immunotherapy vaccine developmentQ38258988
Current developments for improving efficacy of allergy vaccines.Q38503330
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infectionQ38812394
P433issue11
P577publication date2017-06-02
P1433published inJCI insightQ27727187
P1476titleAllergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation
P478volume2