| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Martin Giera | Q42423693 |
| Wilfried Niessen | Q42697108 | ||
| P2093 | author name string | Jeroen Kool | |
| Hubertus Irth | |||
| P2860 | cites work | Free flow electrophoresis device for continuous on-line separation in analytical systems. An application in biochemical detection | Q30653071 |
| High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products | Q30854673 | ||
| Continuous-flow, on-line monitoring of biospecific interactions using electrospray mass spectrometry | Q74457738 | ||
| Gradient reversed-phase liquid chromatography coupled on-line to receptor-affinity detection based on the urokinase receptor | Q77477485 | ||
| Selective detection and identification of phosphorylated proteins by simultaneous ligand-exchange fluorescence detection and mass spectrometry | Q79837948 | ||
| MS-binding assays: kinetic, saturation, and competitive experiments based on quantitation of bound marker as exemplified by the GABA transporter mGAT1 | Q80067141 | ||
| Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6 | Q81160520 | ||
| Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes | Q81369364 | ||
| Real-time mass spectrometry in enzymology | Q81416469 | ||
| Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen | Q83837636 | ||
| Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine | Q84216879 | ||
| Screening and isolation of a natural dopamine D1 receptor antagonist using cell-based assays | Q30956574 | ||
| Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry | Q31036682 | ||
| High throughput screening via mass spectrometry: a case study using acetylcholinesterase | Q31110858 | ||
| High resolution screening of plant natural product extracts for estrogen receptor alpha and beta binding activity using an online HPLC-MS biochemical detection system | Q32027588 | ||
| High-throughput bioassay-guided fractionation: a technique for rapidly assigning observed activity to individual components of combinatorial libraries, screened in HTS bioassays | Q33185142 | ||
| Characterization and performance of MALDI on a triple quadrupole mass spectrometer for analysis and quantification of small molecules | Q33222578 | ||
| Functional assays for screening GPCR targets | Q33226232 | ||
| Design considerations for high speed quantitative mass spectrometry with MALDI ionization | Q33245600 | ||
| Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures. | Q33279739 | ||
| New aspects of natural products in drug discovery | Q33282072 | ||
| High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase | Q33283646 | ||
| High-throughput screening by mass spectrometry: comparison with the scintillation proximity assay with a focused-file screen of AKT1/PKB alpha. | Q33283651 | ||
| LC-MALDI MS and MS/MS--an efficient tool in proteome analysis. | Q33303441 | ||
| How to confirm identified toxicants in effect-directed analysis | Q33316763 | ||
| Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors | Q33358494 | ||
| Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry | Q33369323 | ||
| Development of an inhibitor screening platform via mass spectrometry | Q33386658 | ||
| Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening | Q33438454 | ||
| Mass spectrometry in high-throughput screening: a case study on acetyl-coenzyme a carboxylase using RapidFire--mass spectrometry (RF-MS). | Q33468595 | ||
| High-throughput screening of the cyclic AMP-dependent protein kinase (PKA) using the caliper microfluidic platform | Q33473943 | ||
| MS binding assays-with MALDI toward high throughput | Q33475751 | ||
| Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications | Q33498091 | ||
| Screening for antibacterial inhibitors of the UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) using a high-throughput mass spectrometry assay | Q33519474 | ||
| Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR. | Q33530779 | ||
| Multiplex enzyme assays and inhibitor screening by mass spectrometry | Q33540644 | ||
| Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification | Q33592479 | ||
| Recent developments in protein-ligand affinity mass spectrometry. | Q33740704 | ||
| The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'. | Q33907028 | ||
| High throughput assay technologies for ion channel drug discovery. | Q36020500 | ||
| Analytical methods in environmental effects-directed investigations of effluents | Q36118846 | ||
| Monitoring enzymatic conversions by mass spectrometry: a critical review | Q36188802 | ||
| Effect-directed analysis of key toxicants in European river basins a review. | Q36757506 | ||
| A review of high throughput technology for the screening of natural products | Q36907725 | ||
| Analytical strategies for phosphoproteomics | Q37398801 | ||
| High throughput screening methodologies classified for major drug target classes according to target signaling pathways | Q37739503 | ||
| Effect-related monitoring: estrogen-like substances in groundwater | Q39208644 | ||
| HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts | Q40523437 | ||
| Applying hollow fibres for separating free and bound label in continuous-flow immunochemical detection | Q40917161 | ||
| Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS. | Q42423587 | ||
| Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb | Q42995860 | ||
| Structural elucidation of biologically active neomycin N-octyl derivatives in a regioisomeric mixture by means of liquid chromatography/ion trap time-of-flight mass spectrometry | Q43089270 | ||
| Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization | Q43105885 | ||
| Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment | Q43172933 | ||
| Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis | Q43186853 | ||
| Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis | Q43260602 | ||
| Bioactivities of Plectranthus ecklonii constituents. | Q43260966 | ||
| A generic assay for phosphate-consuming or -releasing enzymes coupled on-line to liquid chromatography for lead finding in natural products | Q44403091 | ||
| Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay | Q44469750 | ||
| Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization | Q44624302 | ||
| On-line continuous-flow, multi-protein biochemical assays for the characterization of bioaffinity compounds using electrospray quadrupole time-of-flight mass spectrometry. | Q44626018 | ||
| Liquid chromatography coupled on-line to flow cytometry for postcolumn homogeneous biochemical detection | Q44664888 | ||
| High-throughput biochemical kinase selectivity assays: panel development and screening applications. | Q45901707 | ||
| Development of a liquid chromatography-based screening methodology for proteolytic enzyme activity | Q46059787 | ||
| Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. | Q46205857 | ||
| Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry | Q46227677 | ||
| Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates | Q46260757 | ||
| Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening | Q46308702 | ||
| Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s | Q46348074 | ||
| Effect-directed analysis by high-performance liquid chromatography with gas-segmented enzyme inhibition | Q46730427 | ||
| High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection | Q46849009 | ||
| Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3. | Q46934310 | ||
| High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts | Q46975306 | ||
| Comparison of on-chip and off-chip microfluidic kinase assay formats. | Q47424569 | ||
| On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry | Q49206424 | ||
| Ligand-exchange detection of phosphorylated peptides using liquid chromatography electrospray mass spectrometry. | Q50491716 | ||
| On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators. | Q51175554 | ||
| Assay development and screening of a serine/threonine kinase in an on-chip mode using caliper nanofluidics technology. | Q51585527 | ||
| A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry. | Q51590422 | ||
| Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. I. Detection systems based on labelled ligands. | Q52252037 | ||
| Microfractionation revisited: a 1536 well high resolution screening assay. | Q54740520 | ||
| High-performance liquid chromatographic postcolumn reaction detection based on a competitive binding system | Q68377390 | ||
| Reversed-phase liquid chromatography coupled on-line to receptor affinity detection based on the human estrogen receptor | Q71126455 | ||
| Sensitive and selective liquid chromatographic postcolumn reaction detection system for biotin and biocytin using a homogeneous fluorophore-linked assay | Q72691480 | ||
| Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. II. Detection systems based on labelled affinity proteins | Q74101659 | ||
| Bioassay-directed chemical analysis of River Elbe surface water including large volume extractions and high performance fractionation | Q74342062 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | biomedical investigative technique | Q66648976 |
| P304 | page(s) | 2655-2668 | |
| P577 | publication date | 2010-11-24 | |
| P1433 | published in | Analytical and Bioanalytical Chemistry | Q2845280 |
| P1476 | title | Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures | |
| P478 | volume | 399 |
| Q42363689 | A multiple biomarker assay for quality assessment of botanical drugs using a versatile microfluidic chip |
| Q36239113 | A unifying review of bioassay-guided fractionation, effect-directed analysis and related techniques. |
| Q58859735 | Analytical techniques for discovery of bioactive compounds from marine fungi |
| Q40136029 | At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor |
| Q92366075 | Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation |
| Q34608038 | Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays |
| Q28975879 | Current approaches and challenges for the metabolite profiling of complex natural extracts |
| Q87041995 | Determination of α-glucosidase inhibitors from Scutellaria baicalensis using liquid chromatography with quadrupole time of flight tandem mass spectrometry coupled with centrifugal ultrafiltration |
| Q41887470 | Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures. |
| Q35894686 | Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms |
| Q38001424 | Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives |
| Q37902554 | Functional proteomics: application of mass spectrometry to the study of enzymology in complex mixtures |
| Q51483748 | Microfluidic Chip-Based Online Screening Coupled to Mass Spectrometry: Identification of Inhibitors of Thrombin and Factor Xa. |
| Q39214495 | Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail |
| Q35857213 | On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors. |
| Q27014989 | Pharmaceutical and biomedical applications of affinity chromatography: recent trends and developments |
| Q35939772 | Statistical Correlations between HPLC Activity-Based Profiling Results and NMR/MS Microfraction Data to Deconvolute Bioactive Compounds in Mixtures |
| Q34748950 | Tandem mass spectrometry study of p38α kinase inhibitors and related substances. |
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