Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway

scientific article

Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS15058153
P932PMC publication ID4057725
P698PubMed publication ID24821539
P5875ResearchGate publication ID262266840

P2093author name stringLin Zhang
Zhifeng Zhang
Junjie Wang
Dongmei Hu
Junsong Wang
Zhichen Pu
P2860cites workEndothelium-dependent contraction and direct relaxation induced by baicalein in rat mesenteric artery.Q50517624
Gene expression of cyclin-dependent kinase inhibitors and effect of heparin on their expression in mice with hypoxia-induced pulmonary hypertension.Q53620925
Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation.Q55033846
Hypoxia-Inducible Factor-1 (HIF-1)Q61645733
Primary pulmonary hypertensionQ71957743
Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxiaQ74014913
Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in miceQ81287302
p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in miceQ83447580
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alphaQ28508120
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cellsQ32178195
Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient miceQ33908586
Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in ratsQ34499303
Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanismsQ34569861
mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxiaQ35003274
The subtle side to hypoxia inducible factor (HIFalpha) regulationQ35072135
Mechanisms controlling vascular tone in pulmonary arterial hypertension: implications for vasodilator therapyQ36674960
Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells.Q36780880
The effects of hypoxia on the cells of the pulmonary vasculature.Q36897809
Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT.Q40048075
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells.Q40427466
Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.Q40475869
G1 control in mammalian cells.Q40608634
Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrestQ40762945
Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cellsQ41491090
Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasiaQ42957166
Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1.Q43097731
Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric arteryQ43156142
p27(Kip1) is important in modulating pulmonary artery smooth muscle cell proliferationQ43802288
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytesQ44371439
p42/44 Mitogen-activated protein kinase regulated by p53 and nitric oxide in human pulmonary arterial smooth muscle cellsQ44796905
Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.Q45203261
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
baicalinQ2879368
P304page(s)8153-8168
P577publication date2014-05-09
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleBaicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway
P478volume15

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cites work (P2860)
Q54247627Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation.
Q38355368Adaptive capacity of the right ventricle: why does it fail?
Q34158444BMP4 protects rat pulmonary arterial smooth muscle cells from apoptosis by PI3K/AKT/Smad1/5/8 signaling
Q42039588Baicalin attenuates monocrotaline-induced pulmonary hypertension through bone morphogenetic protein signaling pathway
Q64062342Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo
Q42675830Effects of FHL1 and P21 on hypoxia-induced pulmonary vascular remodeling in neonatal rats
Q61796849Flavones hydroxylated at 5, 7, 3' and 4' ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity
Q51531544Involvement of CapG in proliferation and apoptosis of pulmonary arterial smooth muscle cells and in hypoxia-induced pulmonary hypertension rat model.
Q38622836Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.
Q92906572Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice
Q92724115Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases
Q60950901Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach
Q35700589The COP9 signalosome and vascular function: intriguing possibilities?

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