Hepatocyte nuclear factor 4α (HNF4α) in coordination with retinoic acid receptors increases all-trans-retinoic acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes

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Hepatocyte nuclear factor 4α (HNF4α) in coordination with retinoic acid receptors increases all-trans-retinoic acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.24839
P932PMC publication ID5456459
P698PubMed publication ID24819304

P2093author name stringA Catharine Ross
Reza Zolfaghari
P2860cites workLiver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.Q36629289
RAR and RXR modulation in cancer and metabolic diseaseQ36956230
Cytochrome P450s in the regulation of cellular retinoic acid metabolismQ37212128
Lipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivoQ37349080
The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesisQ37789002
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Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expressionQ39528701
An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) geneQ39814860
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.Q40442109
Regulation of human apolipoprotein m gene expression by orphan and ligand-dependent nuclear receptors.Q42049578
Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivoQ44020686
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.Q46983610
Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and ratsQ73054272
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Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genesQ24308340
Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibilityQ24535602
Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and ratsQ24798478
Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolismQ28138026
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisQ28591211
A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promotersQ28594426
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigenQ29617963
Retinoic acid actions through mammalian nuclear receptorsQ30408649
Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liverQ34047395
HNF4α—role in drug metabolism and potential drug target?Q34311568
Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liverQ34357497
Multiple cytochrome P-450 genes are concomitantly regulated by vitamin A under steady-state conditions and by retinoic acid during hepatic first-pass metabolismQ34518046
Retinoid receptors and their coregulatorsQ34762706
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Nuclear retinoid receptors and the transcription of retinoid-target genesQ35690779
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptorsQ36061886
P433issue10
P921main subjecttretinoinQ29417
P304page(s)1740-1751
P577publication date2014-10-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleHepatocyte nuclear factor 4α (HNF4α) in coordination with retinoic acid receptors increases all-trans-retinoic acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes
P478volume115

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cites work (P2860)
Q64005257Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome
Q58792788Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

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